Neyla Al Akl

Senior Research Associate

Neyla Al Akl

Senior Research Associate

Entity

Qatar Biomedical Research Institute

Division

Diabetes Research Center

Biography

Mrs. Neyla Al Akl received her Bachelor’s degree in Medical Laboratory Technology from the Balamand University, Lebanon and pursued her Master’s in Immunology and Microbiology from the American University of Beirut, Lebanon. She worked as an assistant embryologist at EVE Fertility Center in Beirut and after obtaining her MS degree she joined the department of Experimental pathology, Immunology and Microbiology at the American University of Beirut as a Research Assistant. During her 7 years of laboratory research work she was involved in several projects related to the effect of bovine cartilage, antibiotics and Coley’s mixed bacterial toxin on tumor growth, in addition to defining the mechanism of action of certain vaccine adjuvants.

Mrs Neyla joined QBRI in 2018 and is part of Dr. Arredouani's team. She provides technical and administrative support to all members of the team and is also involved in a research project that focuses on the association between the salivary alpha- amylase and metabolic disorders in the Qatari population.

 

Aisha AlMulla

Master's Student

Aisha AlMulla

Master's Student

Entity

Qatar Biomedical Research Institute

Division

Diabetes Research Center

Biography

Ms. Aisha AlMulla is currently pursuing her Master's in Biological and Biomedical Sciences at Hamad Bin Khalifa University (HBKU), and is working under the supervision of Dr. Essam Abdelalim of QBRI. She obtained her Bachelor’s degree in Biological Sciences (Cancer Biology) from the University of Westminster, London in 2017. She worked on exploring the role of Epithelial-to-Mesenchymal Transition markers in HER2+ breast cancer cells, mainly focusing on the expression levels of the mesenchymal marker SNAIL involved in metastasis of primary cancer cells to secondary organs.

She gained brief experience from working on differentiation and maintenance of iPSCs in Dr. Essam Abdelalim’s laboratory in 2014. Keeping in view the promising applications of stem cells in disease treatment, she is currently working on the generation and differentiation of pluripotent stem cells to hepatocytes in the same lab, as a part of a bigger project that explores the pathogenesis and underlying molecular mechanisms of insulin resistance and diabetes.

 

Eman W. Abdelsalam

PhD Student

Eman W. Abdelsalam

PhD Student

Entity

Qatar Biomedical Research Institute

Division

Diabetes Research Center

Biography

Ms. Eman W. Abdelsalam is a PhD student at Hamad Bin Khalifa University (HBKU) in the Genomics and Precision Medicine (GPM) program, since August, 2017. Her thesis focuses on studying inherited insulin resistance in the offspring of parents with type 2 diabetes, using human induced pluripotent stem cells (hiPSCs) - under the supervision of Dr. Essam Abdelalim. She obtained her Master 's and Bachelor's degrees in Microbiology from Benha University in Egypt. In 2014, Eman joined Qatar University as a Research Assistant at the College of Arts and Science (CAS), where she was involved in projects studying the microbial community analyses and impact network analysis toward integrated disease management and other ecological concerns.

Ms. Eman W. Abdelsalam was also involved in a project focused on the isolation of natural products from medicinal plants used in Qatari traditional medicine and the determination of their antimicrobial, antioxidant and anticancer properties. In 2017, she joined Biomedical Research Center (BRC) at Qatar University as a research assistant, where she participated in different research projects in collaboration with Hamad medical corporation (HMC), Ministry of Environment, College of health Science and others. Her interest was to investigate the Epidemiologic and Genotypic characteristics of ESBL and carbapenems among clinical isolates from children presented with urinary tract infection (UTI) in primary health care in Qatar. Mrs. Abdelsalam received the Best Faculty & Postdoc Poster Award in medical, biomedical and health science in 2018.

 

Dr. Borbala Mifsud

Associate Professor

Phone

44547244

Office location

B144, 1st floor, LAS building

Dr. Borbala Mifsud

Associate Professor

Educational Qualifications

PhD

MSc

Entity

College of Health and Life Sciences

Biography

Dr. Mifsud graduated in biology from Eotvos Lorand University in Budapest in 2006 and obtained her PhD from the Institute of Molecular Pathology in Vienna in 2010. Her work with Thomas Jenuwein involved the epigenetic characterisation of a histone methylation deficient mouse model. After her molecular biology training, she started bioinformatics in the laboratory of Professor Nicholas Luscombe at EMBL European Bioinformatics Institute (EBI) in Cambridge, and subsequently moved to UCL and the Crick Institute in London. In her postdoctoral work she focussed on developing methods for the analysis of Hi-C type data and finding new biological insights into transcriptional regulation, by applying these methods to Hi-C and capture Hi-C data sets. Dr. Mifsud joined the William Harvey Research Insitute in QMUL as an MRC eMedLab Career Development Fellow and Lecturer in 2015, where she used chromatin interaction data to understand the function of regulatory GWAS mutations. Dr. Mifsud has been an Assistant Professor at HBKU since July 2018.

 

PhD

University of Vienna, Austria

2010

MSc

Eotvos Lorand University, Hungary

2006

  • Using chromatin structure information for understanding the effect of GWAS loci
  • Uncovering chromatin interactions that change during development
  • Identifying the important regulatory interactions in diseases such as leukaemia

MRC Career Development Fellow - Lecturer;

William Harvey Research Institute; Queen Mary University London, UK

2015 - 2018

Postdoctoral Research Fellow

University College London and the Francis Crick Instiute, London, UK

2012 - 2015

Postdoctoral Research Fellow

EBML European Bioinformatics Institute; Cambridge, UK

2010 - 2012

PhD Student

Institute of Molecular Pathology, Vienna, Austria

2006 - 2010

Diploma Student

National Centre for Epidemiology, Budapest, Hungary

2004 - 2006

Student researcher

Department of Plant Taxonomy, Eotvos Lorand University, Budapest, Hungary

2003 - 2004

Nature Genetics; 2018 Sep; doi: 10.1038/s41588-018-0205-x Evangelou E.*, Warren H.R.*, Mosen-Ansorena D.*, Mifsud B.*, Pazoki R.*, He G.*, Ntritsos G.*, Dimou N.* et al

Nature Communications; 2018 May 16;9(1):1947. Ramírez J., Duijvenboden S.V. Ntalla I., Mifsud B., Warren H.R., Tzanis E., Orini M., Tinker A., Lambiase P.D., Munroe P.B.

PLoS One; 2017 Apr 5;12(4):e0174744 Mifsud B.*, Martincorena I.*, Darbo E., Sugar R., Schoenfelder S., Fraser P., Luscombe N.M.

Nature Genetics; 2017 Mar;49(3):403-415 Warren H.R.*, Evangelou E.*, Cabrera C.P.*, Gao H.*, Ren M*., Mifsud B.*, et al

Nature Genetics; 2015 Oct;47(10):1179-86 Schoenfelder S.*, Sugar R.*, Dimond A.*, Javierre B-M.*, Armstrong H.*, Mifsud B., Dimitrova E., Tavares-Cadete F., Furlan-Magaril M., Jurkowski W., Segonds-Pichon A., Wingett S., Tabbada K., Andrews S., Herman B., LeProust E., Osborne C.S., Koseki H., Fraser P., Luscombe N.M., Elderkin S.

Nature Genetics; 2015 Jun;47(6):598-606 Mifsud B.*, Tavares-Cadete F.*, Young A. N.*, Sugar R., Schoenfelder S., Ferreira L., Wingett S. , Andrews S., Grey W., Ewels P.A., Herman B., Happe S., Higgs A., LeProust E., Follows G.A., Fraser P., Luscombe N.M., Osborne C.S.

Genome Research; 2015 Apr;25(4):582-97 Schoenfelder S.*, Furlan-Magaril M.*, Mifsud B.*, Tavares-Cadete F.*, Sugar R., Javierre B-M., Nagano T., Katsman Y., Sakthidevi M., Wingett S. W., Dimitrova E., Dimond A., Edelman L. B., Elderkin S., Tabbada K., Darbo E., Andrews S., Herman B., Higgs A., LeProust E., Osborne C.S., Mitchell J.A., Luscombe N.M., Fraser P.

  • 2015 eMedLab Career Development fellowship; Medical Research Council; London/UK
  • 2010 Frontiers in Functional Genomics exchange grant; European Science Foundation; Cambridge/UK
  • 2009 Travel award; European Union Network of Excellence

Dr. Khaled Machaca

Joint Professor

Phone

44928423

Office location

WCMQ C025

Dr. Khaled Machaca

Joint Professor

Educational Qualifications

Ph.D. Cell & Developmental Biology

M.S. Poultry Science

Entity

College of Health and Life Sciences

Biography

Khaled Machaca is Professor of Physiology and Biophysics. He has been training and supervision of Hamad Bin Khalifa University graduate students for the past 5 years. Alongside that, he is a professor at Weill Cornell Medicine and serves as the Senior Associate Dean for Research, Innovation and Commercialization for the Qatar campus. In that capacity he oversees the academic, financial, operational and compliance aspects of the research department, which currently encompasses about 200 researchers. Dr Machaca oversaw the establishment of the administrative and regulatory infrastructure, centralized core laboratories, and faculty recruitment. 

The Machaca Lab is interested in intracellular signaling under physiological and pathological conditions with a focus on calcium signaling. Our goal is to better define these signaling pathways at the cellular and molecular levels to identify potential therapeutic targets in various disease states. We are particularly interested in the role of calcium in cancer, cardiovascular and immune disfunction, as well as in oocyte maturation in preparation for fertilization. Work from the Machaca Lab has been published in leading biomedical journals and garnered continuous extramural funding from NIH and the Qatar National Research Fund (QNRF).  Khaled serves of several editorial boards, reviews widely for scientific journals and granting agencies, and has an extensive track record of training students and postdoctoral fellows.

 

Ph.D. Cell & Developmental Biology

Emory University

1992 - 1996

M.S. Poultry Science

University of Georgia

1990 - 1992

B.S. Agriculture & Diplome D’Ingenieur Agricole

American University of Beirut

1986 - 1990

  • Signal transduction
  • Oocyte maturation
  • Ca2+ signaling
  • Store operated Ca2+ entry
  • Nongenomic progesterone signaling
  • Cellular model for rare genetic disorders

Associate Dean of Research

Weill Cornell Medicine Qatar

2009 - Present

Professor

Department of Physiology & Biophysics, Weill Cornell Medicine

2009 - Present

Director Imaging Core

Weill Cornell Medicine Qatar

2009 - Present

Designated Institutional Official

Weill Cornell Medicine Qatar, Animal Research Program, Weill Cornell Medicine Qatar

2009 - Present

Organizational Official

Weill Cornell Medicine Qatar, Human Research Protection Program (HRPP)

2009 - 2017

Adjunct Professor

Hamad Bin Khalifa University

2016 - Present

Associate Dean for Basic Science Research

Weill Cornell Medicine Qatar

2008 - 2009

Associate Professor

Department of Physiology & Biophysics, University of Arkansas for Medical Sciences (UAMS)

2005 - 2008

Assistant Professor

Department of Physiology & Biophysics, University of Arkansas for Medical Sciences (UAMS)

1999 - 2004

  • 2018, Named Distinguished Alumnus, Emory University Graduate School, Biological and Biomedical Sciences.
  • 2020, Mentoring Award, WCMQ, Excellence in Mentoring in Area of Concentration Medical Student Training.
  • 2022, Organizer and Session Chair, Science Summit at United Nations General Assembly 77 (UNGA77). Personalized Medicine, the Omics Revolution, and Effective Accessible Health Care.
  • 2022, Member, Accreditation and Quality Assurance Committee. High Level committee officially formed in 2022 by the Prime Minister of Qatar through a formal decree to oversee the higher education sector in Qatar.

Dr. Samir Brahim Belhaouari

Associate Professor

Dr. Samir Brahim Belhaouari

Associate Professor

Educational Qualifications

PhD in Mathematical Sciences

MSc in Networks and Telecommunications

Entity

College of Science and Engineering

Division

Information & Computing Technology

Biography

Dr. Samir Belhaouari is an Associate Professor at the College of Science and Engineering at Hamad Bin Khalifa University. He conducts research in various areas, including classification techniques, feature extraction and selection, and data preprocessing. Dr. Belhaouari is developing the multilevel architecture of deep learning (MADL), which optimizes networks at different levels and stages. He has created innovative algorithms for time-frequency decomposition, feature selection, and optimization techniques. Additionally, he explores image and graph representation methods to address complex data challenges and works on compressing deep learning to improve performance while reducing costs and energy consumption.

Additionally, he has developed an enhanced hashing function, drawing inspiration from a mathematical conjecture. His contributions have been recognized through the securing of several national and international research funds, such as HBKU-Thematic and QNRF-NPRP-BSRA. Dr. Belhaouari has served as the principal investigator (PI) and played a significant role in the field of AI. Dr. Belhaouari's work encompasses mathematics, machine learning, data analysis, and classification. His pioneering techniques and algorithms hold great potential for enhancing performance across a wide range of applications.

PhD in Mathematical Sciences

Federal Polytechnic School of Lausanne, (EPFL), Switzerland

2006

MSc in Networks and Telecommunications

National Polytechnic Institute (INP/ENSEEIHT), France

2000

  • Applied mathematics
  • Sustainable AI
  • Image and signal processing
  • Number theory and its application in computer science

Associate Professor

College of Science and Engineering, Hamad Bin Khalifa University

2017 - Present

Associate Professor

College of Science, University of Sharjah, United Arab Emirates

2015 - 2017

Associate Professor

Computer Science College, Innopolis University, Russia

2014 - 2016

Assistant Professor

College of Science and General Studies, Alfaisal University, Saudi Arabia

2012 - 2015

Research Assistant

Laboratory of Stochastic Processes, Federal Polytechnic School of Lausanne, Switzerland

2000 - 2006

Belhaouari, S. B., & AlQudah, R. (2024). Evaluation of the Komlos Conjecture using multi-objective optimization. Contemporary Mathematics.

Rehman, A. U., Belhaouari, S. B., & Bermak, A. (2024). Reinforced steering evolutionary Markov chain for high-dimensional feature selection. Swarm and Evolutionary Computation.

Belhaouari, S. B., Shakeel, M. B., Erbad, A., & Oflaz, Z. (2023). Bird’s Eye View feature selection for high-dimensional data. Scientific Reports.

Rehman, A. U., & Belhaouari, S. B. (2022). Divide well to merge better: A novel clustering algorithm. Pattern Recognition, 122, 108305.

Islam, A., Belhaouari, S. B., Rehman, A. U., & Bensmail, H. (2022). KNNOR: An oversampling technique for imbalanced datasets. Applied Soft Computing, 115, 108288.

Complete Publication Listing(s): Google Scholar

  • Outstanding Research Award (First Position), during the academic year 2014-2015 at the university level, Alfaisal University
  • Gold Medal, Title “Remote Body Temperature Monitoring System for Malaria Patients” in the Geneva exhibition held from 6th to 10th April 2011, Switzerland
  • Silver Prize, Title “BODYTEMPTRAXX”, Seoul International Invention Fair 2010 (SIIF2010), Korea Invention Promotion Association, South Korea
  • The Best Paper Award for University Technology of PETRONAS research paper conference (http://www.urpc2012.blogspot.com/), Title: “A New Novel Model for Prediction of Ionic Liquid Toxicity Based on Quantitative Structure-Activity Relationship Approach” 10 August 2012, Malaysia.
  • Silver Prize, Most Innovative Award, postgraduate category (SEDEX32), Title of the project: An Efficient Computational Intelligence Technique for Protein Sequence Classification in Bioinformatics, December 2013, Malaysia.

Dr. Bo Wang

Associate Professor

Office location

A102D

Dr. Bo Wang

Associate Professor

Educational Qualifications

PhD in Electronic and Computer Engineering

B. Eng in Electrical and Electronic Engineering

Entity

College of Science and Engineering

Division

Information & Computing Technology

Biography

Dr. Bo Wang is an Associate Professor in the College of Science and Engineering at Hamad Bin Khalifa University. He received the B. Eng. degree in Electrical and Electronic Engineering from Zhejiang University, Hangzhou, China, in 2010 and the M. Phil and PhD degrees in Electronic and Computer Engineering from the Hong Kong University of Science and Technology (HKUST), Hong Kong, in 2012 and 2015, respectively.

He worked in RLE, Massachusetts Institute of Technology (MIT) on low-power graphene-based pressure sensor interface design, in 2016. From 2010 to 2015, he was with the Smart Sensory Integrated System Laboratory (s2is) of HKUST as a research assistant and then a research associate. From 2012 to 2014, he also worked as a mixed-signal IC designer in ZAMI, Hangzhou, to commercialize the chip during his PhD research. Dr. Bo Wang is a member of IEEE (CAS Society and SSCS Society).

He received the Best Design Award at the Asia and South Pacific Design Automation Conference (ASP-DAC) in 2016. He also serves as a technical committee member of the IEEE CAS Committee on Sensory Systems and Associate Editor for the IEEE Sensors Journal.

PhD in Electronic and Computer Engineering

Hong Kong University of Science and Technology, China

2015

B. Eng in Electrical and Electronic Engineering

Zhejiang University, China

2010

  • CMOS sensors
  • Mixed-signal IC design
  • Data converters
  • Heterogeneous sensing systems

Associate Professor

College of Science and Engineering, Hamad Bin Khalifa University

2023 - Present

Assistant Professor

College of Science and Engineering, Hamad Bin Khalifa University

2017 - 2023

Research Scientist

Research Laboratory of Electronics (RLE), Massachusetts Institute of Technology, United States

2016 - 2017

Research Associate

Electronic and Computer Engineering (ECE), Hong Kong University of Science and Technology, China

2015

Dr. Saif Mohammed S A Al-Kuwari

Associate Professor

Office location

A 102-C, LAS Building

Dr. Saif Mohammed S A Al-Kuwari

Associate Professor

Educational Qualifications

PhD in Cryptography

PhD in Computational Forensics

Entity

College of Science and Engineering

Division

Information & Computing Technology

Biography

Dr. Saif Al-Kuwari is an associate professor at the College of Science and Engineering and director of the Qatar Center for Quantum Computing (QC2) at Hamad Bin Khalifa University. Dr. Saif Al-Kuwari graduated in computers and networks from the University of Essex and has two PhDs in Cryptography and Computational Forensics from the University of Bath and Royal Holloway, University of London

He is a fellow of IET and BCS and a senior member of IEEE and ACM. His research focuses on quantum cryptography, quantum machine learning, and quantum sensing.

 

PhD in Cryptography

University of Bath, United Kingdom

2012

PhD in Computational Forensics

Royal Holloway, University of London, United Kingdom

2012

BEng in Computers and Networks

University of Essex, United Kingdom

2006

  • Quantum computing
  • Quantum cryptography
  • Quantum machine learning
  • Quantum sensing

Associate Professor

College of Science and Engineering, Hamad Bin Khalifa University

2024 – Present

Assistant Professor

College of Science and Engineering, Hamad Bin Khalifa University

2019 – 2024

Adjunct Assistant Professor

College of Science and Engineering, Hamad Bin Khalifa University

2018 – 2019

Adjunct Research Assistant Professor

Kind Computing Research Center, Qatar University

2018 – 2021

Director

Information Technology Department, Ministry of Foreign Affairs

2013 – 2018

  • 2017; Fellow of the IET.
  • 2017; Fellow of the BCS.
  • 2016 & 2017; MESA-CISO100 Government Security Leader award, UAE.
  • 2012; The PhD platinum prize, 5th Education Excellence Day, Qatar.
  • 2007; The Graduate Platinum prize, 1st Education Excellence Day, Qatar.

Dr. Issam Hmila

Postdoctoral Researcher

Office location

RC-B2-1426

Dr. Issam Hmila

Postdoctoral Researcher

Educational Qualifications

PhD in Biology

MSc in Biochemistry

Entity

Qatar Biomedical Research Institute

Division

Neurological Disorders Research Center

Biography

Dr. Issam Hmila obtained his PhD in Biology between the Vrije Universiteit Brussel, Belgium, and the University of Tunis El Manar, Tunisia in 2010. He obtained an interuniversity diploma in advanced bioinformatics knowledge from the University-Paris Cité, France. He has also completed various courses in biostatistics, immunology, drug design, and discovery from international institutes.

His projects focus on the construction of combinatory libraries, phage display screening, and the engineering of nanobodies for immunotherapy. He was hired as an assistant professor at the Pasteur Institute in 2012, where he developed aptamers and new tools for detecting respiratory viruses of clinical importance in collaboration with the University of Minnesota, USA, and Uppsala University, Sweden. 

In 2017, he joined the Neurological Disorders Research Center at Qatar Biomedical Research Institute, where he conducted his research to develop new tools for therapy against Parkinson's and Alzheimer's diseases based on nanobodies and aptamers. His work focuses on the generation of cortical neurons from induced pluripotent stem cells and the evaluation by global transcriptomic, proteomic, and integrated omics, environmental pollutants, and new drugs with potential Alzheimer's disease modulation.

PhD in Biology

University of Tunis-El Manar, Tunisia

2010

MSc in Biochemistry

University of Tunis-El Manar, Tunisia

2004

  • Drug design and discovery
  • Nanobody and aptamer development and engineering
  • Evaluating the impact of pollutants on brain health
  • Develop diagnostic and therapeutic tools

Postdoctoral Researcher

Qatar Biomedical Research Institute, Hamad bin Khalifa University

2017 - Present

Invited Scientist

College of Veterinary Medicine, University of Minnesota, United States

2014 - 2015

Assistant Professor

Institute Pasteur of Tunis, University of Tunis-El Manar, Tunisia

2012 - 2017

Postdoctoral Researcher

Institute Pasteur of Tunis, University of Tunis-El Manar, Tunisia

2010 - 2012

Perinatal exposure to PFOS and sustained high-fat diet promote neurodevelopmental disorders via genomic reprogramming of pathways associated with neuromotor development. Hmila I, Hill J, Shalaby KE, Ouararhni K, Abedsselem H, Modaresi SMS, Bihaqi SW, Marques E, Sondhi A, Slitt AL, Zawia NH.Ecotoxicol Environ Saf. 2024 Mar 1;272:116070. doi: 10.1016/j.ecoenv.2024.116070. Epub 2024 Feb 9.

Aptamer-Assisted Proximity Ligation Assay for Sensitive Detection of Infectious Bronchitis Coronavirus. Hmila I, Marnissi B, Kamali-Moghaddam M, Ghram A.Microbiol Spectr. 2023 Feb 14;11(1):e0208122. doi: 10.1128/spectrum.02081-22. Epub 2023 Jan 18.

Inhibition of α-Synuclein Seeding-Dependent Aggregation by ssDNA Aptamers Specific to C-Terminally Truncated α-Synuclein Fibrils. Hmila I, Sudhakaran IP, Ghanem SS, Vaikath NN, Poggiolini I, Abdesselem H, El-Agnaf OMA.ACS Chem Neurosci. 2022 Dec 7;13(23):3330-3341. doi: 10.1021/acschemneuro.2c00362. Epub 2022 Nov 8.

Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit in-vitro seeded aggregation and toxicity. Hmila I, Vaikath NN, Majbour NK, Erskine D, Sudhakaran IP, Gupta V, Ghanem SS, Islam Z, Emara MM, Abdesselem HB, Kolatkar PR, Achappa DK, Vinardell T, El-Agnaf OMA.FEBS J. 2022 Aug;289(15):4657-4673. doi: 10.1111/febs.16376. Epub 2022 Feb 25.

A bispecific nanobody to provide full protection against lethal scorpion envenoming. Hmila I, Saerens D, Ben Abderrazek R, Vincke C, Abidi N, Benlasfar Z, Govaert J, El Ayeb M, Bouhaouala-Zahar B, Muyldermans S.FASEB J. 2010 Sep;24(9):3479-89. doi: 10.1096/fj.09-148213. Epub 2010 Apr 21.

  • First place in 2023 QBRI/HBKU research in Focus Day.
  • Intern collaborative project, by Institute Pasteur of Tunis (Tunisia).
  • 2013 early career MENA scientists research grant project (USA).

Dr. Vijay Gupta

Postdoctoral Researcher

Dr. Vijay Gupta

Postdoctoral Researcher

Entity

Qatar Biomedical Research Institute

Division

Neurological Disorders Research Center

Biography

Dr. Vijay Gupta received his Master’s degree in Microbiology from CCS University, Meerut, India and Ph.D. at the Centre for Cellular and Molecular Biology (CCMB), Hyderabad, INDIA (2006). Dr. Gupta was awarded ASCB pre-doctoral travel award to attend ASCB annual meeting in 2005, Carl Storm International Diversity Fellowship to attend the Gordon Research Conference in University of New England, Maine, USA 2006 and later on Royal Society International Incoming Fellowship (2006) from the Royal Society, London, UK to perform research at The University of Bristol where he worked for fifteen months with the honorary title of Royal Society International Research fellow. He joined The Scripps Research Institute, La Jolla, USA on Target Characterization Fellowship funded by Cystic Fibrosis Foundation, USA as CF fellow for five years and then moved to University of California, San Diego as Assistant Project Scientist where he worked till June, 2017.

Dr. Gupta has multidisciplinary research experience in the fields of protein trafficking, cancer and human genetic diseases and has published more than fifteen publications including top-tier journals such as Nature Chemical biology, Developmental Cell, PNAS, JCS and Traffic. He is an invited member of Sigma Xi- Scientific Honor Society, elected 2013, invited member of Cell Stress Society International (CSSI), USA, peer review board member of JoVe and Dove press and has reviewed more than thirty manuscripts. One of the hobbies of Dr. Gupta is popular science writing for the general public, aimed at raising scientific awareness.

 

Common neurodegenerative diseases such as Parkinson’s Disease, Dementia with Lewy Bodies (DLB) and Multiple System Atrophy (MSA) are characterized by progressive deposition of α-synuclein (α-syn) protein within inclusions referred to as Lewy bodies and glial cytoplasmic inclusions respectively. Amongst the various approaches attempting to tackle the pathological features of synucleinopathies, immunotherapy holds much promise. α-Syn antibodies could potentially block processes leading to the pathogenesis of such neurodegenerative diseases. The limitation of such antibodies is their inefficiency in crossing the Blood-Brain Barrier (BBB). Dr. Gupta’s research interests lies in designing a variety of strategies to develop efficient antibodies or similar molecules with superior BBB cross over capacities.

  • The aim of the current research project focuses on using a fusion protein engineered to include the FAb region of existing α-Syn antibodies. This single-chain-fragment-variable is designed to have increased BBB penetration by virtue of its smaller size and its conjugation with a carrier. It is envisaged that with enhanced penetration there will be superior brain targeting results compared to conventional α-syn antibodies.

Farquhar and Pradipta Ghosh. “GIV/Girdin activates Gαi and inhibits Gαs via the same motif”. PNAS. 2016 Sep 27;113(39):E5721-30.

Farquhar and Pradipta Ghosh, “CDK5 Activates Guanine Nucleotide Exchange Factor GIV/Girdin to Orchestrate Migration-Proliferation Dichotomy”. PNAS, 2015 Sep 1;112:E4874-83.

Farquhar,* and Pradipta Ghosh * “Activation of Gi at the Golgi by GIV/Girdin Imposes Finiteness in Arf1 Signaling”. Dev. Cell 33, 1–15, April 20, 2015.

J Proteome Res. 2014 13 (11), PP 4668-4675.

2013 Jan; 9(1):12-4.

“Kinesin-1 (uKHC/KIF5B) is required for bidirectional motility of ER exit sites and efficient ER-to-Golgi transport” Traffic, Volume 9, Issue 11 , Pages 1850-66, (2008).

Pubmed link