Dr. Abdelilah Arredouani | Hamad Bin Khalifa University
Hamad Bin Khalifa University


Dr. Abdelilah Arredouani

Dr. Abdelilah Arredouani

Senior Scientist
Diabetes Research Center
Qatar Biomedical Research Institute

College of Health and Life Sciences


Dr. Abdelilah Arredouani joined QBRI in March 2012 as a Scientist in the Diabetes Research Center. He holds a PhD in Biomedical Sciences from the Faculty of Medicine at University of Louvain-La-Neuve in Belgium. Prior to joining QBRI he worked in Netherlands at the Department of Neurosciences in Erasmus Medical Center in Rotterdam, in United Kingdom at the Department of Pharmacology in Oxford University, and in Qatar at the Department of Physiology and Biophysics in Weill Cornell Medicine. During his PhD, he studied the contribution of the calcium stores in the endoplasmic reticulum to glucose-induced calcium response and insulin secretion from the pancreatic beta cell in the context of type 2 diabetes.

Dr. Arredouani was a key player in the discovery of the NAADP receptor, the two pore channels, and Ned-19, a specific antagonist of the NAADP. Since joining QBRI in 2012, Dr. Arredouani has been involved in projects related to the identification of biomarkers to predict type 2 diabetes using systems biology approaches. He has published in high impact peer-reviewed journals including Nature, Nature Chemical Biology, Current Biology, Diabetes and JBC.

Research Interests

Dr. Arredouani’s research focuses mainly on the identification of biomarkers to predict type 2 diabetes and its complications. He combines molecular and cellular techniques with systems biology approaches, including metabolomics and miRNA profiling, in his investigations.

  • Fatty liver, Lifestyle and Glycaemia (FLAG): The impact of a low energy diet Intervention on non-alcoholic fatty liver disease in Type 2 Diabetes in Qatar.
  • Investigation of the association between low salivary alpha-amylase and risk of metabolic disorders in the Qatari population.
  • Mechanisms underlying the improvement of NAFLD by GLP-1 agonists.



  1. Dr. Mario Falchi Institute Name: Kings College London, United Kingdom
  2. Dr. Shahrad Teheri Institute Name: Weill Cornell Medicine-Qatar, Qatar
  3. Dr. Philippe Froguel Institute Name: University of Lille, France

Course Coordinator ( Teaching )

Advances in human metabolism and disease (LS642)

  • Tutor ( Teaching )

    Signal Transduction in Health and Diseases (LS641)

  • Tutor ( Teaching )

    OMICS (GPM 603)

  • Committees

    Life Science Graduate Advisory committee


    Khaoula Eraafii: P.h.D student

Selected Publications

  • Ehtewish H, Arredouani A*, El-Agnaf O*.

    Diagnostic, Prognostic, and Mechanistic Biomarkers of Diabetes Mellitus-Associated Cognitive Decline. Int J Mol Sci. 2022; 23(11):6144.

  • Errafii K, Khalifa O, Al-Akl NS, Arredouani A*.

    Comparative Transcriptome Analysis Reveals That Exendin-4 Improves Steatosis in HepG2 Cells by Modulating Signaling Pathways Related to Lipid Metabolism. Biomedicines. 2022;10(5):1020.

  • Aldous EK, Toor SM, Parray A, Al-Sarraj Y, Diboun I, Abdelalim E, Arredouani A, El-Agnaf O, Thornalley PJ, Akhtar N, Pananchikkal SV, Shuaib A, Alajez NM, Albagha OME.

    Identification of Novel Circulating miRNAs in Patients with Acute Ischemic Stroke. Int J Mol Sci. 2022 Mar 21;23(6):3387.

  • Al-Akl N, Thompson IR, Arredouani A*

    Elevated levels of salivary α- amylase activity in saliva associated with reduced odds of obesity in adult Qatari citizens: A cross-sectional study. Plos One. 2022 Mar 10; 17(3):e0264692. Al-Akl N, Thompson IR, Arredouani A*.

  • Al-Akl N, Ian R. Thompson, Abdelilah Arredouani*

    Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study. Sci Rep. 2021 Jun 1;11(1):11495.

  • Khalifa O, Al-Akl NS, Errafii K, Arredouani A*.

    Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway. Sci Rep. 2022 Feb 9;12(1):2226.

  • Errafii K, Al-Akl NS, Khalifa O, Arredouani A*

    Comprehensive analysis of LncRNAs expression profiles in an in vitro model of steatosis treated with Exendin-4. J Transl Med. 2021 Jun 2;19(1):235.

  • Arredouani A* , Stocchero M, Culeddu N, El-Sayed Moustafa J; D.E.S.I.R. study group, Tichet J, Balkau B, Brousseau T, Manca M, Falchi M.

    Metabolomic Profile of Low Copy-Number Carriers at the Salivary Alpha-Amylase Gene Suggests a Metabolic Shift Towards Lipid-Based Energy Production. Diabetes. 2016 Nov;65(11):3362-3368

  • Loic Wengo, Abdelilah Arredouani, Michel Marre, Ronan Roussel, Martine Vaxillaire, Mario Falchi, Abdelali Haoudi,; The D.E.S.I.R Study Group

    Beverley Balkau, Amélie Bonnefond; Philippe Froguel. Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling. Mol Metab. 2016 Aug 23;5(10):918-25

  • Arredouani A*, Ruas M, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Shimomura K, Morgan AJ, Lewis AM, Chuang KT, Tunn T, Gadea J, Teboul L, Tynan PW, Bellomo EA, Rutter GA, Rorsman P, Churchill GC, Parrington J and Antony G

    Role for NAADP activation of two-pore channels in stimulus-secretion coupling in mouse pancreatic beta cells, J Biol Chem. 2015 Aug 28;290(35):21376-92

  • Allen RE, Hughes TD, Ng JL, Ortiz RD, Abou Ghantous M, Bouhali O, Froguel P, Arredouani A*.

    Mechanisms behind the immediate effects of Roux-en-Y gastric bypass surgery on type 2 diabetes, Theor Biol Med Model. 2013 Jul 13;10(1):45.

  • Calcraft PJ, Ruas M, Pan Z, Cheng X, Arredouani A, Hao X, Tang J, Rietdorf K, Teboul L, Chuang KT, Lin P, Xiao R, Wang C, Zhu Y, Lin Y, Wyatt CN, Parrington J, Ma J, Evans AM, Galione A, Zhu MX.

    NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature. 2009 May 28;459(7246):596-600.

  • Arredouani A*, Naylor E*, Vasudevan SR, Lewis AM, Parkesh R, Mizote A, Rosen D, Thomas JM, Izumi M, Ganesan A, Galione A, Churchill GC.

    Identification of a chemical probe for NAADP by virtual screening. Nat Chem Biol. 2009 Feb 22.

  • List of Publications on Pubmed