Puthen Veettil Jithesh | Hamad Bin Khalifa University
Hamad Bin Khalifa University


Puthen Veettil Jithesh

Dr. Puthen Veettil Jithesh

Associate Dean for Education/Student Affairs
College of Health and Life Sciences

  • Phone50 632 102
  • Office locationB-137, First Floor, LAS (Penrose) Building


Dr. Puthen Veettil Jithesh holds a Master’s degree in Microbiology, an Advanced Diploma in Bioinformatics, and received his PhD in Bioinformatics from Queen’s University Belfast, UK. He has over 20 years of research and development experience in Bioinformatics and Computational Biology at several prestigious institutes in India, Qatar, and Russell Group research universities in the UK.

Before moving to Qatar, he was the Head of Bioinformatics for the Oxford Translational Molecular Diagnostic Centre at the University of Oxford and held honorary appointments with the Wellcome Centre for Human Genetics and the Oxford University Hospitals NHS Trust.


Research Interests

  • Bioinformatics and computational biology tool development and applications in translational research
  • Pharmacogenomics for the prediction of response and toxicity to drugs
  • Identification of causal variants in rare genetic diseases
  • Machine learning and data science toward the implementation of precision medicine


Associate Professor

College of Health and Life Sciences; Hamad Bin Khalifa University, Doha, Qatar

2020 - Present
  • Associate Professor (Adjunct)

    College of Health and Life Sciences; Hamad Bin Khalifa University, Doha, Qatar

    2018 - 2020
  • Principal Investigator

    Translational Bioinformatics; Sidra Medicine, Doha, Qatar

    2015 – 2019
  • Head of Bioinformatics

    Translational Molecular Diagnostic Centre; University of Oxford, United Kingdom

    2014 – 2015
  • Senior Bioinformatician (Bioinformatics Lead)

    Institute of Translational Medicine; University of Liverpool, United Kingdom

    2010 – 2014
  • Co-Founder & Director

    HealthIntec Limited, Belfast, United Kingdom

    2008 – 2012
  • Senior Research Fellow (Bioinformatics)

    Centre for Cancer Research & Cell Biology; Queen’s University, Belfast, United Kingdom

    2006 – 2010
  • Bioinformatician; Belfast e-Science Centre

    Queen’s University, Belfast, United Kingdom

    2003 – 2005
  • Member Technical Staff (MTS) Bioinformatics

    Centre for Development of Advanced Computing (C-DAC), Pune, India

    1999 – 2003
  • Senior Project Assistant (Bioinformatics)

    Bioinformatics Centre; Indian Institute of Technology (IIT), Kharagpur, India

    1999 - 1999
  • Lecturer in Microbiology

    School of Medical Education; Mahatma Gandhi University, Kerala, India

    1996 - 1998


Doctor of Philosophy (PhD), Bioinformatics

Queen’s University Belfast; Northern Ireland, United Kingdom

  • Advanced Diploma in Bioinformatics

    University of Pune (Now Savitribai Phule Pune University); Maharashtra, India

  • Master of Science (MSc)

    Microbiology; Mahatma Gandhi University; Kerala, India

  • Bachelor of Science (BSc)

    Botany; University of Calicut; Kerala, India


Selected Publications

  • Al-Khawaga S, Saraswathi S, Mohammed I, Haris B, Hasnah R, Saeed A, Almabrazi H, Syed N, Jithesh P, Elawa A, Khalifa A, AlKhalaf F, Petrovski G, Abdelalim E, Hussain K

    Clinical Characteristics and Genomics of Permanent Neonatal Diabetes in The State of Qatar; Molecular Genetics & Genomic Medicine; 2019 (https://doi.org/10.1002/mgg3.753)

  • Najgebauer H, Liloglou T, Jithesh PV, Giger O, Varro A, Sanderson CM

    Integrated Omics Profiling Reveals Novel Patterns of Epigenetic Programming in Cancer-Associated Myofibroblasts; Carcinogenesis 2019, 40(4):500–512 (doi:10.1093/carcin/bgz001)

  • Transcriptional subtyping and CD8 immunohistochemistry identifies poor prognosis stage II/III colorectal cancer patients who benefit from adjuvant chemotherapy; Journal of Clinical Oncology: Precision Oncology; 2018 (doi:10.1200/PO.17.00241)

    Allen WL, Dunne PD, McDade S, Scanlon E, Loughrey M, Coleman H, McCann C, McLaughlin K, Nemeth Z, Syed N, Jithesh PV, Arthur K, Wilson R, Coyle V, McArt D, Murray G, Samuel L, Nuciforo P, Jimenez J, Argiles G, Dienstmann R, Tabernero J, Messerini L, Nobili S, Mini E, Sheahan K, Ryan E, Johnston PG, Van Schaeybroeck S, Lawler M, Longley DB

  • Jithesh PV and Scaria V

    From Genomes to Genomic Medicine - Enabling Personalised and Precision Medicine in the Middle East; Personalized Medicine; 1 Sep 2017 (doi:10.2217/pme-2017-0048)

  • Kathiresan N, Temanni R, Almabrazi H, Syed N, Jithesh PV, Al-Ali R

    Accelerating next generation sequencing data analysis with system level optimizations; Scientific Reports 2017, 7:9058 (doi:10.1038/s41598-017-09089-1)

  • Hasan MR, Rawat A, Tang P, Jithesh PV, Thomas E, Tan R, Tilley P

    Depletion of human DNA in clinical specimens for detection of pathogens by shotgun metagenomic sequencing; Journal of Clinical Microbiology 2016, 54(4):919-27

  • Mégarbané A, Al-Ali R, Choucair N, Lek M, Wang E, Ladjimi M, Rose CM, Hobeika R, Macary Y, Temanni R, Jithesh PV, Chouchane A, Sastry KS, Thomas R, Tomei S, Liu W, MacArthur D, Marincola F, Chouchane L

    Temple-Baraitser Syndrome and Zimmermann-Laband Syndrome: one clinical entity?;BMC Medical Genetics; 2016, 17(1):42

  • Van Schaeybroeck S, Kalimutho M, Dunne P, Carson R, Allen WL, Jithesh PV, Redmond K, Sasazuki T, Shirasawa S, Blayney J, Michieli P, Fenning C, Lenz H-J, Lawler M, Longley D, Johnston PG

    ADAM17-Dependent c-MET-STAT3 Signaling Mediates Resistance to MEK Inhibitors in KRAS Mutant Colorectal Cancer; Cell Reports; 2014, 7(6):1940-55

  • Jithesh PV, Risk JM, Schache AG, Dhanda J, Lane B, Liloglou T, Shaw RJ

    The Epigenetic Landscape of Oral Squamous Cell Carcinoma; British Journal of Cancer; 2013, 108:370-379

  • Jithesh PV, Donachy P, Harmer T, Kelly N, Perrott R, Wasnik S, Johnston J, McCurley M, Townsley M, McKee S

    GeneGrid: architecture, implementation and application; Journal of Grid Computing; 2006, 4:209-222

  • Kong X-F, Worley L, Rinchai D, Bondet V, Duffy D, Jithesh PV, Goulet M, Nonnotte E, Rebillat A, Conte M, Mircher C, Gürtler N, Liu L, Migaud M, Elanbari M, Habib T, Ma C, Bustamante J, Abel L, Ravel A, Lyonnet S, Munnich A, Duffy D, Chaussabel D, Casanova

    Three copies of four interferon receptor genes underlie mucocutaneous candidiasis and auto-immune thyroiditis in patients with Down Syndrome. Journal of Clinical Immunology (https://doi.org/10.1007/s10875-020-00803-9)

  • Umar M, Megarbane A, Shan X, Syed N, Chouery E, Aliyev E, Jithesh P, Temanni R, Mansour I, Chouchane L, Chouchane A

    Genome sequencing unveils mutational landscape of the familial Mediterranean fever: Potential implications of IL33/ST2 signalling. Journal of Cellular and Molecular Medicine (https://doi.org/10.1111/jcmm.15701)