FACULTY BIOGRAPHIES
Dr. Fadel Tissir (PhD)
- Emailftissir@hbku.edu.qa
- Office locationB130
Biography
Fadel Tissir graduated in Biology from University Sidi Mohammed ben Abdellah, Fes, Morocco; and earned his MSc degree from Liège University and PhD from the Free University of Brussels, Belgium. He worked as a postdoc on genetic factors predisposing to psychiatric disorders at the University of Antwerp from 1998 to 2000.
He authored over 80 peer-reviewed publications and serves as a regular reviewer for many journals including Nature, Science, Nature Neuroscience, Nature Communications, PNAS, and funding agencies. He is a member of several scientific societies and editor at eLife and Frontiers in Neuroscience.
Research Interests
-
Assess the role of DIAPH3 in glioblastoma development and progression.
-
Explore the relationship between DIAPH3 expression levels and sensitivity to temozolomide chemotherapy.
-
Evaluate the impact of CELSR1 mutations on cognitive functions.
-
Investigate the role of CELSR2/3 during development and regeneration of the nervous system.
Experience
Assistant Professor
University of Louvain
2001 - 2005Associate Professor
University of Louvain
2005 - 2018Professor
University of Louvain
2018 - 2020Research Associate
National Funds for Scientific Research (FNRS)
2005 - 2013Senior Research Associate
FNRS
2013 - 2017
Research Director
FNRS
2017 - 2020Associate professor
University of Louvain
2005 - 2018Head of Molecular and Cellular Neuroscience Division.
2013 - 2020
Education
B.Sc. Biology
University Sidi Mohammed ben Abdellah, Fes, Morocco.
1987-1990M.Sc. Molecular Biology & Biotechnology
University of Liège, Liège, Belgium
1990-1992
Ph.D. Science
Free University of Brussels, Brussels, Belgium.
1993-1998
Selected Publications
-
Aragona M, Sifrim A, Malfait M, Song Y, Van Herck J, Dekoninck S, Gargouri S, Lapouge G, Swedlund B, Dubois C, Baatsen P, Vints K, Han S, Tissir F, Voet T, Simons BD, Blanpain C.
Mechanisms of stretch-mediated skin expansion at single-cell resolution. Nature 584:268-273 (2020)
2020 -
Boucherie C, Boutin C, Jossin Y, Schakman O, Goffinet AM, Ris L, Gailly P, Tissir F.
Neural progenitor fate decision defects, cortical hypoplasia and behavioral impairment in Celsr1-deficient mice. Molecular Psychiatry 23:723-734 (2018).
2018 -
Damiani D, Goffinet AM, Alberts A, Tissir F.
Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors. Nature Communications 13509 (2016)
2016 -
Chai G, Zhou L, Manto M, Helmbacher F, Clotman F, Goffinet AM, Tissir F.
Celsr3 is required in motor neurons to steer their axons in the hindlimb. Nature Neuroscience 17, 1171-1179 (2014).
2014 -
Boutin C, Labedan P, Dimidschstein J, Richard F, Cremer H, André P, Yang Y, Montcouquiol M, Goffinet AM, Tissir F.
A dual role for planar cell polarity genes in ciliated cells. Proceedings of the National Academy of Sciences of the United States of America 111, E3129-3138 (2014).
2014 -
Tissir F & Goffinet AM.
Shaping the nervous system: Role of the planar cell polarity genes. Nature Reviews Neuroscience 14:525-35 (2013)
2013 -
Qu Y, Glasco DM, Zhou L, Sawant A, Ravni A, Fritzsch B, Damrau C, Jennifer N. Murdoch JN, Evans S, Pfaff S, Formstone C, Goffinet AM, Chandrasekhar A, Tissir F.
Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. The Journal of Neuroscience 30:9392-40 (2010)
2010 -
Tissir F, Qu Y, Montcouquiol M, Zhou L, Komatsu K, Shi D, Fujimori T, Labeau J, Tyteca D, Courtoy P, Poumay Y, Uemura T, Goffinet AM.
Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nature Neuroscience 13:700-7 (2010)
2010 -
Tissir F, Ravni A, Achouri Y, Riethmacher D, Meyer G, Goffinet AM.
DeltaNp73 regulates neuronal survival in vivo. Proceedings of the National Academy of Sciences of the United States of America 106: 16871-16876 (2009)
2009 -
Zhou L, Bar I, Achouri Y, Campbell K, De Backer O, Hebert JM, Jones K, Kessaris N, de Rouvroit CL, O'Leary D, Richardson WD, Goffinet AM, Tissir F.
Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice. Science 320: 946-9 (2008)
2008 -
Tissir F, Bar I, Jossin Y, De Backer O, Goffinet AM.
Protocadherin Celsr3 is crucial in axonal tract development. Nature Neuroscience 8: 451-457 (2005)
2005
MYHBKU LOGIN