Dr. Yongsoo Park | Hamad Bin Khalifa University

Qatar Biomedical Research Institute QBRI

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Hamad Bin Khalifa University

FACULTY BIOGRAPHIES

Dr. Yongsoo Park

Dr. Yongsoo Park (PhD)

Scientist
Neurological Disorders Research Center
Qatar Biomedical Research Institute
College of Health and Life Sciences
  • Phone50 156 360
  • Office locationRC-B2-1428

Biography

Dr. Park’s research is focused on biomarkers and treatment for neurodegenerative and neurodevelopmental disorders including autism spectrum disorder (ASD). He received his PhD in investigating exocytosis and plasticity of vesicle fusion using electrophysiology and live cell imaging at the POSTECH (Pohang University of Science and Technology), South Korea, after which he worked as a postdoctoral researcher at the Max-Planck-Institute for Biophysical Chemistry, Germany, being mentored by Prof. Reinhard Jahn, a world-renowned scientist with his pioneering research into fusion and neurotransmitter release. Dr. Park was appointed Assistant Professor at the Department of Molecular Biology and Genetics at the Koç University, Istanbul, Turkey, and in 2019, he moved to Hamad Bin Khalifa University (HBKU) as a Scientist at QBRI and is co-affiliated at the College of Health & Life Sciences, HBKU as an Assistant Professor, working on the development of biomarkers and treatment for ASD, Alzheimer's disease, and Parkinson’s disease.

 

Research Interests

  • Modeling neurological disorders using human induced pluripotent stem cells (hiPSC)‐derived neurons and synthetic biology
  • Extracellular vesicle biomarkers for autism spectrum disorder (ASD)
  • Molecular mechanisms of neurodegenerative diseases and development of therapeutics
  • MicroRNA exocytosis by vesicle fusion (exosome-independent) in neurons and neuroendocrine cells

Experience

Scientist

Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU)

2019 – Present

  • Joint Assistant Professor

    College of Health & Life Sciences, Hamad Bin Khalifa University (HBKU)

    2019 – Present

  • Assistant Professor

    Department of Molecular Biology and Genetics, Koç University, Istanbul, Turkey

    2017 – 2019

  • Assistant Professor

    Izmir International Biomedicine and Genome Institute, Turkey

    2015 – 2017

  • Postdoctoral researcher

    Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany

    2009 – 2015

Education

PhD in Molecular Neurobiology

POSTECH (Pohang University of Science and Technology), South Korea

2009

  • BS in Life Science

    Handong Global University, South Korea

    2001

Selected Publications

  • Shin KC, Ali G, Ali Moussa HY, Gupta V, de la Fuente A, Kim HG, Stanton LW, Park Y#. Deletion of TRPC6, an autism risk gene, induces hyperexcitability in cortical neurons derived from human pluripotent stem cells. Mol Neurobiol. 2023 Dec;60(12):7297-7308.

  • Ali Moussa HY, Shin KC, Ponraj J, Kim SJ, Ryu JK, Mansour S, Park Y#. Requirement of cholesterol for calcium-dependent vesicle fusion by strengthening synaptotagmin-1-induced membrane bending. Adv Sci. 2023 May;10(15):e2206823. Highlighted as a Frontispiece.

  • Ali Moussa HY, Park Y#. Electrostatic regulation of the cis- and trans-membrane interactions of synaptotagmin-1. Sci Rep. 2022 Dec 27;12(1):22407.

  • Park Y, Seo JB, Fraind A, Pérez-Lara A, Yavuz H, Han K, Jung SR, Kattan I, Walla PJ, Choi MY, Cafiso DS, Koh DS, Jahn R. Synaptotagmin-1 binds to PIP2-containing membrane but not to SNAREs at physiological ionic strength. Nature Struct Mol Biol. 2015 Oct;22(10):815-823.

  • Park Y, Hernandez J. M, van den Bogaart G, Ahmed S, Holt M, Riedel D, and Jahn R. Controlling synaptotagmin activity by electrostatic screening. Nature Struct Mol Biol. 2012 Oct;19(10):991-997.

  • Complete Publication Listing(s): NCBI
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