Dr. Abdelilah Arredouani | Hamad Bin Khalifa University
Hamad Bin Khalifa University

FACULTY BIOGRAPHIES

abdelilah_arredouani

Dr. Abdelilah Arredouani


Scientist
Qatar Biomedical Research Institute QBRI
Diabetes Research Center

Joint Assistant Professor
College of Health and Life Sciences

  • Phone+974 4454 2947

Biography

Dr. Abdelilah Arredouani joined QBRI in March 2012 as a Scientist and he is a member of the Diabetes Research Center. He holds a Ph.D. in biomedical sciences from the faculty of medicine at University of Louvain-La-Neuve in Belgium. Prior to joining QBRI he worked in Netherlands at the department of neurosciences in Erasmus Medical center in Rotterdam, in United Kingdom at the Department of pharmacology in Oxford University, and in Qatar at the department of physiology and biophysics in Weill Cornell Medicine. During his Ph.D., he studied the contribution of the calcium stores in the endoplasmic reticulum to glucose-induced calcium response and insulin secretion from the pancreatic beta cell in the context of type 2 diabetes.

Dr. Arredouani was a key player in the discovery of the NAADP receptor, the two pore channels, and Ned-19, a specific antagonist of the NAADP. Since joining QBRI in 2012, Dr. Arredouani has been involved in projects related to the identification of biomarkers to predict type 2 diabetes using systems biology approaches. He has published in high impact peer-reviewed journals including nature, nature chemical biology, current biology, diabetes and JBC.

 


Research Interests

Dr. Arredouani’s research focuses mainly on the identification of biomarkers to predict type 2 diabetes and its complications. He combines molecular and cellular techniques with systems biology approaches, including metabolomics and miRNA profiling, in his investigations.

  • Fatty liver, Lifestyle and Glycaemia (FLAG): The impact of a low energy diet Intervention on non-alcoholic fatty liver disease in Type 2 Diabetes in Qatar.
  • Investigation of the association between low salivary alpha-amylase and risk of metabolic disorders in the Qatari population.
  • Mechanisms underlying the improvement of NAFLD by GLP-1 agonists.
  • Collaborator's Name: Dr. Mario Falchi Institute Name: Kings College London, United Kingdom
  • Collaborator's Name: Dr. Shahrad Teheri Institute Name: Weill Cornell Medicine-Qatar, Qatar
  • Collaborator's Name: Dr. Philippe Froguel Institute Name: University of Lille, France

Experience

Course Coordinator ( Teaching )

Advances in human metabolism and disease (LS642)

  • Tutor ( Teaching )

    Signal Transduction in Health and Diseases (LS641)

  • Tutor ( Teaching )

    OMICS (GPM 603)

  • Committees

    Life Science Graduate Advisory committee

  • MENTORING

    Khaoula Eraafii: P.h.D student

Selected Publications

  • Arredouani A* , Stocchero M, Culeddu N, El-Sayed Moustafa J; D.E.S.I.R. study group, Tichet J, Balkau B, Brousseau T, Manca M, Falchi M.

    Metabolomic Profile of Low Copy-Number Carriers at the Salivary Alpha-Amylase Gene Suggests a Metabolic Shift Towards Lipid-Based Energy Production. Diabetes. 2016 Nov;65(11):3362-3368

    2016
  • Loic Wengo, Abdelilah Arredouani, Michel Marre, Ronan Roussel, Martine Vaxillaire, Mario Falchi, Abdelali Haoudi,; The D.E.S.I.R Study Group

    Beverley Balkau, Amélie Bonnefond; Philippe Froguel. Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling. Mol Metab. 2016 Aug 23;5(10):918-25

    2016
  • Arredouani A*, Ruas M, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Shimomura K, Morgan AJ, Lewis AM, Chuang KT, Tunn T, Gadea J, Teboul L, Tynan PW, Bellomo EA, Rutter GA, Rorsman P, Churchill GC, Parrington J and Antony G

    Role for NAADP activation of two-pore channels in stimulus-secretion coupling in mouse pancreatic beta cells, J Biol Chem. 2015 Aug 28;290(35):21376-92

    2015
  • Allen RE, Hughes TD, Ng JL, Ortiz RD, Abou Ghantous M, Bouhali O, Froguel P, Arredouani A*.

    Mechanisms behind the immediate effects of Roux-en-Y gastric bypass surgery on type 2 diabetes, Theor Biol Med Model. 2013 Jul 13;10(1):45.

    2013
  • Calcraft PJ, Ruas M, Pan Z, Cheng X, Arredouani A, Hao X, Tang J, Rietdorf K, Teboul L, Chuang KT, Lin P, Xiao R, Wang C, Zhu Y, Lin Y, Wyatt CN, Parrington J, Ma J, Evans AM, Galione A, Zhu MX.

    NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature. 2009 May 28;459(7246):596-600.

    2009
  • Arredouani A*, Naylor E*, Vasudevan SR, Lewis AM, Parkesh R, Mizote A, Rosen D, Thomas JM, Izumi M, Ganesan A, Galione A, Churchill GC.

    Identification of a chemical probe for NAADP by virtual screening. Nat Chem Biol. 2009 Feb 22.

    2009
  • List of Publications on Pubmed