Dr. Essam Abdelalim | Hamad Bin Khalifa University

Qatar Biomedical Research Institute QBRI

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Hamad Bin Khalifa University

FACULTY BIOGRAPHIES

Dr. Essam Abdelalim

Dr. Essam Abdelalim

Scientist
Diabetes Research Center
Qatar Biomedical Research Institute
Joint Assistant Professor
College of Health and Life Sciences
  • Phone+974 44546432
  • Office locationB2-1463, HBKU Research Complex, North Building

Biography

Dr. Essam M. Abdelalim is a scientist at the Qatar Biomedical Research Institute (QBRI) and an assistant professor at the College of Science and Engineering (CSE) and the College of Health and Life Sciences (CHLS). He received his PhD in Medical Science from Shiga University of Medical Science, Japan. At CHLS, Dr. Abdelalim is coordinating the “Stem Cell Biology” course and also teaches several courses, and supervises several masters and PhD students. Since April 2014, Dr. Abdelalim has been leading the diabetes stem cell research at QBRI. 

He has been awarded multiple NPRP grants and QBRI Internal Research grants to study diabetes and pancreatic beta-cell differentiation. He has established strong collaborations in the field of diabetes with key scientists and clinicians from different institutions inside Qatar, including Hamad Medical Corporation (HMC), Sidra Medicine, Weill Cornell Medicine-Qatar (WCM-Q), and Carnegie Mellon University in Qatar (CMUQ). He also plays a key role in the collaboration between Harvard Stem Cell Institute (HSCI) and QBRI/HBKU and he is leading the first collaborative project between HSCI and QBRI.

 

Research Interests

  • Establishing in vitro hPSC-based models (patient-derived iPSCs and gene-edited hPSCs) to investigate the pathophysiology underlying the development of monogenic and polygenic forms of diabetes.
  • Generating hPSC-derived functional insulin-secreting beta cells for cell therapy

Experience

Assistant Professor (Joint appointment)

College of Health and Life Science (CHLS), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Qatar.

Nov. 2018 - Present

  • Assistant Professor (Joint appointment)

    College of Life Science and Engineering (CSE), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Qatar.

    July 2015 - Sept. 2018

  • Scientist (Group Leader)

    Qatar Biomedical Research Institute (QBRI), HBKU, Qatar Foundation, Qatar.

    April 2014 - Present

  • Associate Professor

    Cytology & Histology Dep., Fac. of Veterinary Medicine, Suez Canal University, Egypt (on leave of absence).

    Nov. 2014 - Present

  • Research Fellow

    Stem Cell and Regenerative Medicine Center, QBRI, Qatar Foundation, Qatar.

    Sep. 2013 - Mar. 2014

  • Visiting Associate Professor

    Molecular Neuroscience Research Center (MNRC), Shiga University of Medical Science, Japan.

    Mar. 2012- Apr. 2016

  • Postdoctoral Researcher

    Japan Society for Promotion of Science (JSPS), Ministry of Education. MNRC, Shiga University of Medical Science, Japan.

    Aug. 2009 - Aug. 2011

  • Assistant Professor (Lecturer)

    Cytology & Histology Dep., Faculty of Veterinary Medicine, Suez Canal University, Egypt.

    Jun. 2009 - Nov. 2014

  • Assistant Professor

    Molecular Neuroscience Research Center (MNRC), Shiga University of Medical Science, Japan.

    Nov. 2008 - Apr. 2009

  • Assistant Lecturer

    Cytology & Histology Dep., Faculty of Veterinary Medicine, Suez Canal University, Egypt.

    Oct. 2002 - Jun. 2009

  • Demonstrator (Teaching Assistant)

    Cytology & Histology Department, Faculty of Veterinary Medicine, Suez Canal University, Egypt.

    Dec. 1999 - Oct. 2002

Education

PhD (Doctor of Philosophy in Medical Science)

Graduate School of Medicine, Shiga University of Medical Science, Japan.

2009

  • MVSc (Master’s degree in Vet. Science)

    Cytology and Histology Dep., Faculty of Veterinary Medicine, Suez Canal University, Egypt.

    2002

  • BVM (Bachelor of Veterinary Medicine)

    Faculty of Veterinary Medicine, Suez Canal University, Egypt.

    1998

Selected Publications

  • Elsayed AK, Younis I, Ali G, Hussain K, Abdelalim EM*

    Aberrant development of pancreatic beta cells derived from human iPSCs with FOXA2 deficiency. Cell Death & Disease, in press.

     2021

  • Abdelalim EM*

    Modeling different types of diabetes using human pluripotent stem cells. Cellular and Molecular Life Sciences, in press.

     2020

  • Aigha I, Abdelalim EM*

    NKX6.1 transcription factor: A crucial regulator of pancreatic β-cell development, identity, and proliferation. Stem Cell Research & Therapy, 2020 Oct 29;11(1):459.

     2020

  • Al-Khawaga S, Abdelalim EM*

    Potential application of mesenchymal stem cells and their exosomes in lung injury: an emerging therapeutic option for COVID-19 patients. Stem Cell Research & Therapy, 2020, 2020 Oct 15;11(1):437.

     2020

  • Memon B, Younis I, Abubaker F, Abdelalim EM*

    PDX1-/NKX6.1+ progenitors derived from human pluripotent stem cells as a novel source of insulin-secreting cells. Diabetes Metab Res Rev. 2020 Aug 28;e3400.

     2020

  • Abu Aqel YW, Ali G, Elsayed AK, Al-Khawaga S, Hussain K, Abdelalim EM*

    Generation of two human iPSC lines from patients with maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes due to mutations in the GCK gene. Stem Cell Research, 2020 Oct; 48:101991.

     2020

  • Ali G, Elsayed AK, Nandakumar M, Bashir M, Younis I, Abu Aqel Y, Memon B, Temanni R, Abubaker F, Taheri S, Abdelalim EM*

    Keratinocytes derived from patient-specific induced pluripotent stem cells recapitulate the genetic signature of psoriasis disease. Stem Cells and Development, 2020 Apr 1;29(7):383-400.

    2020

  • Karam M, Younis I, Elareer NR, Nasser S, Abdelalim EM*

    Scalable Generation of Mesenchymal Stem Cells and Adipocytes from Human Pluripotent Stem Cells. Cells, 9(3), 710.

    2020

  • Elsayed AK, Aghadi M, Al-Khawaga S, Hussain K, Abdelalim EM*

    Derivation of a human induced pluripotent stem cell line (QBRIi007-A) from a patient carrying a homozygous intronic mutation (c.613-7T>G) in the SLC2A2 gene. Stem Cell Research, 2020 Feb 24;44:101736.

     2020

  • Memon B and Abdelalim EM*

    Stem cell therapy for diabetes: beta cells versus pancreatic progenitors. Cells, 9 (2): pii: E283.

     2020

  • Elsayed AK, Aghadi M, Ali G, Al-Khawaga S, Hussain K, Abdelalim EM*

    Generation of a human induced pluripotent stem cell line (QBRIi009-A) from a patient with a heterozygous deletion of FOXA2. Stem Cell Research, 42, 101705.

     2020

  • Aigha II, Memon B, Elsayed AK, Abdelalim EM*

    Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors. Stem Cell Research & Therapy, 9(1):83.

     2018

  • Memon B, Karam M, Al-Khawaga S, Abdelalim EM*

    Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1. Stem Cell Research & Therapy, 2018, 9:15.

     2018

  • Al-Khawaga S, Memon B, Butler AE, Taheri S, Abou-Samra AB, and Abdelalim EM*

    Pathways governing development of stem cell-derived pancreatic β cells: lessons from embryogenesis. Biol Rev Camb Philos Soc. 93(1):364-389.

     2018

  • Magdeldin S, Yamamoto T, Tooyama I, Abdelalim EM*

    New proteomic insights on the role of NPR-A in regulating self-renewal of embryonic stem cells. Stem Cell Reviews and Reports, 2014 Aug; 10 (4): 561-72.

     2014

  • Abdelalim EM*, Bonnefond A, Bennaceur-Griscelli A, Froguel P

    Pluripotent stem cells as a potential tool for disease modelling and cell therapy in diabetes. Stem Cell Reviews and Reports, 10 (3): 327-337.

     2014

  • Abdelalim EM*, Tooyama I

    NPR-A regulates self-renewal and pluripotency of embryonic stem cells. Cell Death & Disease, 2: e127.

     2011
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