Dr. Mahbuba Rahman | Hamad Bin Khalifa University
Hamad Bin Khalifa University


Dr. Mahbuba Rahman

Dr. Mahbuba Rahman (PhD)

Postdoctoral Researcher
Translational Cancer and Immunity Center
Qatar Biomedical Research Institute QBRI

  • Phone+974 44548025
  • Office locationD156, RC-B2-1319


Dr. Mahbuba Rahman earned her BSc (Honors) and MSc in Microbiology from the University of Dhaka, Bangladesh, and her PhD in Metabolic Engineering from the Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Japan. After her PhD, she worked in several North American institutes including Children’s Hospital Research Institute (CHORI), Oakland, California; Texas A&M Health Sciences Center, College of Pharmacy, USA; at the Department of Medicine-University of British Columbia, BC Cancer Agency and Genome Science Center, Vancouver Canada. At BC Cancer Agency, she was involved with multiple translational projects including the identification of biomarkers for colon cancer, which generated several peer-reviewed publications.

Dr. Rahman joined Sidra Medicine in the Department of Systems Biology and Immunology in 2015. At Sidra, she established the PhIP-seq (phage-immunoprecipitation-sequencing) platform in collaboration with Harvard Medical University. The state-of-the-art platform has been used in a coronavirus seroprevalence study in Qatari adult, children, and immigrant populations. The platform was also used to study the association of viral infection and obesity in Qatar and for the assessment of immune responses to virus infection in primary immunodeficient patients.

Dr. Rahman has contributed to several research articles in high-impact journals including the New England Journal of Medicine, the Journal of Clinical Investigation, Journal of Clinical Insight, Nature Medicine and Cell. She is a reviewer of several journals including Nature Scientific Reports, BMC Microbiology, British Journal of Medicine and Medical Research, and British Journal of Pharmaceutical Research and book reviewer of Elsevier. She has also authored multiple review articles and book chapters over the last 10 years. She is an editor of an eBook on cancer immunotherapy and a special topic editor for Frontiers in Genetics.


Research Interests

  • Personalized Medicine
  • Cancer and Cell Biology
  • Metabolomics
  • Immunology
  • Virology


Staff Scientist-Associate Level

Department of Systems Biology and Immunology, Research Branch, Sidra Medicine, Doha, Qatar

2015 - 2020
  • Postdoctoral Fellow

    Department of Medicine, the University of British Columbia at Genome Sciences Center, BC Cancer Research Centre, Vancouver, BC, Canada

    2010 - 2013
  • Postdoctoral Fellow

    Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada

  • Postdoctoral Research Associate

    Department of Pharmacy, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, Texas, USA

    2008 - 2009
  • Researcher

    Gene Therapy, Children’s Hospital Oakland Research Institute (CHORI), Oakland, California, USA

  • Research Assistant

    Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Iizuka, Japan

    2006 - 2007
  • Research Officer

    STD Lab, Laboratory Sciences Division (LSD), International Center for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh

    1999 - 2000
  • Quality Control officer (Microbiology)

    Quality Control officer (Microbiology)

    1998 - 1999


PhD (Metabolic Engineering)

Kyushu Institute of Technology, Japan

  • Ms.Env (Environmental Management)

    Griffith University, Brisbane, Australia

  • MSc (Microbiology)

    University of Dhaka, Bangladesh

  • BSc (Honors, Microbiology)

    University of Dhaka, Bangladesh


Selected Publications

  • Beziat, V., Rapaport, F., Rahman, M., et al.

    Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy. Cell doi: 10.1016/j.cell.2021.06.004

  • Ogishi, M., Yang, R., Aytekin, C., Langlais, D., Bourgey, M., Khan, T., Al-Ali, F., Rahman, M., et al.

    Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child. Nature Medicine doi: 10.1038/s41591-021-01388-5

  • Hasan, MR., Rahman, M., et al.

    Virome-wide serological profiling reveals association of herpesviruses with obesity. Scientific Reports doi: 10.1038/s41598-021-82213-4

  • Khan, T., Rahman, M., et al.

    Distinct antibody repertoires against endemic human coronaviruses in children and adults. Journal of Clinical Investigation Insight doi: 10.1172/jci.insight.144499

  • Yu, A., Rahman, M., et al.

    Inhibition of nucleophosmin 1 suppresses colorectal cancer tumor growth of patient-derived xenografts via activation of p53 and inhibition of AKT. Cancer Biology & Therapy doi: 10.1080/15384047.2020.1839278

  • Drutman, SB., Mansouri, D., Mahdaviani, SA., Neehus, AL., Hum, D., Bryk, R., Hernandez, N., Belkaya, S., Rapaport, F., Bigio, B., Fisch, R., Rahman, M., et al.

    Fatal Cytomegalovirus Infection in an Adult with Inherited NOS2 Deficiency. New England Journal of Medicine doi: 10.1056/NEJMoa1910640

  • Yang, R., Rahman, M., et al.

    Human T-bet governs innate and innate-like adaptive IFN-γ immunity against mycobacteria. Cell doi :10.1016/j.cell.2020.10.046

  • Kerner, G., Rahman, M., et al.

    Inherited human IFN-γ deficiency underlies mycobacterial disease. Journal of Clinical Investigations doi: 10.1172/JCI135460

  • Rahman, M., and Hasan, MR

    “Synthetic Biopolymers”. Book entitled Functional Biopolymers. Polymers and Polymeric Composites: A Reference Series, Editors, Jafar Mazumder M., Sheardown H., Al-Ahmed A. Springer, Nature. doi: 10.1007/978-3-319-95990-0_1

  • Weiswald, LB., Hasan, MR., Wong, JC., Pasiliao, CC., Rahman, M., Ren, J., Yin et al.,

    Inactivation of the Kinase Domain of CDK10 Prevents Tumor Growth in a Preclinical Model of Colorectal Cancer, and Is Accompanied by Downregulation of Bcl-2. Molecular Cancer Therapeutics doi: 10.1158/1535-7163.MCT-16-0666

  • Rahman, M

    “Metabolic pathways and chemotherapy drugs”. Book entitled Frontiers in Drug Design and Discovery, Editors, Atta-ur-Rahman Bentham Science Publishers doi: 10.2174/9781681081656116070003

  • Rahman, M., and Hasan, MR.

    Cancer Metabolism and Drug Resistance. Metabolites doi.org/10.3390/metabo5040571

  • Rahman, M., and Hasan, MR.

    “Pentose Phosphate Pathway in Disease and Therapy”, in Advanced Materials Research, Editors M. A. Jafar Mazumder and Amir Al-Ahmed. Trans Tech Publications Inc.

  • Wong, JC., Hasan, MR., Rahman, M., Yu, AC., Chan, SK., Schaeffer, DF., Kennecke, HF., Lim, HJ., Owen, D., Tai, IT.

    Nucleophosmin 1, upregulated in adenomas and cancers of the colon, inhibits p53-mediated cellular senescence. International Journal of Cancer

  • Rahman, M., Selvarajan, K., Hasan, MR., et al.

    Inhibition of COX-2 in Colon Cancer Modulates Tumor Growth and MDR-1 Expression to Enhance Tumor Regression in Therapy-Refractory Cancers In Vivo. Neoplasia doi: 10.1593/neo.12486

  • Rahman, M., Chan, APK., Tang, M and Tai, IT.

    A peptide of SPARC interferes with the interaction between caspase8 and Bcl2 to resensitize chemoresistant tumors and enhance their regression in vivo. PLoS One doi: 10.1371/journal.pone.0026390