Dr. Issam Hmila | Hamad Bin Khalifa University
Hamad Bin Khalifa University

FACULTY BIOGRAPHIES

Dr. Issam Hmila

Dr. Issam Hmila


Postdoctoral Researcher
Neurological Disorders Research Center
Qatar Biomedical Research Institute

Biography

Dr. Issam Hmila obtained his PhD in biology from the University of Tunis El Manar in 2010. He conducted his research on nanobodies in camels at Pasteur Institute in Tunis in collaboration with Prof. Serge Muyldermans from Vrije Universiteit Brussel (Belgium). His work focused on the construction of combinatory library and phage display screening and engineering of nanobodies against the toxins of scorpions. In 2012, he secured the position of Scientist in the Pasteur Institute and worked in the laboratory of epidemiology and veterinary microbiology, where he developed new tools for the detection and diagnosis of viruses. A multiplex oligonucleotide suspension microarray (Luminex microsphere system) was developed for the rapid detection of avian respiratory viruses of major clinical importance. In addition, he developed a panel of specific ssDNA aptamers against H9N2 viruses and a sensitive method for detection of viruses, in collaboration with Prof. Srinand Srivatsan, Univresity of Minnesota, USA.


Research Interests

Dr. Hmila’s research interest lies in developing new strategies for therapy and diagnosis of different human diseases using biotechnology methods and molecular diagnostic tools.

  • His current research project is to develop novel nanobodies and aptamers to be used as tools for diagnosis and therapy of Parkinson diseases.

Selected Publications

  • A novel method for detection of H9N2 influenza viruses by an aptamer-real time-PCR. Hmila I, Wongphatcharachai M, Laamiri N, Aouini R, Marnissi B, Arbi M, Sreevatsan S, Ghram A.

    J Virol Methods. 2017

    2017
  • Accurate Detection of Avian Respiratory Viruses by Use of Multiplex PCR-Based Luminex Suspension Microarray Assay. Laamiri N, Fällgren P, Zohari S, Ben Ali J, Ghram A, Leijon M, Hmila I.

    J Clin Microbiol. 2016

    2016
  • Pre-clinical studies of toxin-specific nanobodies: evidence of in vivo efficacy to prevent fatal disturbances provoked by scorpion envenoming.

    Hmila I, Cosyns B, Tounsi H, Roosens B, Caveliers V, Abderrazek RB, Boubaker S, Muyldermans S, El Ayeb M, Bouhaouala-Zahar B, Lahoutte T. Toxicol Appl Pharmacol. 2012

    2012
  • A bispecific nanobody to provide full protection against lethal scorpion envenoming.

    Hmila I, Saerens D, Ben Abderrazek R, Vincke C, Abidi N, Benlasfar Z, Govaert J, El Ayeb M, Bouhaouala-Zahar B, Muyldermans S. FASEB J. 2010

    2010
  • VHH, bivalent domains and chimeric Heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI'.

    Hmila I, Abdallah R BA, Saerens D, Benlasfar Z, Conrath K, Ayeb ME, Muyldermans S, Bouhaouala-Zahar B. Mol Immunol. 2008

    2008