Dr. Abdelilah Arredouani joined QBRI in March 2012 as a Scientist in the Diabetes Research Center. He holds a PhD in Biomedical Sciences from the Faculty of Medicine at University of Louvain-La-Neuve in Belgium. Prior to joining QBRI he worked in Netherlands at the Department of Neurosciences in Erasmus Medical Center in Rotterdam, in United Kingdom at the Department of Pharmacology in Oxford University, and in Qatar at the Department of Physiology and Biophysics in Weill Cornell Medicine. During his PhD, he studied the contribution of the calcium stores in the endoplasmic reticulum to glucose-induced calcium response and insulin secretion from the pancreatic beta cell in the context of type 2 diabetes.
Dr. Arredouani was a key player in the discovery of the NAADP receptor, the two pore channels, and Ned-19, a specific antagonist of the NAADP. Since joining QBRI in 2012, Dr. Arredouani has been involved in projects related to the identification of biomarkers to predict type 2 diabetes using systems biology approaches. He has published in high impact peer-reviewed journals including Nature, Nature Chemical Biology, Current Biology, Diabetes and JBC.
Dr. Arredouani’s research focuses mainly on the identification of biomarkers to predict type 2 diabetes and its complications. He combines molecular and cellular techniques with systems biology approaches, including metabolomics and miRNA profiling, in his investigations.
Advances in human metabolism and disease (LS642)
Signal Transduction in Health and Diseases (LS641)
OMICS (GPM 603)
Life Science Graduate Advisory committee
Khaoula Eraafii: P.h.D student
Diagnostic, Prognostic, and Mechanistic Biomarkers of Diabetes Mellitus-Associated Cognitive Decline. Int J Mol Sci. 2022; 23(11):6144.2022
Comparative Transcriptome Analysis Reveals That Exendin-4 Improves Steatosis in HepG2 Cells by Modulating Signaling Pathways Related to Lipid Metabolism. Biomedicines. 2022;10(5):1020.2022
Identification of Novel Circulating miRNAs in Patients with Acute Ischemic Stroke. Int J Mol Sci. 2022 Mar 21;23(6):3387.2022
Elevated levels of salivary α- amylase activity in saliva associated with reduced odds of obesity in adult Qatari citizens: A cross-sectional study. Plos One. 2022 Mar 10; 17(3):e0264692. Al-Akl N, Thompson IR, Arredouani A*.2022
Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study. Sci Rep. 2021 Jun 1;11(1):11495.2021
Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway. Sci Rep. 2022 Feb 9;12(1):2226.2022
Comprehensive analysis of LncRNAs expression profiles in an in vitro model of steatosis treated with Exendin-4. J Transl Med. 2021 Jun 2;19(1):235.2021
Metabolomic Profile of Low Copy-Number Carriers at the Salivary Alpha-Amylase Gene Suggests a Metabolic Shift Towards Lipid-Based Energy Production. Diabetes. 2016 Nov;65(11):3362-33682016
Beverley Balkau, Amélie Bonnefond; Philippe Froguel. Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling. Mol Metab. 2016 Aug 23;5(10):918-252016
Role for NAADP activation of two-pore channels in stimulus-secretion coupling in mouse pancreatic beta cells, J Biol Chem. 2015 Aug 28;290(35):21376-922015
Mechanisms behind the immediate effects of Roux-en-Y gastric bypass surgery on type 2 diabetes, Theor Biol Med Model. 2013 Jul 13;10(1):45.2013
NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature. 2009 May 28;459(7246):596-600.2009
Identification of a chemical probe for NAADP by virtual screening. Nat Chem Biol. 2009 Feb 22.2009
List of Publications on Pubmed