Nico Marr

Dr. Nico Marr

Adjunct Associate Professor

College of Health and Life Sciences

Emailnmarr@sidra.org
Phone+974 - 4003 7568
Office locationC6-319, Level 6, Outpatient Clinic Building, Sidra Medicine

Biography

Dr. Nico Marr is a Principal Investigator leading the Laboratory of Immunogenetics in Infectious Diseases and holds an adjunct faculty appointment with the College of Health and Life Sciences at Hamad bin Khalifa University. He received his doctoral degree from the Julius-Maximilian-University of Würzburg, Germany, for studies in the field of microbiology and immunology. His dissertation and early postdoctoral research at the University of British Columbia in Vancouver, Canada, focused on host-pathogen interactions and immune evasion mechanisms of Bordetella pertussis, the etiological agent of whooping cough. Dr. Marr then completed a second postdoctoral fellowship in respiratory health and worked as a Research Associate at the British Columbia Children's Hospital Research Institute in Vancouver and the Canadian Center for Vaccinology located at the IWK Health Centre in Halifax, investigating human immune defenses in early life against common viral infections. He joined Sidra Medicine as an independent investigator in 2015. His research team studies the functional effects of human germline-genetic variants and other factors on the outcome of common childhood infections.

Research Interests

Immunogenetics
Host-pathogen Interactions
Systems Immunology
Primary Immunodeficiency

Experience

Adjunct Associate Professor

College of Health and Life Sciences, Hamad Bin Khalifa University

2021 – Present

Principal Investigator

Associate Level, Sidra Medicine
2021 – Present
Adjunct Assistant Professor

College of Health and Life Sciences, Hamad bin Khalifa University
2018 – 2021
Investigator and Research Group Leader

Sidra Medicine
2015 – Present
Research Associate

Canadian Center for Vaccinology, IWK Health Centre and Dept. of Pediatrics, Dalhousie University
2014 – 2015

Research Associate

BC Children's Hospital Research Institute and Dept. of Pediatrics, University of British Columbia
2009 – 2014
Postdoctoral Research Fellow / Research Associate

Dept. of Microbiology and Immunology, University of British Columbia
2007 – 2009
Visiting Scholar

Dept. of Microbiology & Immunology, University of British Columbia
2003 – 2007

Education

Dr. rer. nat. (equiv. to Ph.D.)

Julius Maximilian University of Würzburg, Germany

2007

Dipl.-Biol. Univ. (University Diploma in Biology)

Julius Maximilian University of Würzburg, Germany
2002

Selected Publications

Guennoun A, Bougarn S, Khan T, Mackeh R, Rahman M, Al-Ali F, Ata M, Aamer W, Prosser D, Habib T, Chin-Smith E, Al-Darwish K, Zhang Q, Al-Shakaki A, Robay A, Crystal RG, Fakhro K, Al-Naimi A, Al Maslamani E, Tuffaha A, Janahi I, Janahi M, Love DR, Karim MY

A Novel STK4 Mutation Impairs T Cell Immunity Through Dysregulation of Cytokine-Induced Adhesion and Chemotaxis Genes. J Clin Immunol. 2021 Nov;41(8):1839-1852. doi: 10.1007/s10875-021-01115-2.
2021
Khan T, Rahman M, Ali FA, Huang SSY, Ata M, Zhang Q, Bastard P, Liu Z, Jouanguy E, Béziat V, Cobat A, Nasrallah GK, Yassine HM, Smatti MK, Saeed A, Vandernoot I, Goffard JC, Smits G, Migeotte I, Haerynck F, Meyts I, Abel L, Casanova JL, Hasan MR, Marr N

Distinct antibody repertoires against endemic human coronaviruses in children and adults. JCI Insight. 2021 Feb 22;6(4):e144499. doi: 10.1172/jci.insight.144499.
2021
Hasan MR, Rahman M, Khan T, Saeed A, Sundararaju S, Flores A, Hawken P, Rawat A, Elkum N, Hussain K, Tan R, Tang P, Marr N

Virome-wide serological profiling reveals association of herpesviruses with obesity. Sci Rep. 2021 Jan 28;11(1):2562. doi: 10.1038/s41598-021-82213-4.
2021
Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency

J Exp Med. 2018 Aug 24. pii: jem.20180628. doi: 10.1084/jem.20180628. *equal contribution

Hernandez N, Melki I, Jing H, Habib T, Huang SSY, Danielson J, Kula T, Drutman, S, Belkaya S, Rattina V, Lorenzo-Diaz L, Boulai A, Rose Y, Kitabayashi N, Rodero MP, Dumaine C, Blanche S, Lebras MN, Leung MC, Mathew LS, Boisson B, Zhang SY, Boisson-Dupuis S, Giliani S, Chaussabel D, Notarangelo LD, Elledge SJ, Ciancanelli MJ, Abel L*, Zhang Q*, Marr N*, Crow YJ*, Su HC*, Casanova JL
2018
IRF4 haploinsufficiency in a family with Whipple's disease

Elife. 2018 Mar 14;7. pii: e32340. doi: 10.7554/eLife.32340.

Guérin A, Kerner G*, Marr N*, Markle JG, Fenollar F, Wong N, Boughorbel S, Avery DT, Ma CS, Bougarn S, Bouaziz M, Béziat V, Della Mina E, Oleaga-Quintas C, Lazarov T, Worley L, Nguyen T, Patin E, Deswarte C, Martinez-Barricarte R, Boucherit S, Ayral X, Edouard S, Boisson-Dupuis S, Rattina V, Bigio B, Vogt G, Geissmann F, Quintana-Murci L, Chaussabel D, Tangye SG, Raoult D, Abel L, Bustamante J, Casanova JL
2018
Respiratory syncytial virus-neutralizing serum antibody titers in infants following palivizumab prophylaxis with an abbreviated dosing regimen

PLoS One. 2017 Apr 24;12(4):e0176152. doi: 10.1371/journal.pone.0176152

Claydon J, Sur A, Callejas A, Ladd M, Kwan E, Taylor R, Turvey SE, Solimano A, Lavoie PM, Marr N.
2017
Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblasts

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E514-E523. doi: 10.1073/pnas.1620139114. *equal contribution

Della Mina E, Borghesi A, Zhou H, Bougarn S, Boughorbel S, Israel L, Meloni I, Chrabieh M, Ling Y, Itan Y, Renieri A, Mazzucchelli I, Basso S, Pavone P, Falsaperla R, Ciccone R, Cerbo RM, Stronati M, Picard C, Zuffardi O, Abel L, Chaussabel D*, Marr N*, Li X*, Casanova JL, Puel A.
2017
A curated transcriptome dataset collection to investigate the functional programming of human hematopoietic cells in early life

F1000Res. 2016 Mar 30;5:414. doi: 10.12688/f1000research.8375.1.

Rahman M, Boughorbel S, Presnell S, Quinn C, Cugno C, Chaussabel D, Marr N.
2016
Outcomes of Respiratory Syncytial Virus Immunoprophylaxis in Infants Using an Abbreviated Dosing Regimen of Palivizumab

JAMA Pediatr. 2016 Feb;170(2):174-6. doi: 10.1001/jamapediatrics.2015.3235

Lavoie PM, Solimano A, Taylor R, Kwan E, Claydon J, Turvey SE, Marr N.
2016
Assessment of genetic associations between common single nucleotide polymorphisms in RIG-I-like receptor and IL-4 signaling genes and severe respiratory syncytial virus infection in children: a candidate gene case-control study

PLoS One. 2014 Jun 20;9(6):e100269. doi: 10.1371/journal.pone.0100269

Marr N, Hirschfeld AF, Lam A, Wang S, Lavoie PM, Turvey SE
2014
Hierarchical maturation of innate immune defences in very preterm neonates

Neonatology. 2014;106(1):1-9. doi: 10.1159/000358550

Sharma AA, Jen R, Brant R, Ladd M, Huang Q, Skoll A, Senger C, Turvey SE, Marr N, Lavoie PM
2014
Attenuation of respiratory syncytial virus-induced and RIG-I-dependent type I IFN responses in human neonates and very young children

J Immunol. 2014 Feb 1;192(3):948-57. doi: 10.4049/jimmunol.1302007

Marr N, Wang TI, Kam SH, Hu YS, Sharma AA, Lam A, Markowski J, Solimano A, Lavoie PM, Turvey SE
2014
Pathogen recognition receptor crosstalk in respiratory syncytial virus sensing: a host and cell type perspective

Trends Microbiol. 2013 Nov;21(11):568-74. doi: 10.1016/j.tim.2013.08.006

Marr N, Turvey SE, Grandvaux N
2013
IL-4Rα on CD4+ T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates

J Leukoc Biol. 2013 Jun;93(6):933-42. doi: 10.1189/jlb.1012498

You D, Marr N, Saravia J, Shrestha B, Lee GI, Turvey SE, Brombacher F, Herbert DR, Cormier SA
2013
Role of human TLR4 in respiratory syncytial virus-induced NF-κB activation, viral entry and replication

Innate Immun. 2012 Dec;18(6):856-65. doi: 10.1177/1753425912444479

Marr N, Turvey SE
2012
Bordetella pertussis autotransporter Vag8 binds human C1 esterase inhibitor and confers serum resistance

PLoS One. 2011;6(6):e20585. doi: 10.1371/journal.pone.0020585

Marr N, Shah NR, Lee R, Kim EJ, Fernandez RC
2011
Variability in the lipooligosaccharide structure and endotoxicity among Bordetella pertussis strains

J Infect Dis. 2010 Dec 15;202(12):1897-906. doi: 10.1086/657409

Marr N, Novikov A, Hajjar AM, Caroff M, Fernandez RC
2010
Substitution of the Bordetella pertussis lipid A phosphate groups with glucosamine is required for robust NF-kappaB activation and release of proinflammatory cytokines in cells expressing human but not murine Toll-like receptor 4-MD-2-CD14

Infect Immun. 2010 May;78(5):2060-9. doi: 10.1128/IAI.01346-09

Marr N, Hajjar AM, Shah NR, Novikov A, Yam CS, Caroff M, Fernandez RC
2010
Protective activity of the Bordetella pertussis BrkA autotransporter in the murine lung colonization model

Vaccine. 2008 Aug 12;26(34):4306-11. doi: 10.1016/j.vaccine.2008.06.017. *equal contribution

Marr N*, Oliver DC*, Laurent V, Poolman J, Denoël P, Fernandez RC
2008
Glucosamine found as a substituent of both phosphate groups in Bordetella lipid A backbones: role of a BvgAS-activated ArnT ortholog

J Bacteriol. 2008 Jun;190(12):4281-90. doi: 10.1128/JB.01875-07

Marr N, Tirsoaga A, Blanot D, Fernandez R, Caroff M
2008
Bordetella pertussis binds human C1 esterase inhibitor during the virulent phase, to evade complement-mediated killing

J Infect Dis. 2007 Feb 15;195(4):585-8. doi: 10.1086/510913

Marr N, Luu RA, Fernandez RC.
2007

College of Health and Life Sciences CHLS Hamad Bin Khalifa University Hamad Bin Khalifa University

FACULTY BIOGRAPHIES

Dr. Nico Marr

Biography

Research Interests

Experience

Adjunct Associate Professor

Principal Investigator

Adjunct Assistant Professor

Investigator and Research Group Leader

Research Associate

Research Associate

Postdoctoral Research Fellow / Research Associate

Visiting Scholar

Education

Dr. rer. nat. (equiv. to Ph.D.)

Dipl.-Biol. Univ. (University Diploma in Biology)

Selected Publications

Guennoun A, Bougarn S, Khan T, Mackeh R, Rahman M, Al-Ali F, Ata M, Aamer W, Prosser D, Habib T, Chin-Smith E, Al-Darwish K, Zhang Q, Al-Shakaki A, Robay A, Crystal RG, Fakhro K, Al-Naimi A, Al Maslamani E, Tuffaha A, Janahi I, Janahi M, Love DR, Karim MY

Khan T, Rahman M, Ali FA, Huang SSY, Ata M, Zhang Q, Bastard P, Liu Z, Jouanguy E, Béziat V, Cobat A, Nasrallah GK, Yassine HM, Smatti MK, Saeed A, Vandernoot I, Goffard JC, Smits G, Migeotte I, Haerynck F, Meyts I, Abel L, Casanova JL, Hasan MR, Marr N

Hasan MR, Rahman M, Khan T, Saeed A, Sundararaju S, Flores A, Hawken P, Rawat A, Elkum N, Hussain K, Tan R, Tang P, Marr N

Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency

IRF4 haploinsufficiency in a family with Whipple's disease

Respiratory syncytial virus-neutralizing serum antibody titers in infants following palivizumab prophylaxis with an abbreviated dosing regimen

Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblasts

A curated transcriptome dataset collection to investigate the functional programming of human hematopoietic cells in early life

Outcomes of Respiratory Syncytial Virus Immunoprophylaxis in Infants Using an Abbreviated Dosing Regimen of Palivizumab

Assessment of genetic associations between common single nucleotide polymorphisms in RIG-I-like receptor and IL-4 signaling genes and severe respiratory syncytial virus infection in children: a candidate gene case-control study

Hierarchical maturation of innate immune defences in very preterm neonates

Attenuation of respiratory syncytial virus-induced and RIG-I-dependent type I IFN responses in human neonates and very young children

Pathogen recognition receptor crosstalk in respiratory syncytial virus sensing: a host and cell type perspective

IL-4Rα on CD4+ T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates

Role of human TLR4 in respiratory syncytial virus-induced NF-κB activation, viral entry and replication

Bordetella pertussis autotransporter Vag8 binds human C1 esterase inhibitor and confers serum resistance

Variability in the lipooligosaccharide structure and endotoxicity among Bordetella pertussis strains

Substitution of the Bordetella pertussis lipid A phosphate groups with glucosamine is required for robust NF-kappaB activation and release of proinflammatory cytokines in cells expressing human but not murine Toll-like receptor 4-MD-2-CD14

Protective activity of the Bordetella pertussis BrkA autotransporter in the murine lung colonization model

Glucosamine found as a substituent of both phosphate groups in Bordetella lipid A backbones: role of a BvgAS-activated ArnT ortholog

Bordetella pertussis binds human C1 esterase inhibitor during the virulent phase, to evade complement-mediated killing