FACULTY BIOGRAPHIES
Dr. Borbala Mifsud (PhD)
- Emailbmifsud@hbku.edu.qa
- Phone44547244
- Office locationB144, 1st floor, LAS building
Biography
Dr. Mifsud graduated in biology from Eotvos Lorand University in Budapest in 2006 and obtained her PhD from the Institute of Molecular Pathology in Vienna in 2010. Her work with Thomas Jenuwein involved the epigenetic characterisation of a histone methylation deficient mouse model. After her molecular biology training, she started bioinformatics in the laboratory of Professor Nicholas Luscombe at EMBL European Bioinformatics Institute (EBI) in Cambridge, and subsequently moved to UCL and the Crick Institute in London. In her postdoctoral work she focussed on developing methods for the analysis of Hi-C type data and finding new biological insights into transcriptional regulation, by applying these methods to Hi-C and capture Hi-C data sets. Dr. Mifsud joined the William Harvey Research Insitute in QMUL as an MRC eMedLab Career Development Fellow and Lecturer in 2015, where she used chromatin interaction data to understand the function of regulatory GWAS mutations. Dr. Mifsud has been an Assistant Professor at HBKU since July 2018.
Research Interests
-
Using chromatin structure information for understanding the effect of GWAS loci
-
Uncovering chromatin interactions that change during development
-
Identifying the important regulatory interactions in diseases such as leukaemia
Experience
MRC Career Development Fellow - Lecturer;
William Harvey Research Institute; Queen Mary University London, UK
2015 - 2018Postdoctoral Research Fellow
University College London and the Francis Crick Instiute, London, UK
2012 - 2015Postdoctoral Research Fellow
EBML European Bioinformatics Institute; Cambridge, UK
2010 - 2012PhD Student
Institute of Molecular Pathology, Vienna, Austria
2006 - 2010
Diploma Student
National Centre for Epidemiology, Budapest, Hungary
2004 - 2006Student researcher
Department of Plant Taxonomy, Eotvos Lorand University, Budapest, Hungary
2003 - 2004
Education
PhD
University of Vienna, Austria
2010MSc
Eotvos Lorand University, Hungary
2006
Selected Publications
-
Genetic analysis of over one million people identifies 535 novel loci for blood pressure
Nature Genetics; 2018 Sep; doi: 10.1038/s41588-018-0205-x Evangelou E.*, Warren H.R.*, Mosen-Ansorena D.*, Mifsud B.*, Pazoki R.*, He G.*, Ntritsos G.*, Dimou N.* et al
2018 -
Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system
Nature Communications; 2018 May 16;9(1):1947. Ramírez J., Duijvenboden S.V. Ntalla I., Mifsud B., Warren H.R., Tzanis E., Orini M., Tinker A., Lambiase P.D., Munroe P.B.
2018 -
GOTHiC, a probabilistic model to resolve complex biases and to identify real interactions in Hi-C data
PLoS One; 2017 Apr 5;12(4):e0174744 Mifsud B.*, Martincorena I.*, Darbo E., Sugar R., Schoenfelder S., Fraser P., Luscombe N.M.
2017 -
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Nature Genetics; 2017 Mar;49(3):403-415 Warren H.R.*, Evangelou E.*, Cabrera C.P.*, Gao H.*, Ren M*., Mifsud B.*, et al
2017 -
Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome
Nature Genetics; 2015 Oct;47(10):1179-86 Schoenfelder S.*, Sugar R.*, Dimond A.*, Javierre B-M.*, Armstrong H.*, Mifsud B., Dimitrova E., Tavares-Cadete F., Furlan-Magaril M., Jurkowski W., Segonds-Pichon A., Wingett S., Tabbada K., Andrews S., Herman B., LeProust E., Osborne C.S., Koseki H., Fraser P., Luscombe N.M., Elderkin S.
2015 -
Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C
Nature Genetics; 2015 Jun;47(6):598-606 Mifsud B.*, Tavares-Cadete F.*, Young A. N.*, Sugar R., Schoenfelder S., Ferreira L., Wingett S. , Andrews S., Grey W., Ewels P.A., Herman B., Happe S., Higgs A., LeProust E., Follows G.A., Fraser P., Luscombe N.M., Osborne C.S.
2015 -
The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements
Genome Research; 2015 Apr;25(4):582-97 Schoenfelder S.*, Furlan-Magaril M.*, Mifsud B.*, Tavares-Cadete F.*, Sugar R., Javierre B-M., Nagano T., Katsman Y., Sakthidevi M., Wingett S. W., Dimitrova E., Dimond A., Edelman L. B., Elderkin S., Tabbada K., Darbo E., Andrews S., Herman B., Higgs A., LeProust E., Osborne C.S., Mitchell J.A., Luscombe N.M., Fraser P.
2015
MYHBKU LOGIN