Unraveling the Molecular Basis of Synucleinopathies: From Biology to Pathology | Hamad Bin Khalifa University
Hamad Bin Khalifa University


Unraveling the Molecular Basis of Synucleinopathies: From Biology to Pathology


Welcome to an insightful exploration of protein misfolding and aggregation in neurodegenerative disorders. This event sheds light on the complexities of Alzheimer’s and Parkinson’s disease (PD), two prevalent conditions where protein misfolding plays a significant role.In our discussion, we will consider both aging and familial forms linked to gene mutations as primary risk factors for neurodegenerative diseases.

A particular focus will be placed on Parkinson’s disease, examining the aggregation of alpha-synuclein (ASYN) into Lewy bodies and the consequential loss of dopaminergic neurons in the substantia nigra—characteristic pathological features of PD.

The event will address the challenges associated with the complex molecular mechanisms governing protein aggregation and neurodegeneration, hindering the development of innovative therapeutic approaches.

We are honored to feature Dr. Tiago Fleming Outeiro, Director of the Department of Experimental Neurodegeneration at the University Medical Center Goettingen, Germany, as our distinguished speaker. Dr. Tiago employs diverse model organisms and cutting-edge molecular techniques to delve into the molecular underpinnings of neurodegeneration. Attendees will have the opportunity to learn about the use of advanced cellular models to replicate key aspects of dysfunction and the application of powerful imaging methods to explore protein-protein interactions impacting conformational changes.

We invite you to join us for an engaging discussion and be part of the exploration of innovative therapeutic approaches.