primary

Dr. Saif Mohammed S A Al-Kuwari

Dr. Saif Mohammed S A Al-Kuwari

Associate Professor

Office location

A 102-C, LAS Building

Dr. Saif Mohammed S A Al-Kuwari

Associate Professor

Educational Qualifications

PhD in Cryptography

PhD in Computational Forensics

Entity

College of Science and Engineering

Division

Information & Computing Technology

Biography

Dr. Saif Al-Kuwari is an associate professor at the College of Science and Engineering and director of the Qatar Center for Quantum Computing (QC2) at Hamad Bin Khalifa University. Dr. Saif Al-Kuwari graduated in computers and networks from the University of Essex and has two PhDs in Cryptography and Computational Forensics from the University of Bath and Royal Holloway, University of London

He is a fellow of IET and BCS and a senior member of IEEE and ACM. His research focuses on quantum cryptography, quantum machine learning, and quantum sensing.

 

PhD in Cryptography

University of Bath, United Kingdom

2012

PhD in Computational Forensics

Royal Holloway, University of London, United Kingdom

2012

BEng in Computers and Networks

University of Essex, United Kingdom

2006

  • Quantum computing
  • Quantum cryptography
  • Quantum machine learning
  • Quantum sensing

Associate Professor

College of Science and Engineering, Hamad Bin Khalifa University

2024 – Present

Assistant Professor

College of Science and Engineering, Hamad Bin Khalifa University

2019 – 2024

Adjunct Assistant Professor

College of Science and Engineering, Hamad Bin Khalifa University

2018 – 2019

Adjunct Research Assistant Professor

Kind Computing Research Center, Qatar University

2018 – 2021

Director

Information Technology Department, Ministry of Foreign Affairs

2013 – 2018

  • 2017; Fellow of the IET.
  • 2017; Fellow of the BCS.
  • 2016 & 2017; MESA-CISO100 Government Security Leader award, UAE.
  • 2012; The PhD platinum prize, 5th Education Excellence Day, Qatar.
  • 2007; The Graduate Platinum prize, 1st Education Excellence Day, Qatar.
Dr. Issam Hmila

Dr. Issam Hmila

Postdoctoral Researcher

Office location

RC-B2-1426

Dr. Issam Hmila

Postdoctoral Researcher

Educational Qualifications

PhD in Biology

MSc in Biochemistry

Entity

Qatar Biomedical Research Institute

Division

Neurological Disorders Research Center

Biography

Dr. Issam Hmila obtained his PhD in Biology between the Vrije Universiteit Brussel, Belgium, and the University of Tunis El Manar, Tunisia in 2010. He obtained an interuniversity diploma in advanced bioinformatics knowledge from the University-Paris Cité, France. He has also completed various courses in biostatistics, immunology, drug design, and discovery from international institutes.

His projects focus on the construction of combinatory libraries, phage display screening, and the engineering of nanobodies for immunotherapy. He was hired as an assistant professor at the Pasteur Institute in 2012, where he developed aptamers and new tools for detecting respiratory viruses of clinical importance in collaboration with the University of Minnesota, USA, and Uppsala University, Sweden. 

In 2017, he joined the Neurological Disorders Research Center at Qatar Biomedical Research Institute, where he conducted his research to develop new tools for therapy against Parkinson's and Alzheimer's diseases based on nanobodies and aptamers. His work focuses on the generation of cortical neurons from induced pluripotent stem cells and the evaluation by global transcriptomic, proteomic, and integrated omics, environmental pollutants, and new drugs with potential Alzheimer's disease modulation.

PhD in Biology

University of Tunis-El Manar, Tunisia

2010

MSc in Biochemistry

University of Tunis-El Manar, Tunisia

2004

  • Drug design and discovery
  • Nanobody and aptamer development and engineering
  • Evaluating the impact of pollutants on brain health
  • Develop diagnostic and therapeutic tools

Postdoctoral Researcher

Qatar Biomedical Research Institute, Hamad bin Khalifa University

2017 - Present

Invited Scientist

College of Veterinary Medicine, University of Minnesota, United States

2014 - 2015

Assistant Professor

Institute Pasteur of Tunis, University of Tunis-El Manar, Tunisia

2012 - 2017

Postdoctoral Researcher

Institute Pasteur of Tunis, University of Tunis-El Manar, Tunisia

2010 - 2012

Perinatal exposure to PFOS and sustained high-fat diet promote neurodevelopmental disorders via genomic reprogramming of pathways associated with neuromotor development. Hmila I, Hill J, Shalaby KE, Ouararhni K, Abedsselem H, Modaresi SMS, Bihaqi SW, Marques E, Sondhi A, Slitt AL, Zawia NH.Ecotoxicol Environ Saf. 2024 Mar 1;272:116070. doi: 10.1016/j.ecoenv.2024.116070. Epub 2024 Feb 9.

Aptamer-Assisted Proximity Ligation Assay for Sensitive Detection of Infectious Bronchitis Coronavirus. Hmila I, Marnissi B, Kamali-Moghaddam M, Ghram A.Microbiol Spectr. 2023 Feb 14;11(1):e0208122. doi: 10.1128/spectrum.02081-22. Epub 2023 Jan 18.

Inhibition of α-Synuclein Seeding-Dependent Aggregation by ssDNA Aptamers Specific to C-Terminally Truncated α-Synuclein Fibrils. Hmila I, Sudhakaran IP, Ghanem SS, Vaikath NN, Poggiolini I, Abdesselem H, El-Agnaf OMA.ACS Chem Neurosci. 2022 Dec 7;13(23):3330-3341. doi: 10.1021/acschemneuro.2c00362. Epub 2022 Nov 8.

Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit in-vitro seeded aggregation and toxicity. Hmila I, Vaikath NN, Majbour NK, Erskine D, Sudhakaran IP, Gupta V, Ghanem SS, Islam Z, Emara MM, Abdesselem HB, Kolatkar PR, Achappa DK, Vinardell T, El-Agnaf OMA.FEBS J. 2022 Aug;289(15):4657-4673. doi: 10.1111/febs.16376. Epub 2022 Feb 25.

A bispecific nanobody to provide full protection against lethal scorpion envenoming. Hmila I, Saerens D, Ben Abderrazek R, Vincke C, Abidi N, Benlasfar Z, Govaert J, El Ayeb M, Bouhaouala-Zahar B, Muyldermans S.FASEB J. 2010 Sep;24(9):3479-89. doi: 10.1096/fj.09-148213. Epub 2010 Apr 21.

  • First place in 2023 QBRI/HBKU research in Focus Day.
  • Intern collaborative project, by Institute Pasteur of Tunis (Tunisia).
  • 2013 early career MENA scientists research grant project (USA).
Dr. Vijay Gupta

Dr. Vijay Gupta

Postdoctoral Researcher

Dr. Vijay Gupta

Postdoctoral Researcher

Entity

Qatar Biomedical Research Institute

Division

Neurological Disorders Research Center

Biography

Dr. Vijay Gupta received his Master’s degree in Microbiology from CCS University, Meerut, India and Ph.D. at the Centre for Cellular and Molecular Biology (CCMB), Hyderabad, INDIA (2006). Dr. Gupta was awarded ASCB pre-doctoral travel award to attend ASCB annual meeting in 2005, Carl Storm International Diversity Fellowship to attend the Gordon Research Conference in University of New England, Maine, USA 2006 and later on Royal Society International Incoming Fellowship (2006) from the Royal Society, London, UK to perform research at The University of Bristol where he worked for fifteen months with the honorary title of Royal Society International Research fellow. He joined The Scripps Research Institute, La Jolla, USA on Target Characterization Fellowship funded by Cystic Fibrosis Foundation, USA as CF fellow for five years and then moved to University of California, San Diego as Assistant Project Scientist where he worked till June, 2017.

Dr. Gupta has multidisciplinary research experience in the fields of protein trafficking, cancer and human genetic diseases and has published more than fifteen publications including top-tier journals such as Nature Chemical biology, Developmental Cell, PNAS, JCS and Traffic. He is an invited member of Sigma Xi- Scientific Honor Society, elected 2013, invited member of Cell Stress Society International (CSSI), USA, peer review board member of JoVe and Dove press and has reviewed more than thirty manuscripts. One of the hobbies of Dr. Gupta is popular science writing for the general public, aimed at raising scientific awareness.

 

Common neurodegenerative diseases such as Parkinson’s Disease, Dementia with Lewy Bodies (DLB) and Multiple System Atrophy (MSA) are characterized by progressive deposition of α-synuclein (α-syn) protein within inclusions referred to as Lewy bodies and glial cytoplasmic inclusions respectively. Amongst the various approaches attempting to tackle the pathological features of synucleinopathies, immunotherapy holds much promise. α-Syn antibodies could potentially block processes leading to the pathogenesis of such neurodegenerative diseases. The limitation of such antibodies is their inefficiency in crossing the Blood-Brain Barrier (BBB). Dr. Gupta’s research interests lies in designing a variety of strategies to develop efficient antibodies or similar molecules with superior BBB cross over capacities.

  • The aim of the current research project focuses on using a fusion protein engineered to include the FAb region of existing α-Syn antibodies. This single-chain-fragment-variable is designed to have increased BBB penetration by virtue of its smaller size and its conjugation with a carrier. It is envisaged that with enhanced penetration there will be superior brain targeting results compared to conventional α-syn antibodies.

Farquhar and Pradipta Ghosh. “GIV/Girdin activates Gαi and inhibits Gαs via the same motif”. PNAS. 2016 Sep 27;113(39):E5721-30.

Farquhar and Pradipta Ghosh, “CDK5 Activates Guanine Nucleotide Exchange Factor GIV/Girdin to Orchestrate Migration-Proliferation Dichotomy”. PNAS, 2015 Sep 1;112:E4874-83.

Farquhar,* and Pradipta Ghosh * “Activation of Gi at the Golgi by GIV/Girdin Imposes Finiteness in Arf1 Signaling”. Dev. Cell 33, 1–15, April 20, 2015.

J Proteome Res. 2014 13 (11), PP 4668-4675.

2013 Jan; 9(1):12-4.

“Kinesin-1 (uKHC/KIF5B) is required for bidirectional motility of ER exit sites and efficient ER-to-Golgi transport” Traffic, Volume 9, Issue 11 , Pages 1850-66, (2008).

Pubmed link

Dr. Zeyaul Islam

Dr. Zeyaul Islam

Postdoctoral Researcher

Dr. Zeyaul Islam

Postdoctoral Researcher

Entity

Qatar Biomedical Research Institute

Division

Diabetes Research Center

Biography

Dr. Zeyaul Islam completed his Master’s (2006) from Aligarh Muslim University (AMU) India, and worked on protein folding problem where he exploited biophysical techniques to understand the stages/intermediates during protein folding. On completion, he joined the protein crystallography lab under the supervision of Dr. Subramanian Karthikeyan at the Institute of Microbial Technology for his doctrate. During this period he worked on understanding the structure-function relationship of the enzymes of Riboflavin/FAD biosynthesis pathway from Vibrio cholerae and used it as a template for structure-based drug designing for the development of specific drugs (completed in 2012). As a postdoctoral researcher he had the opportunity to combine his MSc and PhD experiences; he worked on molecular chaperones (proteins that assist in protein folding) in IISER, Bhopal, India. He has worked on various aspect of co-chaperone Hsp40s and their cellular role in Hsp70/Hsp40 network using protein biochemistry and structural biology approaches.

Dr. Islam secured the FAPESP postdoctoral fellowship in 2015 and worked with Dr. Andre LB Ambrosio, LNBio, CNPEM, Brazil. His project was titled, “Biophysical and biochemical studies of the human glutaminases (important in cancer metabolism) in complex with novel binding partners”. He also explored supratetrameic form (filamentous) of glutaminases by cryo-electron microscopy (cryo-EM). He was also involved in human membrane protein characterization especially mitochondrial pyruvate carriers. He joined QBRI as a Postdoctoral Researcher in March, 2018.

 

Structural basis for competitive inhibition of 3,4-dihydroxy-2-butanone-4-phosphate synthase from Vibrio cholerae. J Biol Chem. 2015; 290(18):11293-308.

The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats. J Biol Chem. 2017; 292(27):11572-11585. (* Co-author).

New paradigm in ankyrin repeats: Beyond protein-protein interaction module. Int J Biol Macromol. 2018; 109:1164-1173.

Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter. Sci Rep. 2018; 8(1):3510.

N-terminal phosphorylation of glutaminase C decreases its enzymatic activity and cancer cell migration. Biochimie. 2018; 154:69-76.

Emerging Targets and Latest Proteomics Based Therapeutic Approaches in Neurodegenerative Diseases. Curr Protein Pept Sci. 2018; 19(9):858-875.

Dr. Olfa Khalifa

Dr. Olfa Khalifa

Postdoctoral Researcher

Dr. Olfa Khalifa

Postdoctoral Researcher

Entity

Qatar Biomedical Research Institute

Division

Diabetes Research Center

Biography

Dr. Olfa Khalifa obtained her Master’s degree in Biology of Vascular Diseases from the faculty of Pharmacy of Montasir in Tunisia, in 2012 and a PhD in Genetics and Immunology from the University of Montpellier in France in 2016. As part of her work towards her doctorate, Dr. Khalifa investigated the role of new genes in rheumatoid arthritis. She is skilled in many molecular and cellular biology techniques including real time PCR, sanger sequencing, miRNA profiling, ACS, ELISA, cell culture, microarray, and other basic molecular biology techniques. Her Ph.D. work has been published in peer-reviewed international journals.

Dr. Khalifa joined QBRI in 2018 and is currently working with Dr. Arredouani. She is working on a project that investigates the molecular mechanisms that underlie the positive effect of GLP-1 agonist on non-alchoholic fatty liver disease.

 

 

Dr. Abdoulaye Diané

Dr. Abdoulaye Diané

Postdoctoral Researcher

Dr. Abdoulaye Diané

Postdoctoral Researcher

Entity

Qatar Biomedical Research Institute

Division

Diabetes Research Center

Biography

Dr. Diane received his Master’s degree in Nutrition and Dietetics from Université Cheikh Anta Diop de Dakar, Senegal. He completed his PhD in Human Nutrition at AgroParisTech Institute, Paris (France). After completion of his doctoral degree in 2006, Dr. Diané was awarded a Postdoctoral Research Training Fellowship in Obesity/Healthy Body Weight Program from CIHR with an opportunity to work at the the Lipid Research Centre at Laval University in Quebec, Canada; here he worked on cardiovascular complications of diabetes from 2007-2008.

In November 2008, he joined the Metabolic and Cardiovascular Diseases Laboratory at the University of Alberta, Edmonton, Canada as a Postdoctoral Researcher/Research Associate & Teaching Assistant for 8 years. He worked on many research projects investigating the impact of nutrition and pharmacotherapies on cardiometabolic risk in animal models of Polycystic Ovary Syndrome, metabolic syndrome, diabetes and cardiovascular diseases.

In 2014, he briefly joined (9 months) the Northern Medical Program, University of Northern British Columbia, Canada as a Postdoctoral Research Associate investigating the physiological and molecular mechanisms of the Pituitary Adenylate Cylase-Activating Polypeptide (PACAP) involved in adaptive thermogenesis.

In August 2017, he joined Dr. Dehbi’s group as a Postdoctoral Researcher in the Diabetes Research Center of QBRI working on many projects related to the role of heat shock proteins, in the pathophysiology of insulin resistance and type 2 diabetes.

Dr. Diané has extensive experience in pre-clinical animal models of chronic metabolic diseases. He will help in the setup of functional vivarium at QBRI, developing animal models of metabolic diseases.

 

Differential effects on intestinal adaptation following exogenous glucagon-like peptide-2 therapy with and without enteral nutrition in neonatal short bowel syndrome. J. Parenter Enteral Nutr. 2017 Sep 22. pii: 0148607116665812.

Insights From The JCR:La-Cp Corpulent Rat Strain. Frontiers in Nutrition (section Clinical Nutrition); Oct. 2016 doi: 10.3389/fnut.2016.00044

Hypolipidemic and cardioprotective benefits of native Canadian hawthorn extract in the JCR:LA- cp rodent model of dyslipidemia and cardiac dysfunction. Food & Function. 2016, DOI: 10.1039/c6fo01023g.

Beef fat enriched with polyunsaturated fatty acid biohydrogenation products improves insulin sensitivity without altering dyslipidemia in insulin resistant JCR:LA-cp rats. Lipids 2016, DOI: 10.1007/s11745-016-4148-7.

PACAP is essential for the Adaptive Thermogenic Response of Brown Adipose Tissue to Cold Exposure. J Endocrinol. 2014; 222:327-39. PMID: 25056115.

For more publications: https://www.ncbi.nlm.nih.gov/pubmed/?term=Diane+Abdoulaye

Dr. Mariam Al-Muftah

Dr. Mariam Al-Muftah

Scientist

Joint Assistant Professor

Dr. Mariam Al-Muftah

Scientist

Joint Assistant Professor

Entity

Qatar Biomedical Research Institute

College of Health and Life Sciences

Division

Translational Oncology Research Center

Biography

Dr. Mariam Al-Muftah received her BSc in Medical Genetics (Honors) from the University of Wales in the United Kingdom in 2005 and pursued her post graduated education to complete a Master of Research (MRes) in Biological Sciences in 2007 and a PhD of Medicine (cancer immunotherapy) as a joint project between the Cancer Research UK Manchester Institute and the University of Manchester in the United Kingdom. Her PhD project was focused on the use of a fully autologous mouse model to study immune regulation towards 5T4 targeted immunotherapies. Furthermore, she focused on the generation of novel chimeric antigen receptors against the tumor associated antigen 5T4.

After completing her doctoral degree in 2011, she became a lecturer of Biology at Qatar University and was later promoted to the rank of Assistant Professor. In February 2012, she was seconded to Qatar Biomedical Research Institute as a scientist to pursue her research interest. Recently, she completed an executive master program in Strategic Business Unit Management from HEC Paris University in Qatar. Dr. Mariam has taught several courses in general biology and molecular biology at the department of Biological and Environmental Sciences.

 

Dr. Al-Muftah research focuses on the exploitation of immune cells as therapeutic agents to target and eradicate cancer, particularly to design and arm T-lymphocytes with chimeric antigen receptors to specifically target a tumor associated antigen. Furthermore, she is interested in understanding how endogenous expression of the target antigen impacts the efficacy of this type of immunotherapy, particularly the effect of immunosuppressive cells (T-regulatory cells and MDSCs) and cytokines upon cancer therapy, with the aim of mimicking what really happens in patients.

Dr Al-Muftah is also interested and involved other projects focusing on the identification of specific cancer biomarkers, particularly microRNAs, long non coding RNAs and cancer testis antigens with the aim of elucidating the complexity of cancer pathogenesis and identifying potential candidates for cancer immunotherapy.

  • Elucidating the mechanisms modulating triple negative breast cancer aggressiveness by dissecting intertumoral and intratumoral heterogeneity at the cellular and molecular levels
  • including immunophenotyping of the tumor microenvironment and identifying potential targets for the design of cancer immunotherapies.
  • The role of cancer testis antigens in triple negative breast cancer and their potential as effective targets for T-cell based immunotherapy (a collaborative project with Dr. Julie Decock)
  • Dr. Al-Muftah is also leading a project in collaboration with Dr. Lotfi Chouchane and Dr. Konduru Sastry from Weil Cornel Medical College in Qatar to understand the molecular mechanisms underlying the development of prostate cancer into the castration-resistant state
  • with the aim of identify key pro- and anti-apoptotic molecules and microRNAs that render prostate cancer cells at advanced stage resistant to therapy.
  • Collaborator Name: Dr. Lotfi Chouchane Institute : WCM-Q Research Area : Prostate Cancer
  • Collaborator Name: Dr. Konduru Sastry Institute : WCM-Q/SMRC Research Area : Prostate/Breast Cancer
  • Collaborator Name: Dr. Julie Decock Institute : QBRI Research Area : Breast Cancer
  • Collaborator Name: Dr. Said Dermime Institute : NCCCR - HMC Research Area : Cancer
  • Collaborator Name: Dr. Nader AL-Dewik Institute : HMC Research Area : Hematological malignancies
  • Collaborator Name: Dr. Shahinaz Bedri Institute : WCMCQ Research Area : Breast Cancer

MENTORING

Name: Summer Student Program (BSc level) Institution : Qatar University/Carnegie Mellon University in Qatar Period : May 2016 – July 2016

MENTORING

Name: PhD Student Institution : Hamad Bin Khalifa University Period : 2016-

Dr. Nehad Alajez

Dr. Nehad Alajez

Principal Investigator

Joint Professor

Dr. Nehad Alajez

Principal Investigator

Joint Professor

Educational Qualifications

PhD

MSc

Entity

Qatar Biomedical Research Institute

College of Health and Life Sciences

Division

Translational Oncology Research Center

Biography

Dr. Nehad Alajez earned his PhD in tumour immunology from the University of Pittsburgh School of Medicine in USA, and subsequently completed his post-doctoral training at the Princess Margaret Cancer Center (University Health Network), a premier cancer research institute in Canada. His main research interest is to investigate the role of the Polycomb gene family and non-coding microRNAs in driving cancer progression and their potential utilization for targeted therapies. Dr. Alajez is a recipient of several prestigious awards and has published more than 100 articles in top-tier ISI-indexed journals including Blood, Cancer Research, Cell Death and Differentiation, Cell Death and Disease, Signal Transduction and Targeted Therapy, Molecular Therapy (family journals), EMBO Molecular Medicine, and in Science Translational Medicine. Dr. Alajez currently has close to 5000 citations and an h-index of 35 and i10-index of 74.

Prior to his current appointment, Dr. Alajez was appointed as the Associate Professor at King Saud University College of Medicine, Kingdom of Saudi Arabia. Dr. Alajez’s main research interests are focused on ‘translational oncology research’ with main emphasis on novel biomarker discovery and targeted therapeutics for breast cancers. In particular, Dr. Alajez’s team is studying noncoding RNAs (micoRNAs and lncRNAs) as disease and predictive biomarkers for patients’ response to therapy. Dr. Alajez has strong expertise in transcriptome analysis, noncoding RNAs, and biomarker discovery field and is currently ranked among the top 2% most cited scientist globally. He is a recipient of several major grants, including funding from Qatar National Research Fund, in addition to his editorial roles on several journals.

 

PhD

University of Pittsburgh, USA

2003

MSc

San Francisco State University, USA

1999

BSc

Islamic University of Gaza, Palestine

1995

Dr. Alajez main research interests are focused on precision medicine aiming at the discovery of novel tumour and circulating biomarkers for breast cancer diagnosis, prognosis, and therapy. Additionally, Dr. Alajez’s group is conducting CRISPR-Cas9 genomic screens to elucidate the role of miRNAs and lncRNAs in driving breast cancer survival and resistance to standard therapies.

  • Identification of molecular signatures predictive of pathological complete response to neoadjuvant therapy in breast cancer.
  • Identification of circulating miRNAs as diagnostic and predictive biomarkers for breast cancer.
  • Transcriptomic profiling of breast cancer for diagnostic
  • prognostic
  • and therapeutic applications.
  • CRISPR-Cas9 genomic screen to identify novel therapeutic vulnerabilities in breast cancer.

Principal Investigator

Translational Oncology Research Center, Qatar Biomedical Research Institute

2022 - Present

Senior Scientist

Translational Cancer and Immunity Center, Qatar Biomedical Research Institute

2018 - 2022

Associate Professor

College of Medicine, King Saud University

2015 - 2018

Assistant Professor

College of Medicine, King Saud University

2011 - 2015

Vishnubalaji R, Shaath H, Al-Alwan M, Abdelalim EM, Alajez NM. Reciprocal interplays between MicroRNAs and pluripotency transcription factors in dictating stemness features in human cancers. Semin Cancer Biol 2022;87:1-16.

Vishnubalaji R, Abdel-Razeq H, Gehani S, Albagha OME, Alajez NM. Identification of a Gene Panel Predictive of Triple-Negative Breast Cancer Response to Neoadjuvant Chemotherapy Employing Transcriptomic and Functional Validation. Int J Mol Sci 2022;23(18).

Shaath H, Vishnubalaji R, Elango R, Kardousha A, Islam Z, Qureshi R, et al. Long non-coding RNA and RNA-binding protein interactions in cancer: Experimental and machine learning approaches. Semin Cancer Biol 2022;86(Pt 3):325-45.

Vishnubalaji R, Alajez NM. Transcriptional landscape associated with TNBC resistance to neoadjuvant chemotherapy revealed by single-cell RNA-seq. Mol Ther Oncolytics 2021;23:151-62.

Shaath H, Vishnubalaji R, Elango R, Khattak S, Alajez NM. Single-cell long noncoding RNA (lncRNA) transcriptome implicates MALAT1 in triple-negative breast cancer (TNBC) resistance to neoadjuvant chemotherapy. Cell Death Discov 2021;7(1):23.

Elango R, Vishnubalaji R, Shaath H, Alajez NM. Molecular subtyping and functional validation of TTK, TPX2, UBE2C, and LRP8 in sensitivity of TNBC to paclitaxel. Mol Ther Methods Clin Dev 2021;20:601-14.

Alajez NM. COVID-19: complexity of disease severity revealed by systemic and localized single cell immune atlas. Signal Transduct Target Ther 2021;6(1):156.

Vishnubalaji R, Shaath H, Elango R, Alajez NM. Noncoding RNAs as potential mediators of resistance to cancer immunotherapy. Semin Cancer Biol 2020;65:65-79.

Shaath H, Vishnubalaji R, Elkord E, Alajez NM. Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19. Cells 2020;9(11).

Sasidharan Nair V, Toor SM, Taouk G, Pfister G, Ouararhni K, Alajez NM, et al. Pembrolizumab Interferes with the Differentiation of Human FOXP3(+)-Induced T Regulatory Cells, but Not with FOXP3 Stability, through Activation of mTOR. J Immunol 2020;204(1):199-211.

Hanieh H, Ahmed EA, Vishnubalaji R, Alajez NM. SOX4: Epigenetic regulation and role in tumorigenesis. Semin Cancer Biol 2020;67(Pt 1):91-104.

Elango R, Alsaleh KA, Vishnubalaji R, Manikandan M, Ali AM, Abd El-Aziz N, et al. MicroRNA Expression Profiling on Paired Primary and Lymph Node Metastatic Breast Cancer Revealed Distinct microRNA Profile Associated With LNM. Front Oncol 2020;10:756.

Vishnubalaji R, Shaath H, Elkord E, Alajez NM. Long non-coding RNA (lncRNA) transcriptional landscape in breast cancer identifies LINC01614 as non-favorable prognostic biomarker regulated by TGFbeta and focal adhesion kinase (FAK) signaling. Cell Death Discov 2019;5:109

Vishnubalaji R, Elango R, Al-Toub M, Manikandan M, Al-Rikabi A, Harkness L, et al. Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B. Sci Rep 2019;9(1):8101

Elango R, Vishnubalaji R, Manikandan M, Binhamdan SI, Siyal AA, Alshawakir YA, et al. Concurrent targeting of BMI1 and CDK4/6 abrogates tumor growth in vitro and in vivo. Sci Rep 2019;9(1):13696

Hamam R, Hamam D, Alsaleh KA, Kassem M, Zaher W, Alfayez M, et al. Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers. Cell Death Dis 2017;8(9):e3045

Vishnubalaji R, Hamam R, Yue S, Al-Obeed O, Kassem M, Liu FF, et al. MicroRNA-320 suppresses colorectal cancer by targeting SOX4, FOXM1, and FOXQ1. Oncotarget 2016;7(24):35789-802.

Hamam R, Ali AM, Alsaleh KA, Kassem M, Alfayez M, Aldahmash A, et al. microRNA expression profiling on individual breast cancer patients identifies novel panel of circulating microRNA for early detection. Sci Rep 2016;6:25997.

Vishnubalaji R, Hamam R, Abdulla MH, Mohammed MA, Kassem M, Al-Obeed O, et al. Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer. Cell Death Dis 2015;6(1):e1614.

Ito E, Yue S, Moriyama EH, Hui AB, Kim I, Shi W, et al. Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer. Sci Transl Med 2011;3(67):67ra7.

Alajez NM, Lenarduzzi M, Ito E, Hui AB, Shi W, Bruce J, et al. MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway. Cancer Res 2011;71(6):2381-91.

Alajez NM, Shi W, Hui AB, Yue S, Ng R, Lo KW, et al. Targeted depletion of BMI1 sensitizes tumor cells to P53-mediated apoptosis in response to radiation therapy. Cell Death Differ 2009;16(11):1469-79.

Alajez NM, Schmielau J, Alter MD, Cascio M, Finn OJ. Therapeutic potential of a tumor-specific, MHC-unrestricted T-cell receptor expressed on effector cells of the innate and the adaptive immune system through bone marrow transduction and immune reconstitution. Blood 2005;105(12):4583-9.

  • 2022, Qatar Biomedical Research Institute top publishing.
  • 2022, Qatar Biomedical Research Institute top external received funding.
  • 2022, among top 2% most cited scientists worldwide.
  • 2021, among top 2% most cited scientists worldwide.
  • 2021, Qatar Biomedical Research Institute highest publication award.
  • 2010, Scholar-in-Training Award, American Association of Cancer Research.
  • 2007, Excellence in Radiation Research for the 21st Century Award, Canadian Institute for Health Research.
  • 2004, Scholar-in-Training Award, American Association of cancer research.
  • 2001, DOD pre-doctoral training Award on Breast Cancer Research.
  • 1999, San Francisco State University distinguished achievement award for academic excellence.
  • 1997, Fulbright Scholarship.
Dr. Prasanna R Kolatkar

Dr. Prasanna R Kolatkar

Senior Scientist

Dr. Prasanna R Kolatkar

Senior Scientist

Educational Qualifications

PhD in Chemistry

BA in Biology

Entity

Qatar Biomedical Research Institute

Division

Diabetes Research Center

Biography

Dr. Prasanna R Kolatkar graduated in structural biology from the University of Texas at Austin in 1991. He has worked in the Michael Rossmann laboratory at Purdue University focusing on virus-receptor relationships. Dr. Kolatkar was also awarded the Jane Coffin Childs Memorial Fund fellowship by Purdue University. He has experience working at the Bioinformatics Center, Institute of Molecular and Cell Biology, and Genome Institute of Singapore.

Dr. Kolatkar's current research involves understanding the molecular details of transcription factor (TF) complexes associated with stem cell biology with pancreatic development. His laboratory employs biochemistry and structural biology to discover how TFs generate function through combinatorial interactions.

 

PhD in Chemistry

University of Texas at Austin, United States

1991

BA in Biology

Augustana College, Rock Island, IL, United States

1985

BA in Chemistry

Augustana College, Rock Island, IL, United States

1985

  • Mechanistic analysis of transcription factor networks
  • TFs in pluripotency and their combinatorial code
  • TFs in diabetes pathways
  • X-ray crystallography

Senior Scientist

Qatar Biomedical Research Institute, Hamad Bin Khalifa University

2013 - Present

Group Leader

Laboratory for Structural Biology, Genome Institute of Singapore, Singapore

2001 - 2013

Adjunct Associate Professor

Department of Biological Sciences, National University of Singapore, Singapore

2001 - 2013

Adjunct Associate Professor

Department of Computer Engineering, Nanyang Technological University, Singapore

2001 - 2013

Principal Investigator

Bioinformatics Centre, Institute of Molecular and Cell Biology, Singapore

2000 - 2001

  • 2015; Thanaa Award for Professional Excellence, QBRI/QF
  • 1999; Outstanding University Research Award, NUS
  • 1992-1995; Jane Coffin Childs Memorial Fund for Medical Research (Post-doc)
  • 1991; EAKIN Award for Research Excellence (Graduate Research) UT Austin
Dr. Omar El Agnaf

Dr. Omar El Agnaf

Principal Investigator

Joint Professor

Dr. Omar El Agnaf

Principal Investigator

Joint Professor

Entity

Qatar Biomedical Research Institute

College of Health and Life Sciences

Division

Neurological Disorders Research Center

Biography

Dr. Omar El-Agnaf is considered a pioneer in the field of Parkinson’s and related neurodegenerative diseases. He was awarded his Doctor of Philosophy (PhD) in Biochemistry in 1997 at Queen’s University Belfast, UK. Between 1997 to 1999, he worked as a postdoctoral scientist at the School of Biology and Biochemistry, Queen’s University Belfast. Following this, Dr. El-Agnaf undertook an additional two-year post-doctoral position at St. George’s Medical School in London. In 2001, he was awarded a Research Fellowship from the Parkinson’s Disease Society-UK to establish his research group at Lancaster University. After completing his Research Fellowship in 2004, Dr. El-Agnaf joined the College of Medicine at UAE University and was appointed to the Biochemistry Department. In September 2014, he joined Hamad Bin Khalifa University (HBKU) at Qatar Foundation (QF), and in 2016 he was appointed Acting Executive Director of Qatar Biomedical Research Institute (QBRI), part of HBKU, and became the Executive Director (2018 - 2022).

Dr. El-Agnaf has successfully directed QBRI’s efforts towards translational research to improve and transform healthcare through innovations in the prevention, diagnosis, and treatment of diseases affecting Qatar and the region. Under his leadership, QBRI has realized significant achievements. This has included securing extramural research funding to establish robust alliances with biotechnology and pharmaceutical companies to winning the 2017 Arab Best Research Institution of the Year Award.

Since his move to the region in 2004, Dr. El-Agnaf has assembled an excellent research team that has positioned itself at the forefront of neuroscience research internationally, building a reputable portfolio in the Middle East and beyond, and has been successful in attracting an array of scientific funding from prestigious international funding agencies. Individually, his discoveries have greatly impacted the scientific research community, provided further insight into the molecular pathogenesis of Parkinson’s disease, and offered new opportunities for the development of novel diagnostic and therapeutic tools for the disease. 

Dr. El-Agnaf is frequently invited as a speaker at international scientific and clinical meetings and is currently a member of the editorial boards of several international journals. Publications in high-ranking scientific journals validate Dr. El-Agnaf's track record of superior basic and translational research productivity. He has published nearly 137 refereed articles, with citations exceeding 13,350 (to date), and possesses an h-index of 61.

 

  • Identifying Potential Molecular Biomarkers for Autism Spectrum Disorder
  • Identifying Novel Biomarkers for Type-2 Diabetes- associated Complications and Comorbidities
  • Development of Novel Diagnostic and Therapeutic Tools for Parkinson's Diseases and Related Disorders
  • Engineering Antibodies for Diagnostic and Therapeutic Approaches
  • Non-viral Mediated Delivery of CRISPR/Cpf1 to the Central Nervous System for Efficient Non-Homologous Gene Correction in Neuronal Cells

As part of Dr. El-Agnaf’s academic tenure (Mentoring)

He has supervised numerous graduate and PhD students.

2001 to 2018

Teaching, HBKU, Postgraduate Course (Professor)

Advanced Biochemistry

Teaching, HBKU, Postgraduate Course (Professor)

Molecular and Cellular Biology of Neurodegenerative diseases.

Teaching, HBKU, Postgraduate Course (Professor)

Advanced Techniques in Biochemistry and Molecular Biology

Selected Patents

Selected Publications

Complex I reductions in the nucleus basalis of Meynert in Lewy body dementia: the role of Lewy bodies. Acta Neuropathol Commun. 8(1):103. doi: 10.1186/s40478-020-00985-8.

CSF Biomarkers Reflecting Protein Pathology and Axonal Degeneration Are Associated with Memory, Attentional, and Executive Functioning in Early-Stage Parkinson's Disease. Int J Mol Sci. 21(22):8519. doi: 10.3390/ijms21228519.

Expression, purification and characterization of α-synuclein fibrillar specific scFv from inclusion bodies. PLoS One;15(11):e0241773. doi: 10.1371/journal.pone.0241773.

Safety and immunogenicity of the α-synuclein active immunotherapeutic PD01A in patients with Parkinson's disease: a randomised, single-blinded, phase 1 trial. Lancet Neurol. 19(7):591-600. doi: 10.1016/S1474-4422(20)30136-8.

Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity. Sci Rep. 10(1):8137. doi: 10.1038/s41598-020-65035-8.

M. Goillandeau, C. Perier, C. Estrada, N. Garcia-Carrillo, A. Recasens, N.N. Vaikath, O.M.A. El-Agnaf, M.T. Herrero, P. Derkinderen, M. Vila, J.A. Obeso, B. Dehay, E. Bezard (2020). Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates. Sci Adv. 6(20):eaaz9165. doi: 10.1126/sciadv.aaz9165.

Investigating the presence of doubly phosphorylated α-synuclein at tyrosine 125 and serine 129 in idiopathic Lewy body diseases. Brain Pathol. 2020 Jul;30(4):831-843. doi: 10.1111/bpa.12845.

P. Derkinderen, B. Dehay, E. Bezard (2020). Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates. Brain.143(5):1462-1475. doi: 10.1093/brain/awaa096.

CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson's disease: a study in LRRK2 mutation carriers. Transl Neurodegener. 9(1):15. doi: 10.1186/s40035-020-00192-4.

CSF or serum neurofilament light added to α-Synuclein panel discriminates Parkinson's from controls. Mov Disord. 35(2):288-295. doi: 10.1002/mds.27897.

α-Synuclein BAC transgenic mice exhibit RBD like behaviour and hyposmia: a prodromal Parkinson's disease model. Brain;143(1):249-265. doi: 10.1093/brain/awz380.

Lewy Body Pathology Is More Prevalent in Older Individuals With Mitochondrial Disease Than Controls. Acta Neuropathol. 139(1):219-221.

Towards Acoustic Radiation Free Lamb Wave Resonators for High-resolution Gravimetric Biosensing. IEEE Sensors Journal, (In press).

Generation of monoclonal antibodies against phosphorylated α-Synuclein at serine 129: Research tools for synucleinopathies. Neurosci Lett. 7;725:134899. doi: 10.1016/j.neulet.2020.134899.

Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts. BMC Complement Med Ther. 6;20(1):73. doi: 10.1186/s12906-020-2849-1.

  • 2020 – 2024. NPRP Program (QNRF, Qatar): Corneal Confocal Microscopy A rapid diagnostic and prognostic imaging biomarker for neurodegeneration in dementia. Co- Principal Investigator
  • 2019 – 2024. Cluster Program (QNRF, Qatar): Qatar Diabetes Prevention Program (QDPP). Co- Principal Investigator
  • 2019 – 2022. Interdisciplinary Research Program (QBRI, HBKU): Identifying Potential Biomarkers for Autism Spectrum Disorder. Principal Investigator
  • 2019 – 2022. Interdisciplinary Research Program (QBRI, HBKU): Identifying Biomarkers for Diabetes Complications. Principal Investigator
  • 2016 – 2019: PNRP-QNRF (Doha, Qatar) > Development of Novel Diagnostic and Therapeutic Tools for Parkinson's Diseases and Related Disorders.  Principal Investigator
  • 2016 – 2019: Lundbeck A/S (Copenhagen, Denmark) > Development of antibody-based assays for detection of alpha-synuclein species in human CSF and plasma.  Co-Investigator
  • 2015 – 2018: PNRP-QNRF (Doha, Qatar) > Application of conformation-specific antibodies to biomarker development for Parkinson’s disease.  Principal Investigator
  • 2016-2018: Micheal J Fox Foundation for Parkinson’s Research (NY, USA). > Pre-analytical extracellular esicle enrichment for increased reliability for alpha-synuclein detection in plasma and CSF.  Co-investigator.
  • Micheal J Fox Foundation for Parkinson’s Research (NY, USA) > Validation of CSF alpha-synuclein species as surrogate biomarkers for Parkinson’s disease.  Principal Investigator