Core Facilities

Located in Hamad Bin Khalifa University’s (HBKU) Research and Development Complex (RDC), QBRI’s state-of-the-art laboratories are major hubs in driving forward cutting edge research and innovation in Qatar and the region. The institute’s core facilities are located in the same building as QBRI’s research teams.

Advanced Imaging and Histopathology Core

The Advanced Imaging and Histopathology (AIH) Core is equipped with advanced and automated digital microscopy and live cell imaging instrumentation, allowing investigators to perform a variety of imaging experiments. The AIH core acts as a partner and consultant, playing a crucial role in developing the imaging experiment workflow, including experimental design, sample preparation, image data acquisition, image analysis, and presentation. QBRI’s core facility alone has more than 24 microscopes, 18 imaging systems and two plate readers.

The mission of the Advanced Imaging and Histopathology Core is to offer researchers efficient, reliable and innovative imaging solutions with the highest standards of instrumentation, accuracy, quality control and professional expertise. This is achieved by providing access to state-of the-art instrumentation and the expertise of highly skilled professionals in the fields of microscopy and imaging.

The unit is equipped with the most advanced and automated digital microscopy and live-cell imaging instrumentation. These technologies allow investigators to perform a wide variety of imaging research experiments that help them answer important biomedical questions related to their fields of study. The core also provides training and services that range from routine microscopy to cutting-edge live-animal multi-photon microscopy.

The core facility also provides cutting-edge histopathology equipment and services. Available equipment includes several up-to-date microtomes, cryostats, slide scanners and automated tissue processing, and staining systems.

The core’s expertise and services cover advice and support in the planning and evaluation of histopathology experiments, tissue processing and sectioning, cryopreservation, histological staining methods and laser capture microdissection microscopy.

Resources and Services

Optical Microscopy and Digital Imaging Equipment

  • Nikon A1+ MultiPhoton microscope
  • Zeiss LSM 780 confocal microscope inclusive of incubation chamber
  • Leica GSD super resolution microscope 🢦 Zeiss Primo Star upright microscope
  • Zeiss Axio Imager Z2 upright + camera fully automated fluorescence microscope
  • Olympus Inverted microscope IX73 and IX83 🢦 Zeiss Axio lmager A2 Microscope
  • Several Olympus microscopes and Phase Contrast microscopes (Upright and Inverted)

Services – Optical Microscopy and Digital Imaging

  • State-of-the-art microscopes for a wide variety of imaging research experiments
  • Cutting-edge bright-field, dark-field and fluorescence imaging
  • Standard, confocal and multi-photon microscopy applications
  • Automated digital microscopy
  • Advanced high-end live-cell imaging
  • Image processing and analysis tools
  • Training and education in microscopy and imaging 🢦 Enhanced level of imaging research (complemented by the centralized microscopy/ imaging central care facility)
  • Support with data analysis and presentation 🢦 Data management and storage

Histopathology Equipment

  • Digital whole slide scanner, Leica Aperio® AT2 Turbo 🢦 High quality digital slide scanner, Leica Aperio CS2
  • Automated upright microscope, Leica DM4000B
  • Semi-motorized rotary microtome, Leica RM2245
  • Cryostat, Leica Biosystems CM3050 S
  • Bright Instrument 8000 Sledge (Sliding Microtome)
  • Leica rotary microtome RM2125
  • Leica ASP6025 Automated Tissue Processor
  • Leica EG1150 modular tissue embedding center (incorporates two separate components, the Leica EGll50C cold plate and the Leica EG1150H heated embedding module)
  • Leica Biosystems ST5020 Multistainer
  • CryoViz robotic sectioning and imaging system 🢦 Dako Omnis automated staining System GI100 🢦 Dako Coverslipper

Services – Histopathology

  • Tissue processing, embedding and sectioning
  • Cryopreservation and cryosectioning (Leica Cryostat and Microtome systems)
  • Different histological staining methods, such as H&E and special stains
  • Immunohistochemical and immunofluorescence techniques
  • Laser Capture Microdissection microscopy (Leica)
  • Expert advice in the planning and evaluation of histopathology experiments

Major Instruments and Services

Major Instruments
  • Multiphoton
  • Confocal
  • Super Resolution
  • Wide Field
  • Fluorescence
  • Microscopes
Major Services
  • Image Acquisition
  • Histology
  • Experimental Design
  • Data Management
  • Training