Intracellular protein aggregation is a feature of many late-onset neurodegenerative diseases, including Parkinson’s disease, tauopathies, and polyglutamine expansion diseases (like Huntington’s disease or HD). Many of these mutant proteins, like those causing HD, give rise to disease via toxic gain-of-function mechanisms. Therefore, the factors regulating their clearance are crucial for understanding disease pathogenesis and for developing rational therapeutic strategies.
This seminar will summarize some of CIMR’s recent work on autophagosome biogenesis and its regulation, how autophagy is compromised in certain neurodegenerative diseases, and autophagy induction as a powerful therapeutic approach for some of these conditions.
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