Dr. Yongsoo Park | Hamad Bin Khalifa University
Hamad Bin Khalifa University

FACULTY BIOGRAPHIES

Dr. Yongsoo Park

Dr. Yongsoo Park (PhD)


Scientist
Neurological Disorders Research Center
Qatar Biomedical Research Institute QBRI

Joint Assistant Professor
College of Health and Life Sciences

  • Phone50 156 360
  • Office locationB2-1428

Biography

Dr. Yongsoo Park joined the Qatar Biomedical Research Institute (QBRI), in September 2019. 

For his doctoral work he investigated exocytosis and plasticity of vesicle fusion at the POSTECH (Pohang University of Science and Technology), South Korea. After completing his PhD in 2009, he worked as a postdoctoral researcher at the Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany, where he was trained by mentor Professor Reinhard Jahn, a world-renowned scientist known for his pioneering research into fusion and neurotransmitter release. 

In 2019 Dr. Park moved to HBKU as a scientist at QBRI and is also affiliated with HBKU’s College of Health and Life Sciences (CHLS) as an assistant professor.

Dr. Park has received many awards and fellowships from international organizations including the Science Academy's Young Scientist Awards Program (BAGEP), the Marie Curie Actions of the European Union's 7th Framework Programme, and the Alexander von Humboldt Foundation. He has obtained multiple research grants including the highly prestigious European Molecular Biology Organization (EMBO) Installation Grant. 

 


Research Interests

  • Exosome Biomarkers for Neurological Disorders Including Autism Spectrum Disorder
  • Use of Neuronal Differentiation of Human Induced Pluripotent Stem Cells (hiPSC) as a Disease Model of ASD, Alzheimer's Disease, and Parkinson’s Disease
  • Molecular Mechanisms of Neuronal Degeneration in Parkinson’s Disease and microRNA Exocytosis in Health and Disease

Experience

Scientist

Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Education City, Doha, Qatar

August 2019 – Present
  • Assistant Professor

    College of Health & Life Sciences, Hamad Bin Khalifa University (HBKU), Education City, Doha, Qatar.

    August 2020 – Present
  • Visiting Professor

    Department of Molecular Biology and Genetics, Koç University, Istanbul, Turkey

    September 2019 – Present
  • Assistant Professor

    Department of Molecular Biology and Genetics, Koç University, Istanbul, Turkey

    September 2017 – August 2019
  • Assistant Professor

    Izmir International Biomedicine and Genome Institute, Turkey

    December 2015 – August 2017
  • Visiting Professor

    POSTECH (Pohang University of Science and Technology), Division of Integrative Biosciences and Biotechnology, South Korea

    August 2016
  • Postdoctoral Fellow

    Max-Planck-Institute for Biophysical Chemistry, Department of Neurobiology, Goettingen, Germany (mentor: Prof. Dr. Reinhard Jahn)

    June 2009 – December 2015

Education

PhD in Molecular Neurobiology

POSTECH (Pohang University of Science and Technology)

2002 - 2009
  • BS in Life Science

    Handong Global University

    1996 - 2001

Selected Publications

  • Park Y# and Ryu JK#. Models of synaptotagmin-1 to trigger Ca2+-dependent vesicle fusion

    FEBS Lett. 2018 Nov;592(21):3480-3492.

    2018
  • Park Y#, MicroRNA exocytosis by vesicle fusion in neuroendocrine cells

    Front Endocrinol. 2017 Dec 22;8:355.

    2017
  • Gümürdü A, Yildiz R, Eren E, Karakülah G, Ünver T, GENÇ Ş, and Park Y#

    MicroRNA exocytosis by large dense-core vesicle fusion. Sci Rep. 2017 Mar 30;7:45661.

    2017
  • Park Y, Seo JB, Fraind A, Pérez-Lara A, Yavuz H, Han K, Jung SR, Kattan I, Walla PJ, Choi MY, Cafiso DS, Koh DS, Jahn R.

    Synaptotagmin-1 binds to PIP2-containing membrane but not to SNAREs at physiological ionic strength. Nature Struct Mol Biol. 2015 Oct;22(10):815-823.

    2015
  • Park Y, Vennekate W, Yavuz H, Preobraschenski J, Hernandez JM, Riedel D, Walla PJ, Jahn R

    α-SNAP interferes with the zippering of the SNARE membrane fusion machinery. J Biol Chem. 2014 Jun 6;289(23):16326-16335.

    2014
  • Park Y, Hernandez J. M, van den Bogaart G, Ahmed S, Holt M, Riedel D, and Jahn R

    Controlling synaptotagmin activity by electrostatic screening. Nature Struct Mol Biol. 2012 Oct;19(10):991-997.

    2012
  • Park Y and Kim KT.

    Dominant role of lipid rafts L-type calcium channel in activity-dependent potentiation of large dense-core vesicle exocytosis. J Neurochem. 2009 Jul;110(2):520-529.

    2009
  • Park Y and Kim KT.

    Short-term plasticity of small synaptic vesicle (SSV) and large dense-core vesicle (LDCV) exocytosis. Cell Signal. 2009 Oct;21(10):1465-70.

    2009
  • Park YS, Choi YH, Park CH, Kim KT.

    Non-genomic glucocorticoid effects on activity-dependent potentiation of catecholamine release in chromaffin cells. Endocrinology. 2008 Oct;149(10):4921-7.

    2008
  • Park YS, Hur EM, Choi BH, Kwak E, Jun DJ, Park SJ, Kim KT.

    Involvement of protein kinase C-epsilon in activity-dependent potentiation of large dense-core vesicle exocytosis in chromaffin cells. J Neurosci. 2006 Aug 30;26(35): 8999-9005.

    2006
  • (Cover article) Park YS, Jun DJ, Hur EM, Lee SK, Suh BS, Kim KT.

    Activity-dependent potentiation of large dense-core vesicle release modulated by mitogen-activated protein kinase(MAPK)/ERK signaling. Endocrinology. 2006 Mar;147(3):1349-56.

    2006
  • Birinci Y, Preobraschenski J, Ganzella M, Jahn R#, Park Y#.

    Isolation of large dense-core vesicles from bovine adrenal medulla for functional studies. Sci Rep. 2020 May 5;10(1):7540.

    2020
  • Park Y# and Ryu JK#.

    Models of synaptotagmin-1 to trigger Ca2+-dependent vesicle fusion. FEBS Lett. 2018 Nov;592(21):3480-3492.

    2018
  • Park Y#

    MicroRNA exocytosis by vesicle fusion in neuroendocrine cells. Front Endocrinol. 2017 Dec 22;8:355.

    2017
  • Gümürdü A, Yildiz R, Eren E, Karakülah G, Ünver T, GENÇ Ş, and Park Y#.

    MicroRNA exocytosis by large dense-core vesicle fusion. Sci Rep. 2017 Mar 30;7:45661.

    2017
  • Park Y, Seo JB, Fraind A, Pérez-Lara A, Yavuz H, Han K, Jung SR, Kattan I, Walla PJ, Choi MY, Cafiso DS, Koh DS, Jahn R.

    Synaptotagmin-1 binds to PIP2-containing membrane but not to SNAREs at physiological ionic strength. Nature Struct Mol Biol. 2015 Oct;22(10):815-823.

    2015
  • Park Y, Vennekate W, Yavuz H, Preobraschenski J, Hernandez JM, Riedel D, Walla PJ, Jahn R.

    α-SNAP interferes with the zippering of the SNARE membrane fusion machinery. J Biol Chem. 2014 Jun 6;289(23):16326-16335.

    2014
  • Park Y, Hernandez J. M, van den Bogaart G, Ahmed S, Holt M, Riedel D, and Jahn R.

    Controlling synaptotagmin activity by electrostatic screening. Nature Struct Mol Biol. 2012 Oct;19(10):991-997.

    2012
  • Park Y and Kim KT.

    Dominant role of lipid rafts L-type calcium channel in activity-dependent potentiation of large dense-core vesicle exocytosis. J Neurochem. 2009 Jul;110(2):520-529.

    2009
  • Park Y and Kim KT.

    Short-term plasticity of small synaptic vesicle (SSV) and large dense-core vesicle (LDCV) exocytosis. Cell Signal. 2009 Oct;21(10):1465-70.

    2009
  • Park YS, Choi YH, Park CH, Kim KT.

    Non-genomic glucocorticoid effects on activity-dependent potentiation of catecholamine release in chromaffin cells. Endocrinology. 2008 Oct;149(10):4921-7.

    2008
  • Park YS, Hur EM, Choi BH, Kwak E, Jun DJ, Park SJ, Kim KT.

    Involvement of protein kinase C-epsilon in activity-dependent potentiation of large dense-core vesicle exocytosis in chromaffin cells. J Neurosci. 2006 Aug 30;26(35): 8999-9005.

    2006
  • Park YS, Jun DJ, Hur EM, Lee SK, Suh BS, Kim KT.

    Activity-dependent potentiation of large dense-core vesicle release modulated by mitogen-activated protein kinase(MAPK)/ERK signaling. Endocrinology. 2006 Mar;147(3):1349-56. (Cover article)

    2006