Work featured in Proceedings of the National Academy of Sciences
Dr. Kabir H. Biswas, Assistant Professor at Hamad Bin Khalifa University’s (HBKU) College of Health and Life Sciences (CHLS), has published a COVID-19-related research manuscript in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) journal.
Dr. Biswas, along with PhD in Biological and Biomedical Sciences/CHLS student, Mr. Wesam S. Ahmed (working with Dr. Biswas), collaborated with Yale University researchers on the project, titled “SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression.”
The paper outlined the team’s work in understanding the mechanism of interaction between SARS-CoV-2 protein ORF7a and human major histocompatibility complex class I (MHC-I) protein. Their research showed how the ORF7a protein can bind to the MHC-I molecule and outcompete its cognate partner, and thus aid SARS-CoV-2 in evading immune response.
The full research article can be accessed at https://www.pnas.org/doi/10.1073/pnas.2208525120