Ehtewish H, Mesleh A, Ponirakis G, De la Fuente A, Parray A, Bensmail I, Abdesselem HB, Ramadan M, Khan S, Chandran M, Ayadathil R , Elsotouhy A, Own A, Al Hamad H, Abdelalim EM , Decock J , Alajez NM , Albagha O , Thornalley PJ , Arredouani I , Malik R, and El-Agnaf OMA. Blood-Based Proteomic Profiling Identifies Potential Biomarker Candidates and Pathogenic Pathways in Dementia. Int. J. Mol. Sci. 2023, 24, 8117.

The Gatan Precision Ion Polishing System II is used to mill dimpled samples to electron transparency as a cheaper alternative to FIB milling. It is also used to clean unwanted redeposition off of TEM lamellae made by FIB.

Denton Vacuum Explorer™ evaporator system has both thermal and electron beam evaporation sources. There is a single mass flow controller (MFC) that is currently used for reactive deposition of oxides. The chamber can be heated up to 150 °C. In addition, the system can accommodate substrates up to 6” in diameter; hence, it keeps the space of accommodating various substrate sizes as per application needs.

The MBE can handle up to 4” dia. substrates. One chamber has oxygen plasma as well as e-beam evaporation capability and is used for reactive deposition of oxides. The second chamber is dedicated for semiconductor compounds. Veeco's GEN20™ MBE system is an ultra-flexible tool with a design configurable for III-V and emerging materials, including applications that require the integration of e-beam technology. The system incorporates production design technology that allows for an optional cluster tool wafer transfer system for an ideal lab-tofab migration.

Yahya Abdi I, Bartl M, Dakna M, Abdesselem H, Majbour N, Trenkwalder C, El Agnaf O, Mollenhauer B. Cross-sectional proteomic expression in Parkinson’s disease-related proteins in drug-naïve patients vs healthy controls with longitudinal clinical follow-up. Neurobiology of Disease. MS NBD-22-775R. Accepted Jan 2023.

El-Agnaf O, Bensmail I, Al-Nesf M. A.Y, Flynn J, Taylor M, Majbour N, Abdi I.Y, Vaikath N, Farooq, Vemulapalli PB, Schmidt F, Ouararhni K, Al-Siddiqi H, Arredouani A, Wijten P, Al-Maadheed M, Mohamed-Ali V, Decock J, Abdesselem HB. Uncovering a neurological protein signature for severe COVID-19. Neurobiology of Disease, 2023.

The Scanning Auger Microprobe (SAM) technique is a highly versatile surface analysis technique that allows for precise and accurate mapping of the elemental composition of materials at the micrometer scale. This technique is based on the Auger electron spectroscopy (AES) principle, which is a wellestablished analytical technique used to study the surface chemistry of materials. The SAM technique is a variation of AES, which involves scanning a small electron beam over the sample surface to generate a two-dimensional elemental map of the surface.

Areej Mesleh, Hanan Ehtewish, Katie Lennard, Houari Abdesselem, Fouad Al- Shaban, Julie Decock, Nehad M. Alajez, Abdelilah Arredouani, Mohamed M. Emara, Omar Albagha, Lawrence w. Stanton, Sara A. Abdulla, Jonathan M. Blackburn, Omar M.A. El-Agnaf. High-throughput Autoantibody Screening Identifies Differentially Abundant Autoantibodies in Autism Spectrum Disorder. Frontiers in Molecular Neuroscience, section Brain Disease Mechanisms. Accepted, Sep 2023.

Schmidt F, Abdesselem HB, Suhre K, Sohail MU, Al-Nesf M, Bensmail I, Mashod F, Sarwath H, Bernhardt J, Tan T.M, Morris P.E, Schenck E.J, Price D, Vaikath N.N, Mohamed-Ali V, Al-Maadheed M, Arredouani A, Decock J, Blackburn J.M, Choi A.M.K, and El-Agnaf O.M. Auto-Immunoproteomics Analysis of COVID-19 ICU Patients Revealed Increased Levels of Autoantibodies Related to Male Reproductive System. Front Physiol. 2023 Jul 14;14:1203723. doi: 10.3389/fphys.2023.1203723. eCollection 2023. PMID: 37520825.

Differential scanning calorimetry (DSC) is a widely used technique in materials science to investigate the thermal behavior of materials. The technique involves measuring the difference in heat flow between a sample and a reference material as the temperature is changed over a certain range. The sample is heated or cooled at a controlled rate, and the heat flow into or out of the sample is monitored using a set of thermocouples.