Dr. Houari Boumediene Abdesselem

Laboratory Manager

Neurological Disorders Research Center

Qatar Biomedical Research Institute

Email
Phone+974 55483125

Biography

Dr. Houari Abdesselem obtained his BSc degree in Biology from Oran 1 University (Algeria) and Paris-11 University (France). He then attained his Master’s degree in Molecular and Cellular Biology from Louis Pasteur University. In 2005, he moved to Germany for his doctoral studies where he pursued his PhD training in Neuroscience under Prof. Claudia Stuermer supervision at the University of Konstanz. His PhD work focused on the function of myelin associated proteins in vertebrate neuronal regeneration. After completing his PhD in 2009, he conducted postdoctoral trainings at Weill Cornell Medicine-New York and University of Michigan-Ann Arbor, where he investigated the role of neuronal guidance molecules in developing nervous system and neuronal cell death. In 2012, he moved to Qatar to join Weill Cornell Medicine-Qatar as a postdoc research fellow to study the function of Sirt1 protein in obesity, and adipocytes senescence. In 2016, Dr. Abdesselem was offered a position of Laboratory Manager at Qatar Biomedical Research Institute (QBRI) to manage the Neurological Disorders Research Center (NDRC), and Prof. Omar El Agnaf’s research group working on alpha-synucleinopathies and Parkinson’s disease. Dr. Abdesselem has successfully established from scratch and managed new NDRC laboratories at HBKU LAS and RDC-2 buildings. He supervised graduate students and has enormously contributed to the success of his research group. In 2019, Dr. Abdesselem has built the new Proteomics core lab facility, and transferred new proteomics technologies to QBRI, such as OLINK, SENGENICS, and SIMOA biomarker technologies. Dr. Abdesselem has proven ability to lead and manage the Proteomics core lab facility that became certified and fully operational since 2020. Besides his notable management performance, his scientific performance records are accentuated by his peer-reviewed papers published in high-impact factor journals.

Selected Publications

Al-Nesf M.A.Y*, Abdesselem HB*, Bensmail I, Ibrahim S, Saeed WAH, Mohammed SSI, Razok A, Alhussain H, Aly RMA Al Maslamani M, Ouararhni K, Khatib M.Y, Ait Hssain A, Omrani A.S, Al-Kaabi S, Al Khal A, Al-Thani A.A, Samsam W, Farooq A, Al-Suwaidi J,

Al-Maadheedh M, Al-Siddiqi H.H, Butler A.E, Decock J.V, Mohamed-Ali V and Al-Ejeh F. Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications. Nature Commun. 2022 Feb 17;13(1):946.doi: 10.1038/s41467-022-28639-4.
2022
Schmidt F*, Abdesselem HB*, Suhre K, Sohail MU, Al-Nesf M, Bensmail I, Mashod F, Sarwath H, Bernhardt J, Tan T.M, Morris P.E, Schenck E.J, Price D, Vaikath N.N, Mohamed-Ali V, Al-Maadheed M, Arredouani A, Decock J, Blackburn J.M, Choi A.M.K, and El-Agnaf

Auto-Immunoproteomics Analysis of COVID-19 ICU Patients Revealed Increased Levels of Autoantibodies Related to Male Reproductive System. 2022. https://www.biorxiv.org/content/10.1101/2022.02.09.479669v1.
2022
Hmila I, Vaikath N, Majbour NK, Erskine D, Sudhakaran IP, Gupta V, Ghanem SS, Islam Z, Emara MM, Abdesselem HB, Kolatkar PR, Achappa DK, Vinardell T, El-Agnaf OMA

Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit in-vitro seeded aggregation and toxicity. FEBS J. 2022 Jan 28. doi: 10.1111/febs.16376.
2022
Smith M*, Abdesselem HB*, Mullins M, Tan TM, Nel AJM, Al-Nesf MAY, Bensmail I, Majbour NK, Vaikath NN, Naik A, Ouararhni K, Mohamed-Ali V, Al-Maadheed M, Schell DT, Baros-Steyl SS, Anuar ND, Ismail NH, Morris PE, Mamat RNR, Rosli NSM, Anwar A, Ellan K,

K, Zain RM, Burgers WA, Mayne ES, El-Agnaf OMA, Blackburn JM. Age, Disease Severity and Ethnicity Influence Humoral Responses in a Multi-Ethnic COVID-19 Cohort. Viruses. 2021 Apr 28;13(5):786. doi: 10.3390/v13050786.
2021
Majeed Y, Halabi N, Madani AY, Engelke R, Bhagwat AM, Abdesselem H, Agha MV, Vakayil M, Courjaret R, Goswami N, Hamidane HB, Elrayess MA, Rafii A, Graumann J, Schmidt F, Mazloum NA

SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways. Sci Rep. 2021 Apr 14;11(1):8177. doi: 10.1038/s41598-021-87759-x.
2021
Madani A, Majeed Y, Abdesselem AB, Agha MV, Vakayil M, Alsukhun NK, Halabi NM, Kumar P, Hayat S, Elrayess MA, Rafii A, Suhre K and Mazloum NA

STAT3 supresses STAT1/cGAS/STING signaling pathway and inflammation in senescent preadipocytes. 2021. Antioxidants. 2021 Feb 23;10(2):334. doi: 10.3390/antiox10020334.
2021
Gupta G, Salim S, Hmila I, Vaikath N, Sudhakaran I, Ghanem S, Majbour N, Abdulla S, Emara M, Abdesselem H, Lukacsovich T, Erskine D, El-Agnaf OMA

Fibrillarform of α-synuclein-specific scFvantibody inhibits α-synucleinseeds induced aggregation and toxicity. Scientific Reports (2020). Sci Rep. 2020 May 18;10(1):8137. doi: 10.1038/s41598-020-65035-8.
2020
Fayyad M, Erskine D, Majbour NK, Vaikath NN, Ghanem S, Sudhakaran I, Abdesselem H, Lamprokostopoulou A, Vekrellis K, Morris C, El-Agnaf OMA

Investigating the presence of doubly phosphorylated α-synuclein at tyrosine 125 and serine 129 in idiopathic Lewy body diseases. Brain Pathol. 2020 Jul;30(4):831-843. doi: 10.1111/bpa.12845. Epub 2020 May 6.
2020
Fayyad M, Majbour NK, Vaikath NN, Erskine D, El-Tarawneh H, Sudhakaran IP, Abdesselem H, El-Agnaf OMA

Generation of monoclonal antibodies against phosphorylated α-Synuclein at serine 129: Research tools for synucleinopathies. (2020) Neurosci Lett. 7;725:134899. doi: 10.1016/j.neulet.2020.134899.
2020
Almuraikhy S, Kafienah W, Bashah M, Diboun I, Jaganjac M, Al-Khelaifi F, Abdesselem H, Mazloum NA, Alsayrafi M, Mohamed-Ali V, Elrayess MA

Interleukin-6 induces impairment in human subcutaneous adipogenesis in obesity-associated insulin resistance. Diabetologia. 2016 Nov;59(11):2406-16. doi: 10.1007/s00125-016-4031-3. 24.
2016
Wehner AB*, Abdesselem H*, Dickendesher TL, Imai F, Yoshida Y, Giger RJ, and Pierchala BA.

Semaphorin 3A is a retrograde cell death signal in developing sympathetic neurons. Development, 2016, doi: 10.1242/dev.134627.
2016
Abdesselem H, Madani A, Hani A, Al-Noubi M, Goswami N, Ben Hamidane H, Billing A.M, Pasquier J, Bonkovski M.S, Halabi N, Dalloul R, Sheriff M.Z, Mesaeli N, ElRayess M, Sinclair D.A, Graumann J and Mazloum N.A.

SIRT1 Limits Adipocyte Hyperplasia Through c-Myc Inhibition. Journal of Biological Chemistry (JBC), 2015, doi:10.1074/jbc. M115.675645.
2015
Pasquier J, Abu-Kaoud N, Abdesselem H, Madani A, Hoarau-Véchot J, Al. Thawadi H, Vidal F, Couderc B, Favre F & Rafii A

SDF-1alpha concentration dependent modulation of RhoA and Rac1 modifies breast cancer and stromal cells interaction. BMC Cancer. 2015 Aug 1;15:569. doi: 10.1186/s12885-015-1556-7.
2015
Pinzon-Olejua A, Welte C, Abdesselem H, Malaga-Trillo E and Stuermer C. A. O

Essential roles of zebrafish rtn4/Nogo orthologues in embryonic development. Neural Development. 2014 Apr 23;9(1):8. doi: 10.1186/1749-8104-9-8.
2014
Bonanomi D, Chivatakarn O, Bai G, Abdesselem H, Lettieri K, Marquardt T, Pierchala BA, Pfaff SL.

Ret is a multifunctional co-receptor that integrates diffusible- and contact-axon guidance signals. Cell. 2012 Feb 3;148(3):568-82.
2012
Abdesselem H, Shypitsyna A, Solis GP, Bodrikov V, Stuermer CA.

No Nogo66- and NgR-mediated inhibition of regenerating axons in the zebrafish optic nerve. Journal of Neuroscience. 2009 Dec 9;29(49):15489-98.
2009
Biryukova I, Asmar J, Abdesselem H, Heitzler P.

Drosophila mir-9a regulates wing development via fine-tuning expression of the LIM only factor, dLMO. Developmental Biology. 2009 Mar 15;327(2):487-96. Epub 2009 Jan 8.
2009

Qatar Biomedical Research Institute QBRI

FACULTY BIOGRAPHIES