Join our seminar on the shared signaling molecules between neurogenesis and brain tumorigenesis, which regulate cell proliferation, differentiation, migration, and survival.
Neural stem cells (NSCs) undergo tightly regulated processes of self-renewal and differentiation to ensure accurate cell division and production of neurons and glial cells. Abnormalities in these molecular mechanisms lead to devastating neurodevelopmental diseases and trigger neoplastic transformation and cancer stem cells. Our research shows that DIAPH3, expressed in NSCs, safeguards their division.
In the seminar, our speaker will discuss DIAPH3's role in mitotic division and how its ablation impairs neurogenesis, causes microcephaly and behavioral deficits, and accelerates glioma genesis and recurrence. Join us to deepen your understanding of the critical mechanisms underlying brain cancer and neurodevelopmental diseases and explore the potential of DIAPH3 as a therapeutic target.