Dr. Abdesselem joined QBRI in 2016 as a Laboratory Manager in Prof. Omar El-Agnaf's research group in the Neurological Disorders Research Center. His key roles are establishing and maintaining functional and operational laboratories, including management of lab equipment, procurement supply, logistics, safety and ethics, research grants, and providing technical and administrative support for researchers.
Prior to joining QBRI, Dr. Abdesselem served as a Postdoctoral researcher in Weill Cornell Medical College in Qatar (WCMC-Q) from 2012 to 2016 where he worked on fat tissue hyperplasia and obesity. He has also worked as a Postdoctoral Follow at the University of Michigan and Weill Cornell Medical College -New York, USA from 2009 to 2012, where he investigated the role of semaphorins guidance molecules in neuronal cell death and microRNA regulation of developing neurons. In 2009, Dr. Abdesselem received his Ph.D degree in Biology from University of Konstanz in Germany. Here he studied the role of Nogo, myelin inhibitory-protein in zebrafish axonal regeneration. Dr. Abdesselem received his Master degree in Cellular and Molecular Biology from Strasbourg 1 University and Bachelor degree in Cellular Biology and Physiology from Paris 11 University.
SIRT1 Limits Adipocyte Hyperplasia through c-Myc Inhibition.
Abdesselem H, Madani A, Hani A, Al-Noubi M, Goswami N, Ben Hamidane H, Billing AM, Pasquier J, Bonkowski MS, Halabi N, Dalloul R, Sheriff MZ, Mesaeli N, ElRayess M, Sinclair DA, Graumann J, Mazloum NA.
J Biological chemistry. 2016 Jan 29;291(5):2119-35. doi: 10.1074/jbc.M115.675645. Epub 2015 Dec 11.
Semaphorin 3A is a retrograde cell death signal in developing sympathetic neurons.
Wehner AB, Abdesselem H, Dickendesher TL, Imai F, Yoshida Y, Giger RJ, Pierchala BA.
Development. 2016 May 1;143(9):1560-70. doi: 10.1242/dev.134627.
Essential roles of zebrafish rtn4/Nogo paralogues in embryonic development.
Pinzón-Olejua A, Welte C, Abdesselem H, Málaga-Trillo E, Stuermer CA.
Neural Dev. 2014 Apr 23;9:8. doi: 10.1186/1749-8104-9-8.
Ret is a multifunctional coreceptor that integrates diffusible- and contact-axon guidance signals.
Bonanomi D, Chivatakarn O, Bai G, Abdesselem H, Lettieri K, Marquardt T, Pierchala BA, Pfaff SL.
Cell. 2012 Feb 3;148(3):568-82. doi: 10.1016/j.cell.2012.01.024.
No Nogo66- and NgR-mediated inhibition of regenerating axons in the zebrafish optic nerve.
Abdesselem H, Shypitsyna A, Solis GP, Bodrikov V, Stuermer CA.
J Neuroscience. 2009 Dec 9;29(49):15489-98. doi: 10.1523/JNEUROSCI.3561-09.2009.
Pasquier J, Abu-Kaoud N, Abdesselem H, Madani A, Hoarau-Véchot J, Thawadi HA, Vidal F, Couderc B, Favre G, Rafii A.
BMC Cancer. 2015 Aug 1;15:569. doi: 10.1186/s12885-015-1556-7.