Qatar Biomedical Research Institute QBRI

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Modeling Autism and Diabetes through Stem-cell and Genomics Approach

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The Stanton lab is generating induced pluripotent stem cells (iPSC) from patients with neurodevelopmental disorders. These patient-specific iPSC are converted into neurons and organoids, thus providing an opportunity to understand the molecular pathology of diseases such as autism and establishing a foundation for the development of diagnostics and therapeutics.

Research Team

Current Projects

Latest Publications

  • A genomic biomarker that identifies human bone marrow-derived mesenchymal stem cells with high scalability. Sathiyanathan P, Samsonraj RM, Tan CCL, Ling L, Lezhava A, Nurcomb V, Lawrence W Stanton* , and Cool SM*(Co-senior authors) Stem Cells (epub 2020, June 8)
  • A balanced translocation in Kallmann Syndrome implicates a long non-coding RNA, RMST, as a GnRH neuronal regulator. Stamou M, Ng SY, Brand H, Wang H, Plummer L, Best L, Havlicek S, Hibberd M, Khor CC, Gusella J, Balasubramanian R, Talkowski M, Lawrence W Stanton* and Crowley WF* (Co-senior authors) J. Clinical Endocrinology and Metabolism 105(3), p231-244 (2020)
  • Phenotypic and molecular features underlying neurodegeneration of motor neurons derived from spinal bulbar muscular atrophy patients. Sheila M, Narayanan, G, Ma S, Tam WL, Chai J and Lawrence W Stanton Neurobiology of Disease 124, p1-13 (2019)
  • Single-cell gene expression analysis reveals regulators of distinct cell subpopulations among developing human neurons. Wang J, Jenjaroenpun P, Bhinge A, Angarica VE, Del Sol A, Nookaew I, Kuznetsov VA, and Lawrence W Stanton Genome Research 27(11), p1783-1794 (2017)
  • Genetic Correction of SOD1 and FUS mutations reveals MAPK activated AP1 and WNT as drivers of neurodegeneration in Amyotrophic Lateral Sclerosis. Bhinge A, Namboori S, and Lawrence W. Stanton Stem Cell Reports 8(4), p856-69 (2017)
  • Common molecular features underlying neurodegeneration identified through in vitro modeling of genetically diverse Parkinson’s disease patients. Lin L, Goke, J, Cukuroglu E, Dranias MR, Van Dongen AMJ, and Lawrence W. Stanton Cell Reports 15(11), p2411-26 (2016)
  • MiR-375 is essential for human spinal motor neuron development and may be involved in motor neuron degeneration. Bhinge A, Namboori S Angela Bithell, Soldati AC, Buckley NJ, Lawrence W. Stanton Stem Cells 34(1), p124-34 (2016)
  • miR-135b is a direct Pax6 target and specifies human neuroectoderm by inhibiting TGF-β/BMP signaling. Bhinge A, Poschman J, Tian XF, Loh JH, Traczyk A, Prabhakar S, and Lawrence W. Stanton EMBO J 33(11), p1271-83 (2014)
  • The long non-coding RNA RMST interferes with Sox2 to regulate neurogenesis. Ng SY, Bogu G, Soh BS, and Lawrence W. Stanton Molecular Cell 51(3), p349-59 (2013)
PubMed
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