Dr. Kholoud K. Saleh

Dr. Kholoud K. Saleh

Research Associate

Dr. Kholoud K. Saleh

Research Associate

Educational Qualifications

PhD in Molecular, Cellular and Integrative Physiology

Bachelor’s degree in science, Biological Sciences

Entity

College of Health and Life Sciences

Biography

Dr. Saleh obtained her bachelor’s degree in Biological Sciences from Qatar University in 2014. She later joined the Ardehali Laboratory as a visiting scientist at David Geffen School of Medicine at University of California-Los Angeles (UCLA). She participated in the characterization of cardiovascular progenitor cells derived from human pluripotent stem cells. Dr. Saleh then joined Dr. Apil Pyle Laboratory as a Graduate Student Researcher; she investigated how Duchenne Muscular Dystrophy disease severity, in mouse models, impacts the systemic delivery of human skeletal muscle progenitor cells. She obtained her PhD in Molecular, Cellular and Integrative Physiology from UCLA in 2022. 

PhD in Molecular, Cellular and Integrative Physiology

University of California Los Angeles, USA

2022

Bachelor’s degree in science, Biological Sciences

Qatar University, Qatar

2014

Pre-Medical Program

Weill Cornell Medical College, Qatar

2007 - 2010

  • Human Pluripotent Stem Cells and their differentiation to Muscle Progenitor Cells
  • Muscle Physiology
  • Insulin Resistance
  • Lipid metabolism

Graduate Student Researcher

Pyle Laboratory, UCLA

April 2017 - July 2022

UCLA Teaching Assistantship Physiology and Human Biology

UCLA

Spring 2018 and Spring 2019

Visiting Scholar Researcher

Ardehali Laboratory, UCLA

Nov 2014 - Dec 2016

Undergraduate Researcher

Qatar University

2013 - 2014

Summer Undergraduate Researcher

Kotter Laboratory at Anne McLaren Laboratory for Regenerative Medicine at Cambridge University

Summer 2013

  • 2020, Biomedical, Life Sciences and Health Sciences Research Award, UCLA David Geffen School of Medicine, USA.
  • 2016 - 2022, Qatar Research Leadership Program (QRLP) - Graduate Research Scholar Fellowship, QNRF, Qatar.
  • 2014 - 2016, Qatar Research Leadership Program (QRLP) - Management Track Fellowship, QNRF, Qatar.
  • 2013 - 2014, Qatar Science Leadership Program - Undergraduate Track Fellowship, QF, Qatar.
Ali Ait Hssain

Dr. Ali Ait Hssain

Adjunct Clinical Associate Professor

Dr. Ali Ait Hssain

Adjunct Clinical Associate Professor

Educational Qualifications

French Board of Clinical Nutrition(Diplôme d’Études Spécialisés Complémentaires de Nutrition Clinique)

Master of Science:Human Nutrition and Food Science

Entity

College of Health and Life Sciences

Biography

Dr. Ali Ait Hssain is a senior consultant intensivist and member of the ECMO Team at Hamad General Hospital, in Doha, Qatar. He has supervised PhD students at HBKU and is involved in clinical research including ICU patients with various diseases. He has also contributed to the Covid 19 diagnosis research with other colleagues at HBKU.

Alongside this, Dr. Hssain is an assistant Professor of Clinical Medicine at Weill Cornell Medical College. He received his medical degree and completed his residency of anesthesiology and critical care medicine in France.

Dr. Ali Ait Hssain has more than 20 years’ experience in Critical Care Medicine from different countries. He served as assistant clinical professor in university d’Auvergne in Clermont Ferrand, France. He was at the origin of the launch of the ECMO program in his center in 2007. 

He is involved in several multicenter trials as investigator in international and multicenter collaborative projects with academic institutions. He is the author of more than 80 papers and book chapters. He is the actual lead for research at the medical intensive care unit. He is the lead for the ECMO Simulation Team of Doha (ECSiTeD) and therefore advocating for Simulation Based training for interprofessional development.

 

French Board of Clinical Nutrition(Diplôme d’Études Spécialisés Complémentaires de Nutrition Clinique)

Medicine Faculty of Clermont Ferrand Auvergne University, FRANCE

2012

Master of Science:Human Nutrition and Food Science

Auvergne University, FRANCE

2007

French Board of Intensive Care Medicine and Anesthesiology

Medicine Faculty of Limoges Limoges’ University, FRANCE

2006

  • ExtraCorporeal Membrane Oxygenation (ECMO)
  • Critical Care
  • Sepsis
  • Nutrition

Clinical Assistant Professor

Weil Cornell Medical College, Qatar

August 2020 - Present

Consultant Intensivist

Department of Nephrology, Hemodialysis, Transplantation and Intensive Care Medicine, Hospital Gabriel Montpied, Teaching Hospital, Clermont Ferrand, France

2006 - 2015

Senior Consultant Intensivist

Department of medicine - Medical Intensive Care Unit/ECMO Team Hamad General Hospital Doha, Qatar

December 2014 - Present

Clinical Assistant Professor of Medicine

Faculty of medicine of Clermont Ferrand, Université d’Auvergne, France

2006 - 2009

Elmelliti H, Azimi AV, Albazoon F, Alqahwachi H, Akbar A, Shehata AL, Hassan IF, Ibrahim AS, Ait Hssain A. Outcomes of patients with in- and out-of-hospital cardiac arrest on extracorporeal cardiopulmonary resuscitation: A Single-Center Retrospective Cohort Study. Curr Probl Cardiol. 2022 Dec 29:101578.

Bakdach D, Elajez R, Bakdach AR, Awaisu A, De Pascale G, Ait Hssain A. Pharmacokinetics, Pharmacodynamics, and Dosing Considerations of Novel β-Lactams and β-Lactam/β-Lactamase Inhibitors in Critically Ill Adult Patients: Focus on Obesity, Augmented Renal Clearance, Renal Replacement Therapies, and Extracorporeal Membrane Oxygenation. J Clin Med. 2022 Nov 22;11(23):6898.

Bradic M, Taleb S, Thomas B, Chidiac O, Robay A, Hassan N, Malek J, Ait Hssain A, Abi Khalil C. DNA methylation predicts the outcome of COVID-19 patients with acute respiratory distress syndrome. J Transl Med. 2022 Nov 12;20(1):526.

Martucci G, Schmidt M, Agerstrand C, Tabatabai A, Tuzzolino F, Giani M, Ramanan R, Grasselli G, Schellongowski P, Riera J, Ait Hssain A, Duburcq T, Gorjup V, De Pascale G, Buabbas S, Gannon WD, Jeon K, Trethowan B, Fanelli V, Chico JI, Balik M, Broman LM, Pesenti A, Combes A, Ranieri MV, Foti G, Buscher H, Tanaka K, Lorusso R, Arcadipane A, Brodie D; International ECMO Network (ECMONet).Transfusion practice in patients receiving VV ECMO (PROTECMO): a prospective, multicentre, observational study. Lancet Respir Med. 2022 Oct 11:S2213-2600(22)00353-8.

Al-Badriyeh D, Ait Hssain A, Abushanab D. Cost-Effectiveness Analysis of Out-Of-Hospital versus In-Hospital Extracorporeal Cardiopulmonary Resuscitation for Out-Hospital Refractory Cardiac Arrest. Curr Probl Cardiol. 2022 Sep 4:101387.

Khaled Machaca

Dr. Khaled Machaca

Joint Professor

Phone

44928423

Office location

WCMQ C025

Dr. Khaled Machaca

Joint Professor

Educational Qualifications

Ph.D. Cell & Developmental Biology

M.S. Poultry Science

Entity

College of Health and Life Sciences

Biography

Khaled Machaca is Professor of Physiology and Biophysics. He has been training and supervision of Hamad Bin Khalifa University graduate students for the past 5 years. Alongside that, he is a professor at Weill Cornell Medicine and serves as the Senior Associate Dean for Research, Innovation and Commercialization for the Qatar campus. In that capacity he oversees the academic, financial, operational and compliance aspects of the research department, which currently encompasses about 200 researchers. Dr Machaca oversaw the establishment of the administrative and regulatory infrastructure, centralized core laboratories, and faculty recruitment. 

The Machaca Lab is interested in intracellular signaling under physiological and pathological conditions with a focus on calcium signaling. Our goal is to better define these signaling pathways at the cellular and molecular levels to identify potential therapeutic targets in various disease states. We are particularly interested in the role of calcium in cancer, cardiovascular and immune disfunction, as well as in oocyte maturation in preparation for fertilization. Work from the Machaca Lab has been published in leading biomedical journals and garnered continuous extramural funding from NIH and the Qatar National Research Fund (QNRF).  Khaled serves of several editorial boards, reviews widely for scientific journals and granting agencies, and has an extensive track record of training students and postdoctoral fellows.

 

Ph.D. Cell & Developmental Biology

Emory University

1992 - 1996

M.S. Poultry Science

University of Georgia

1990 - 1992

B.S. Agriculture & Diplome D’Ingenieur Agricole

American University of Beirut

1986 - 1990

  • Signal transduction
  • Oocyte maturation
  • Ca2+ signaling
  • Store operated Ca2+ entry
  • Nongenomic progesterone signaling
  • Cellular model for rare genetic disorders

Associate Dean of Research

Weill Cornell Medicine Qatar

2009 - Present

Professor

Department of Physiology & Biophysics, Weill Cornell Medicine

2009 - Present

Director Imaging Core

Weill Cornell Medicine Qatar

2009 - Present

Designated Institutional Official

Weill Cornell Medicine Qatar, Animal Research Program, Weill Cornell Medicine Qatar

2009 - Present

Organizational Official

Weill Cornell Medicine Qatar, Human Research Protection Program (HRPP)

2009 - 2017

Adjunct Professor

Hamad Bin Khalifa University

2016 - Present

Associate Dean for Basic Science Research

Weill Cornell Medicine Qatar

2008 - 2009

Associate Professor

Department of Physiology & Biophysics, University of Arkansas for Medical Sciences (UAMS)

2005 - 2008

Assistant Professor

Department of Physiology & Biophysics, University of Arkansas for Medical Sciences (UAMS)

1999 - 2004

  • 2018, Named Distinguished Alumnus, Emory University Graduate School, Biological and Biomedical Sciences.
  • 2020, Mentoring Award, WCMQ, Excellence in Mentoring in Area of Concentration Medical Student Training.
  • 2022, Organizer and Session Chair, Science Summit at United Nations General Assembly 77 (UNGA77). Personalized Medicine, the Omics Revolution, and Effective Accessible Health Care.
  • 2022, Member, Accreditation and Quality Assurance Committee. High Level committee officially formed in 2022 by the Prime Minister of Qatar through a formal decree to oversee the higher education sector in Qatar.
Dr. Nayef Mazloum

Dr. Nayef Mazloum

Adjunct Associate Professor

Office location

C014, South Hall, WCM-Q

Dr. Nayef Mazloum

Adjunct Associate Professor

Educational Qualifications

PhD in Biochemistry and Molecular Biology

BS in Biology

Entity

College of Health and Life Sciences

Biography

Dr. Nayef A. Mazloum is an Adjunct Associate Professor at Hamad Bin Khalifa University. He graduated from the American University of Beirut in 1994 and completed his PhD in biochemistry and molecular biology at New York Medical College in Valhalla in 2003.

Dr. Nayef A. Mazloum worked as an instructor of microbiology and immunology at Weill Cornell Medical College in New York. He did his postdoctoral training at Memorial Sloan Kettering Cancer Center and worked at Weill Cornell Medicine-Qatar (WCM-Q).

Dr. Mazloum’s research focuses on the molecular aspects of DNA repair mechanisms, the stability of the genome, and how the dysfunction of these regulatory pathways could lead to cancer, age-related or metabolic diseases.

His lab employs cellular, molecular, and genetic tools to investigate altered molecular pathways in metabolic disorders and cancer. Dr. Mazloum actively collaborates with local stakeholders in Qatar, including Hamad Medical Corporation, Qatar University, Texas A&M University, Qatar Biomedical Research Institute, and Hamad Bin Khalifa University. He also collaborates with global investigators at Harvard Medical School, Mayo Clinic, Brown University, and the University of East Anglia.

PhD in Biochemistry and Molecular Biology

New York Medical College, Valhalla, United States

2003

BS in Biology

American University of Beirut, Lebanon

1994

  • Function of Sirt1 in adipocyte proliferation and differentiation
  • Molecular mechanisms regulated by the oncogene C-Myc
  • Mechanisms of cellular senescence in Obesity and Diabetes
  • Function of the E3 ubiquitin-protein Ligase UHRF1

Adjunct Associate Professor

College of Health and Life Sciences, Hamad Bin Khalifa University

2025 - Present

Associate Professor of Microbiology and Immunology

Research, Weill Cornell Medicine Qatar

2024 - Present

Assistant Professor

College of Health and Life Sciences, Hamad Bin Khalifa University

2015 - 2025

Assistant Dean for Student Research

Weill Cornell Medicine Qatar, Weill Cornell Medicine Qatar

2017 - Present

Assistant Professor of Microbiology and Immunology

Research, Weill Cornell Medicine Qatar

2011 - 2024

Instructor

Microbiology and Immunology, Weill Cornell Medicine New York, United States

2008 - 2010

Postdoctoral Research Associate

Microbiology and Immunology, Weill Cornell Medicine New York, United States

2004 - 2010

Vakayil, M., Madani, A. Y., Agha, M. V., Majeed, Y., Hayat, S., Yonuskunju, S., Mohamoud, Y. A., Malek, J., Suhre, K., & Mazloum, N. A. (2024). The E3 ubiquitin-protein ligase UHRF1 promotes adipogenesis and limits fibrosis by suppressing GPNMB-mediated TGF-β signaling. Scientific Reports, 14(1), 11886.

Majeed, Y., Madani, A. Y., Altamimi, A. I., Courjaret, R., Vakayil, M., Fountain, S. J., Machaca, K., & Mazloum, N. A. (2023). STAT1- and NFAT-independent amplification of purinoceptor function integrates cellular senescence with interleukin-6 production in preadipocytes. British Journal of Pharmacology, 180(5), 609–627.

Majeed, Y., Halabi, N., Madani, A. Y., Engelke, R., Bhagwat, A. M., Abdesselem, H., Agha, M. V., Vakayil, M., Courjaret, R., Goswami, N., Hamidane, H. B., Elrayess, M. A., Rafii, A., Graumann, J., Schmidt, F., & Mazloum, N. A. (2021). SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways. Scientific Reports, 11(1), 8177.

Madani, A. Y., Majeed, Y., Abdesselem, H. B., Agha, M. V., Vakayil, M., Sukhun, N. K. A., Halabi, N. M., Kumar, P., Hayat, S., Elrayess, M. A., Rafii, A., Suhre, K., & Mazloum, N. A. (2021). Signal Transducer and Activator of Transcription 3 (STAT3) suppresses STAT1/interferon signaling pathway and inflammation in senescent preadipocytes. Antioxidants, 10(2), 1–25.

Al-Sulaiti, H., Diboun, I., Agha, M. V., Mohamed, F. F. S., Atkin, S., Dömling, A. S., Elrayess, M. A., & Mazloum, N. A. (2019). Metabolic signature of obesity-associated insulin resistance and type 2 diabetes. Journal of Translational Medicine, 17(1), 348.

Complete Publication Listing(s): PubMed

  • 2000; First Prize Winner, Annual Graduate Student Research Forum, NYMC.
  • 1991; Harriri Foundation Scholarship Award, AUB.
Umm-Kulthum Ismail Umlai

Dr. Umm-Kulthum Ismail Umlai

Post-doctoral Researcher

Dr. Umm-Kulthum Ismail Umlai

Post-doctoral Researcher

Educational Qualifications

PhD in Genomics and Precision Medicine

Master in Biomedical Research

Entity

College of Health and Life Sciences

Biography

Umm-Kulthum is an early career researcher with experience in genomics, metagenomics, biomedical research and metabolomics. She spent most of her life in Qatar where she also graduated with research honours from Carnegie Mellon University located at the prestigious Education City. Her postgraduate experience involved several biomedical research projects including metabolomics of Alzheimer’s disease and liver diseases at Imperial College of Science, Technology and Medicine in the UK. Her PhD research with Hamad Bin Khalifa University was a combination of clinical and genomics research, looking into the genetics underlying rare growth disorders in paediatric patients recruited from a hospital in Qatar. Currently, Umm-Kulthum is working as a post-doctoral researcher with Professor Omar Albagha where she is involved in numerous Genome-Wide Association Studies projects which utilize the Qatar Genome Programme data to investigate various traits.

PhD in Genomics and Precision Medicine

Hamad Bin Khalifa University (Doha, Qatar)

2022

Master in Biomedical Research

Imperial College of Science Technology and Medicine (London, England)

2017

Bachelor in Biological Sciences

Carnegie Mellon University (Doha, Qatar)

2016

Post-Doctoral Researcher

Hamad Bin Khalifa University (Doha, Qatar)

2022 - Present

Teaching Assistant Pharmacogenomics Course

Hamad Bin Khalifa University (Doha, Qatar)

2021 - 2021

Research Assistant

Queen Mary University of London, (London, England)

2016 - 2017

Research Student

Biological Sciences Department, Carnegie Mellon University (Doha, Qatar)

2014 - 2016

Summer Research Fellow

Mellon College of Science, Carnegie Mellon University (Pittsburgh, USA)

2013

  • Hamad Bin Khalifa University sponsored PhD scholarship from Hamad Bin Khalifa University (Doha, Qatar), 2018 - 2022.
  • Research Honors from Research Honors, 2016.
  • Meeting of the Minds- 3rd place annual research showcase from Carnegie Mellon University (Doha, Qatar), 2015.
  • Annual Research Award- 1st place student poster (Energy and Environment category) from Annual Research Conference Qatar Foundation, 2014.
Dr. Zubair Shah

Dr. Zubair Shah

Assistant Professor

Office location

A-101F

Dr. Zubair Shah

Assistant Professor

Educational Qualifications

PhD in Data Science

MSc in Computer System Engineering

Entity

College of Science and Engineering

Division

Information & Computing Technology

Biography

Dr. Zubair Shah is an Assistant Professor in the College of Science and Engineering specializing in artificial intelligence and big data analytics with a focus on health informatics. He holds an MS degree in Computer System Engineering from Politecnico di Milano, Italy, and a PhD from the University of New South Wales, Australia. Before joining HBKU, Dr. Shah was a Research Fellow at the Australian Institute of Health Innovation, Macquarie University, from 2017 to 2019.

Dr. Shah's research focuses on applying AI to healthcare, particularly in developing AI-driven applications that enhance disease diagnosis and prediction. He has secured critical funding from HBKU Innovation Center and QNRF to advance these efforts, including work on diabetes management and multimodal AI systems combining electronic health records (EHR), medical imaging, and multi-omics data. His team has developed innovative deep-learning techniques, including methods for identifying IDH mutations from histopathology slides and exploring the use of generative models like GANs and neural diffusion for medical data augmentation.

Dr. Shah has published extensively in leading international journals and conferences, and his research also explores the potential of foundation AI models in healthcare, contributing significantly to advancements in AI-powered medical diagnostics.

PhD in Data Science

University of New South Wales, Australia

2017

MSc in Computer System Engineering

Politecnico Di Milano, Italy

2011

BS in Computer Science

University of Peshawar, Pakistan

2005

  • Digital Epidemiology and behavioral analysis of vaccination attitudes
  • AI-driven healthcare applications
  • Deep learning in medical imaging
  • Generative models for medical data

Assistant Professor

College of Science and Engineering, Hamad Bin Khalifa University

2019 - Present

Research Fellow

Australian Institute of Health Innovation, Macquarie University, Australia

2017 - 2019

Lecturer

Computer Science, City University of Science and Information Technology, Pakistan

2012 - 2013

System Engineer

National Database and Registration Authority, Pakistan

2006 - 2009

Mohsen, F., Al-Absi, H. R. H., Yousri, N. A., El Hajj, N., & Shah, Z. (2023). A scoping review of artificial intelligence-based methods for diabetes risk prediction. NPJ Digital Medicine, 6(1), 197.

Mohsen, F., Ali, H., El Hajj, N., & Shah, Z. (2022). Artificial intelligence-based methods for fusion of electronic health records and imaging data. Scientific Reports, 12(1), 17981.

Ahmad, W., Ali, H., Shah, Z., & Azmat, S. (2022). A new generative adversarial network for medical images super resolution. Scientific Reports, 12(1), 1–20.

Shah, U., Biswas, M. R., Ali, R., Ali, H., & Shah, Z. (2022). Public attitudes on social media toward vaccination before and during the COVID-19 pandemic. Human Vaccines & Immunotherapeutics, 18(6), 2101835.

Liu, S., Shah, Z., Sav, A., Russo, C., Berkovsky, S., Qian, Y., Coiera, E., & Di Ieva, A. (2020). Isocitrate dehydrogenase (IDH) status prediction in histopathology images of gliomas using deep learning. Scientific Reports, 10(1), 7733.

  • 2016 Postgraduate Research Student Support (PRSS), UNSW, Australia
  • 2014 University College Postgraduate Research Scholarship (UCPRS), UNSW, Australia
  • 2009 DSU-International Postgraduate Scholarship, Politecnico di Milano, Italy
  • 2005 Distinction at Department of Computer Science, University of Peshawar, Pakistan 
Dr. Afif Ben Mahmoud

Dr. Afif Ben Mahmoud

Senior Research Associate

Office location

C142 / RC-B2-1127

Dr. Afif Ben Mahmoud

Senior Research Associate

Educational Qualifications

PhD (Molecular and Human Genetics)

MSc in Genetics and Biodiversity

Entity

Qatar Biomedical Research Institute

Division

Neurological Disorders Research Center

Biography

Dr. Afif Ben Mahmoud is an accomplished geneticist and genome data analyst with extensive expertise in human molecular genetics. He earned an engineering degree in agriculture and animal production, a master's in genetics and biodiversity, and a PhD in molecular and human genetics. With over 12 years of experience in research and academia, Dr. Ben-Mahmoud has dedicated his work to elucidating cellular and molecular mechanisms underlying human genetic diseases, focusing on identifying disease genes and mutations responsible for rare recessive disorders, particularly in Arab populations.

His professional contributions in genetic pathology span from phenotypic and genotypic characterization of patients with monogenic diseases to functional studies aimed at demonstrating the pathogenicity of disease-causing novel genes and gene variations. He has also led numerous projects to decode rare human monogenic diseases, significantly advancing the field. 


Dr. Afif Ben Mahmoud’s notable accomplishments include the first functional analysis of B3GALTL in Tunisian patients with Peters Plus Syndrome, the identification of MAST1 as a novel intellectual disability gene, and confirming the role of B3GALT6 in Al-Gazali Syndrome. Additionally, he has identified 16 autosomal dominant candidate genes in syndromic neurodevelopmental disorders and new candidate loci for intellectual disability and Kallmann syndrome. Dr. Ben-Mahmoud has published 25 high-quality articles in renowned international peer-reviewed journals, with over 500 citations and an h-index of 14.

PhD (Molecular and Human Genetics)

Sfax University, Tunisia

2015

MSc in Genetics and Biodiversity

Monastir University, Tunisia

2009

Engineering in Agriculture and Animal Production

Carthage University, Tunisia

2007

  • Identification of novel disease genes and their pathogenic variants in autism and human monogenic diseases in Qatar.
  • Investigation of genetic diversity and recessive disorders in Arab populations in Qatar.
  • Functional validation of novel genes associated with intellectual disability and autism spectrum disorder in the Qatari population.
  • Elucidation of cellular and molecular mechanisms in syndromic neurodevelopmental disorders in Qatar.

Senior Research Associate

Qatar Biomedical Research Institute, Hamad Bin Khalifa University

2019 - present

PostDoc Researcher

College of Medicine & Health Sciences, United Arab Emirates University, UAE

2016 - 2018

Ben-Mahmoud, A., Kishikawa, S., Gupta, V., Leach, N. T., Shen, Y., Moldovan, O., Goel, H., Hopper, B., Ranguin, K., Gruchy, N., Maas, S. M., Lacassie, Y., Kim, S. H., Kim, W. Y., Quade, B. J., Morton, C. C., Kim, C. H., Layman, L. C., & Kim, H. G. (2023). A cryptic microdeletion del(12)(p11.21p11.23) within an unbalanced translocation t(7;12)(q21.13;q23.1) implicates new candidate loci for intellectual disability and Kallmann syndrome. Scientific Reports, 13(1), Article 12984.

Ben-Mahmoud, A., Gupta, V., Kim, C.-H., Layman, L. C., & Kim, H.-G. (2023). Digenic or oligogenic mutations in presumed monogenic disorders: A review. Journal of Genetic Medicine, 20(1), 15–24.

Ben-Mahmoud, A., Jun, K. R., Gupta, V., Shastri, P., de la Fuente, A., Park, Y., Shin, K. C., Kim, C. A., da Cruz, A. D., Pinto, I. P., Minasi, L. B., Silva da Cruz, A., Faivre, L., Callier, P., Racine, C., Layman, L. C., Kong, I. K., Kim, C. H., Kim, W. Y., & Kim, H. G. (2022). A rigorous in silico genomic interrogation at 1p13.3 reveals 16 autosomal dominant candidate genes in syndromic neurodevelopmental disorders. Frontiers in Molecular Neuroscience, 15, Article 979061.

Ben-Mahmoud, A., Al-Shamsi, A. M., Ali, B. R., & Al-Gazali, L. (2020). Evaluating the role of MAST1 as an intellectual disability disease gene: Identification of a novel de novo variant in a patient with developmental disabilities. Journal of Molecular Neuroscience, 70(3), 320–327.

Ben-Mahmoud, A., Ben-Salem, S., Al-Sorkhy, M., John, A., Ali, B. R., & Al-Gazali, L. (2018). A B3GALT6 variant in a patient originally described as Al-Gazali syndrome and implicating the endoplasmic reticulum quality control in the mechanism of some β3GalT6-pathy mutations. Clinical Genetics, 93(6), 1148–1158.

  • 2018; Researchers at UAEU develop cell lines with gene-editing technology CRISPR-Cas9 used to understand diseases
Dr. Nehad Alajez

Dr. Nehad Alajez

Principal Investigator

Joint Professor

Dr. Nehad Alajez

Principal Investigator

Joint Professor

Educational Qualifications

PhD

MSc

Entity

Qatar Biomedical Research Institute

College of Health and Life Sciences

Division

Translational Oncology Research Center

Biography

Dr. Nehad Alajez earned his PhD in tumour immunology from the University of Pittsburgh School of Medicine in USA, and subsequently completed his post-doctoral training at the Princess Margaret Cancer Center (University Health Network), a premier cancer research institute in Canada. His main research interest is to investigate the role of the Polycomb gene family and non-coding microRNAs in driving cancer progression and their potential utilization for targeted therapies. Dr. Alajez is a recipient of several prestigious awards and has published more than 100 articles in top-tier ISI-indexed journals including Blood, Cancer Research, Cell Death and Differentiation, Cell Death and Disease, Signal Transduction and Targeted Therapy, Molecular Therapy (family journals), EMBO Molecular Medicine, and in Science Translational Medicine. Dr. Alajez currently has close to 5000 citations and an h-index of 35 and i10-index of 74.

Prior to his current appointment, Dr. Alajez was appointed as the Associate Professor at King Saud University College of Medicine, Kingdom of Saudi Arabia. Dr. Alajez’s main research interests are focused on ‘translational oncology research’ with main emphasis on novel biomarker discovery and targeted therapeutics for breast cancers. In particular, Dr. Alajez’s team is studying noncoding RNAs (micoRNAs and lncRNAs) as disease and predictive biomarkers for patients’ response to therapy. Dr. Alajez has strong expertise in transcriptome analysis, noncoding RNAs, and biomarker discovery field and is currently ranked among the top 2% most cited scientist globally. He is a recipient of several major grants, including funding from Qatar National Research Fund, in addition to his editorial roles on several journals.

 

PhD

University of Pittsburgh, USA

2003

MSc

San Francisco State University, USA

1999

BSc

Islamic University of Gaza, Palestine

1995

Dr. Alajez main research interests are focused on precision medicine aiming at the discovery of novel tumour and circulating biomarkers for breast cancer diagnosis, prognosis, and therapy. Additionally, Dr. Alajez’s group is conducting CRISPR-Cas9 genomic screens to elucidate the role of miRNAs and lncRNAs in driving breast cancer survival and resistance to standard therapies.

  • Identification of molecular signatures predictive of pathological complete response to neoadjuvant therapy in breast cancer.
  • Identification of circulating miRNAs as diagnostic and predictive biomarkers for breast cancer.
  • Transcriptomic profiling of breast cancer for diagnostic
  • prognostic
  • and therapeutic applications.
  • CRISPR-Cas9 genomic screen to identify novel therapeutic vulnerabilities in breast cancer.

Principal Investigator

Translational Oncology Research Center, Qatar Biomedical Research Institute

2022 - Present

Senior Scientist

Translational Cancer and Immunity Center, Qatar Biomedical Research Institute

2018 - 2022

Associate Professor

College of Medicine, King Saud University

2015 - 2018

Assistant Professor

College of Medicine, King Saud University

2011 - 2015

Vishnubalaji R, Shaath H, Al-Alwan M, Abdelalim EM, Alajez NM. Reciprocal interplays between MicroRNAs and pluripotency transcription factors in dictating stemness features in human cancers. Semin Cancer Biol 2022;87:1-16.

Vishnubalaji R, Abdel-Razeq H, Gehani S, Albagha OME, Alajez NM. Identification of a Gene Panel Predictive of Triple-Negative Breast Cancer Response to Neoadjuvant Chemotherapy Employing Transcriptomic and Functional Validation. Int J Mol Sci 2022;23(18).

Shaath H, Vishnubalaji R, Elango R, Kardousha A, Islam Z, Qureshi R, et al. Long non-coding RNA and RNA-binding protein interactions in cancer: Experimental and machine learning approaches. Semin Cancer Biol 2022;86(Pt 3):325-45.

Vishnubalaji R, Alajez NM. Transcriptional landscape associated with TNBC resistance to neoadjuvant chemotherapy revealed by single-cell RNA-seq. Mol Ther Oncolytics 2021;23:151-62.

Shaath H, Vishnubalaji R, Elango R, Khattak S, Alajez NM. Single-cell long noncoding RNA (lncRNA) transcriptome implicates MALAT1 in triple-negative breast cancer (TNBC) resistance to neoadjuvant chemotherapy. Cell Death Discov 2021;7(1):23.

Elango R, Vishnubalaji R, Shaath H, Alajez NM. Molecular subtyping and functional validation of TTK, TPX2, UBE2C, and LRP8 in sensitivity of TNBC to paclitaxel. Mol Ther Methods Clin Dev 2021;20:601-14.

Alajez NM. COVID-19: complexity of disease severity revealed by systemic and localized single cell immune atlas. Signal Transduct Target Ther 2021;6(1):156.

Vishnubalaji R, Shaath H, Elango R, Alajez NM. Noncoding RNAs as potential mediators of resistance to cancer immunotherapy. Semin Cancer Biol 2020;65:65-79.

Shaath H, Vishnubalaji R, Elkord E, Alajez NM. Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19. Cells 2020;9(11).

Sasidharan Nair V, Toor SM, Taouk G, Pfister G, Ouararhni K, Alajez NM, et al. Pembrolizumab Interferes with the Differentiation of Human FOXP3(+)-Induced T Regulatory Cells, but Not with FOXP3 Stability, through Activation of mTOR. J Immunol 2020;204(1):199-211.

Hanieh H, Ahmed EA, Vishnubalaji R, Alajez NM. SOX4: Epigenetic regulation and role in tumorigenesis. Semin Cancer Biol 2020;67(Pt 1):91-104.

Elango R, Alsaleh KA, Vishnubalaji R, Manikandan M, Ali AM, Abd El-Aziz N, et al. MicroRNA Expression Profiling on Paired Primary and Lymph Node Metastatic Breast Cancer Revealed Distinct microRNA Profile Associated With LNM. Front Oncol 2020;10:756.

Vishnubalaji R, Shaath H, Elkord E, Alajez NM. Long non-coding RNA (lncRNA) transcriptional landscape in breast cancer identifies LINC01614 as non-favorable prognostic biomarker regulated by TGFbeta and focal adhesion kinase (FAK) signaling. Cell Death Discov 2019;5:109

Vishnubalaji R, Elango R, Al-Toub M, Manikandan M, Al-Rikabi A, Harkness L, et al. Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B. Sci Rep 2019;9(1):8101

Elango R, Vishnubalaji R, Manikandan M, Binhamdan SI, Siyal AA, Alshawakir YA, et al. Concurrent targeting of BMI1 and CDK4/6 abrogates tumor growth in vitro and in vivo. Sci Rep 2019;9(1):13696

Hamam R, Hamam D, Alsaleh KA, Kassem M, Zaher W, Alfayez M, et al. Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers. Cell Death Dis 2017;8(9):e3045

Vishnubalaji R, Hamam R, Yue S, Al-Obeed O, Kassem M, Liu FF, et al. MicroRNA-320 suppresses colorectal cancer by targeting SOX4, FOXM1, and FOXQ1. Oncotarget 2016;7(24):35789-802.

Hamam R, Ali AM, Alsaleh KA, Kassem M, Alfayez M, Aldahmash A, et al. microRNA expression profiling on individual breast cancer patients identifies novel panel of circulating microRNA for early detection. Sci Rep 2016;6:25997.

Vishnubalaji R, Hamam R, Abdulla MH, Mohammed MA, Kassem M, Al-Obeed O, et al. Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer. Cell Death Dis 2015;6(1):e1614.

Ito E, Yue S, Moriyama EH, Hui AB, Kim I, Shi W, et al. Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer. Sci Transl Med 2011;3(67):67ra7.

Alajez NM, Lenarduzzi M, Ito E, Hui AB, Shi W, Bruce J, et al. MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway. Cancer Res 2011;71(6):2381-91.

Alajez NM, Shi W, Hui AB, Yue S, Ng R, Lo KW, et al. Targeted depletion of BMI1 sensitizes tumor cells to P53-mediated apoptosis in response to radiation therapy. Cell Death Differ 2009;16(11):1469-79.

Alajez NM, Schmielau J, Alter MD, Cascio M, Finn OJ. Therapeutic potential of a tumor-specific, MHC-unrestricted T-cell receptor expressed on effector cells of the innate and the adaptive immune system through bone marrow transduction and immune reconstitution. Blood 2005;105(12):4583-9.

  • 2022, Qatar Biomedical Research Institute top publishing.
  • 2022, Qatar Biomedical Research Institute top external received funding.
  • 2022, among top 2% most cited scientists worldwide.
  • 2021, among top 2% most cited scientists worldwide.
  • 2021, Qatar Biomedical Research Institute highest publication award.
  • 2010, Scholar-in-Training Award, American Association of Cancer Research.
  • 2007, Excellence in Radiation Research for the 21st Century Award, Canadian Institute for Health Research.
  • 2004, Scholar-in-Training Award, American Association of cancer research.
  • 2001, DOD pre-doctoral training Award on Breast Cancer Research.
  • 1999, San Francisco State University distinguished achievement award for academic excellence.
  • 1997, Fulbright Scholarship.
Dr. Esmat Zaidan

Dr. Esmat Zaidan

Associate Professor and Associate Dean for Academic Affairs

Office location

03-C30

Dr. Esmat Zaidan

Associate Professor and Associate Dean for Academic Affairs

Educational Qualifications

PhD in Geography and Environmental Management - Planning and Development

Master in Economic Development

Entity

College of Public Policy

Biography

Dr. Esmat Zaidan is an Associate Professor at the College of Public Policy at Hamad Bin Khalifa University. She has 22 years of experience in academic institutions and international organizations like the World Bank, the Norwegian Agency for Development Cooperation (NORAD), and the United Nations Development Programme (UNDP). She has spent 13 years in academia, holding senior roles in administration, teaching, and research.

Her experience includes strategic planning, academic accreditation, and ranking, curriculum design and restructuring, the conceptualization of new academic initiatives, scientific research and evaluation, partnerships with stakeholders, as well as team leadership and capacity building. She is a strong advocate for excellence in teaching and research, teamwork and collaborative approaches, and the faculty's role in societal progress. 

Her research primarily focuses on sustainable development policy and planning with an emphasis on sustainable urbanism and the complex interaction between humans and built environments. Her research portfolio extensively covers urban resilience and sustainability policies. 

Dr. Esmat Zaidan’s approach is interdisciplinary, addressing dynamic models of socioeconomic and environmental systems to create simulations and predictive models to enhance understanding and forecasting of the complex interplays between urban and natural environments. This includes the policy pathway for energy-efficient buildings, sustainable, resilient, smart, and people-centric urban areas, as well as impacts of technological change in urban life including smart cities and net-zero carbon communities.

PhD in Geography and Environmental Management - Planning and Development

University of Waterloo, Canada

2011

Master in Economic Development

University of Waterloo, Canada

2008

Master in Urban Planning and Design

Birzeit University, Palestine

2006

  • Sustainable development strategies and policy planning
  • Human and built environment interaction
  • Urban resilience
  • climate adaptation
  • smart cities
  • and sustainability policies
  • The dynamic interplay between technology
  • human interaction
  • and policy innovation

Associate Dean for Academic Affairs

Hamad Bin Khalifa University

2024 - Present

Associate Professor

College of Public Policy, Hamad Bin Khalifa University

2024 - Present

Director of Honors Program

Qatar University

2022

Academic Coordinator

College of Arts and Sciences, Qatar University

2017 - 2021

Associate Professor in Policy, Planning, and Development

College of Arts and Sciences, Qatar University

2015 - 2022

Assistant Professor in Urban Planning and Sustainability

College of Humanities and Social Sciences, United Arab Emirates University, UAE

2013 - 2015

Assistant Professor in Urban Planning

Faculty of Arts, Birzeit University, Palestine

2011 - 2013

  • World Top 2% of Scientists as Ranked by Elsevier and Stanford University
  • 2022, Research Excellence Award, Qatar University

Jasir Jawad

Research Engineer

Jasir Jawad

Research Engineer

Educational Qualifications

MS Chemical Engineering

BE Chemical Engineering

Entity

Qatar Environment and Energy Research Institute

Biography

Jasir Jawad is a Research Engineer at Qatar Environment and Energy Research Institute (QEERI) at Haman Bin Khalifa University, Qatar. His research at QEERI is focused on the operation and supporting maintenance at the advanced MED pilot plant. He is also involved in the operation, maintenance, mathematical modeling and analysis of the Linear Fresnel Collector and Organic Rankine Cycle (LFC-ORC) pilot power plant at the QEERI outside testing facility. Moreover, he is studying advanced water vapor compression using Computational Fluid Dynamics (CFD) tools.
 
He received his MS degree in Chemical Engineering from Texas A&M University at Qatar. He earned his bachelor's in Chemical Engineering from NED University of Engineering and Technology, Pakistan. 

MS Chemical Engineering

Texas A&M University at Qatar Doha/Qatar

2018

BE Chemical Engineering

NED University of Engineering and Technology, Karachi/Pakistan

2016

  • Desalination and Water Treatment
  • Concentrating Solar Power Plant
  • Organic Rankine Cycle
  • Computational Fluid Dynamics
  • Neural Network and Mathematical Modeling
  • Process Safety

Research Engineer

Qatar Environment and Energy Research Institute (QEERI), HBKU

2021 - Present

Research Assistant

Center for Advanced Materials (CAM), Qatar University

2019 - 2021

Research Assistant

Mary Kay O'Connor Process Safety Center (MKOPSC-Qatar), TAMUQ

2017 - 2018