Dr. Khalid Ouararhni received his MSc. degree in molecular and cellular biology from Universite Pierre et Marie Curie, Paris in 2002and his PhD from Faculty of Medicine of Universite Paris XI, in 2007. His dissertation was on the role of epigenetics in cancer. He then completed a post-doctoral training at Institute de Genetique et BIologie Moleculaire et Cellulaire (IGBMC) in Strasbourg, under the supervision of Dr. Regine Losson. His research focus was to elucidate the role of nuclear receptor in oncogenesis. One of his seminal work during his post-doctoral training was the discovery of the interconnection between TRIM proteins and retinoic acid receptors and the relevance of such interconnection on suppressing murine hepatocellular carcinoma.
In 2011, Dr. Ouararhni joined the epigenetic research group at IGBMC under the supervision of Dr. Ali Hamiche where he started leading an important project on the role of histone variant in gene regulation and genome integrity. He made several major breakthroughs on the field of epigenetics. His contribution was highly cited by the scientific community as it helped in understanding the molecular mechanisms underlying histone variants deposition. He worked extensively on the isolation and purification of histone variant complexes and has studied their role using state of the art molecular and cell biology techniques.
Dr. Ouararhni moved to the Qatar Biomedical Research Institute in Doha as the Manager of the Cancer Research Center of QBRI. His work has been published in 5 stars scientific journals including Nature, Nature Structural Mol. Biol., Gene s & Development, and PNAS.