أعضاء هيئة التدريس
الدكتور جورج نمر (PhD)
- البريد الإلكترونيgnemer@hbku.edu.qa
- الهاتف41 330
- موقع المكتبB-135, LAS
السيرة الذاتية
Dr. Georges M. Nemer is the Associate Dean Research at the College of Health and Life Sciences. He began his official role in January 2022 following the leave of the founding Dean, Dr. Edward Stuenkel. Professor Nemer has been leading the division of Genomics and Translational Biomedicine at the College since 2019.
Despite the COVID years, the success of the division was unprecedented in securing research funds, publishing high-impact factor journals, and graduating excellent students. Previously Dr. Nemer was the Director of Basic Science Affairs at the American University of Beirut where he mentored more than 40 graduate students, 20 postdocs in biochemistry and molecular genetics, and 16 classes of Med I students.
He has published over 120 papers in areas related to Congenital Heart Diseases and other inherited rare genetic disorders (Google Scholar: 130+ pubs, Total Citations ~ 5000, h-index 32, i10-index 68; ResearchGate: RG Score 40 (publication reads ~50,000) and book chapters. He served on the Editorial board of Scientific Reports and Frontiers in Cardiovascular Medicine and is a member of the community of experts at the European Science Foundation, the European Society of Cardiology, and the American and European Societies of Human Genetics.
الاهتمامات البحثية
Understanding the basis of congenital heart disease (CHD) requires a better understanding of key events during heart development. Given the fact that CHDs are still the leading cause of death in neonates, my primary research theme focuses on using basic genetics, and biochemical approaches to better understand these defects and ultimately try to offer better diagnosis, treatment, and follow up for these patients.
Having worked most of my research career on understanding the role of tissue-specific transcription factors in cell specification and organogenesis, my research interests widened to explore the role and expression of these genes in pathological conditions. This includes transcriptomic analysis and in vitro culture assays pertaining to genes like GATA, T-box, and Hand in numerous diseases that include amongst others cardiovascular and cancer.
Lastly, the analysis of multiple congenital diseases using exome sequencing technology has led me to have a more broadened approach to tackle the genetic basis of diseases such as Genodermatosis, hypercholesterolemia, hearing loss, vitamin D deficiency, etc..
الخبرات
Director of the Basic Science Research Faculty Affairs
American University of Beirut, Lebanon
2011 - 2019Professor
Department of Biochemistry and Molecular Genetics, American University of Beirut, Lebanon
2015 - 2019Associate Professor
Department of Biochemistry, American University of Beirut, Lebanon
2008 - 2015
Assistant Professor
Department of Biochemistry, American University of Beirut, Lebanon
2002 - 2008
المؤهلات العلمية
Ph.D. Pharmacology
Université de Montréal, Montreal, CANADA
1996 - 2002M.Sc. Pharmacology (direct passage to Ph.D.)
Université de Montréal, Montreal, CANADA
1994 - 1996B.Sc. Biology
American University of Beirut (AUB), Beirut, LEBANON
1989 - 1992
French Baccalaureate (mention)
Mont-La-Salle, Aïn Saadé, Lebanon
1989
المؤلفات المختارة
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Mishra PK, Nemer G. The non-coding genome and cardiovascular disease.
Front Cardiovasc Med. 2019 Jul 16;6:98. doi: 10.3389/fcvm.2019.00098. eCollection
2019 -
Genno P, Nemer G*, Bou Zeinedddine S, Macari A, and Ghafari J
Three novel genes tied to mandibular prognathism in East-Mediterranean families Am J Orthod Dentofacial Orthop. 2019 Jul;156(1):104-112.e3. doi: 10.1016/j.ajodo.2018.08.020.
2019 -
Nehme E, Rahal Z, Sinjab A, Khalil A, Chami H, Nemer G, Kadara H. Epigenetic suppression of the T-box Subfamily 2 (TBX2) in human non-small cell lung cancer.
Int J Mol Sci. 2019 Mar 7;20(5). pii: E1159. doi: 10.3390/ijms20051159.
2019 -
Hariri H, Kurban M, Al-Haddad C, Fahed A, Poladian S, Khalil A, Abbas O, Arabi M, Bitar F, Nemer G*. Degenerated Hair Follicle Cells and Partial Loss of Sebaceous and Eccrine Glands in a Familial Case of Axenfeld-Rieger Syndrome
An Emerging Role for the FOXC1/NFATC1 Genetic Axis. J Dermatol Sci. 2018 Dec;92(3):237-244. doi: 10.1016/j.jdermsci.2018.11.003
2018 -
Khalil A, Dekmak B, Boulos F, Kantrowitz J, Spira A, Fujimoto J, Kadara H, El-Hachem N, Nemer G*.
Transcriptomic alterations in lung adenocarcinoma unveil new mechanisms targeted by the TBX2 subfamily of tumor suppressor genes Front Oncol. 2018 Oct 30;8:482. doi: 10.3389/fonc.2018.00482.
2018 -
Abou Hassan OK, Haidar W, Nemer G*, Skouri H, Haddad F, BouAkl I. Clinical and genetic characteristics of pulmonary arterial hypertension in Lebanon.
BMC Med Genet. 2018 May 30;19(1):89. doi: 10.1186/s12881-018-0608-7.
2018 -
Khalil A, Al-Haddad C, Hariri H, Shibbani K, Bitar F, Kurban M, Nemer G*, Arabi M. A Novel Mutation in FOXC1 in a Lebanese Family with Congenital Heart Disease and Anterior Segment Dysgenesis
Potential Roles for NFATC1 and DPT in the Phenotypic Variations. Front Cardiovasc Med. 2017 Sep 20;4:58. doi:10.3389/fcvm.2017.00058.
2017 -
Khalil AA, Sivakumar S, Lucas FAS, McDowell T, Lang W, Tabata K, Fujimoto J, Yatabe Y, Spira A, Scheet P, Nemer G*, Kadara H. TBX2 subfamily suppression in lung cancer pathogenesis
A high-potential marker for early detection. Oncotarget. 2017 Aug 4;8(40):68230-68241. doi: 10.18632/oncotarget.19938.
2017 -
Khalil A, Tanos R, El-Hachem N, Kurban M, Bouvagnet P, Bitar F, Nemer G.
A Hand to TBX5 explains the link between Thalidomide and cardiac diseases. Sci Rep. 2017 May 3;7(1):1416. doi: 10.1038/s41598-017-01641-3.
2017 -
Bardawil T, Rebeiz A, Chaabouni M, El Halabi J, Kambris Z, Abbas O, Abou Hassan O, Hamie L, Bitar F, Kibbi AG, Nemer G.
and Kurban M. Mutations in the ABCG8 Gene are Associated with Sitosterolemia in the Homozygous Form and Xanthelasmas in the Heterozygous Form. Eur J Dermatol. 2017 Jul 25. doi: 10.1684/ejd.2017.3087.
2017 -
Shigehara Y, Okuda S, Nemer G, Chedraoui A, Hayashi R, Bitar F, Nakai H, Abbas O, Daou L, Abe R, Bou Sleiman R, Kibbi A, Kurban M, Shimomura Y.
Mutations in SDR9C7 gene encoding an enzyme for vitamin A metabolism underlie autosomal recessive congenital ichthyosis Hum Mol Genet. Aug 18. pii: ddw277.
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Fahed AC, Khalaf R, Salloum R, Andary RR, Safa R, El-Rassy I, Moubarak E, Azar ST, Bitar FF,Nemer G.
Variable expressivity and co-occurrence of LDLR and LDLRAP1 mutations in familial hypercholesterolemia: failure of the dominant and recessive dichotomy. Mol Genet Genomic Med. 24;4(3):283-91. doi: 10.1002/mgg3.203
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Kassab K, Hariri H, Gharibeh L, Fahed AC, Zein M, El-Rassy I, Nemer M, El-Rassi I, Bitar F, Nemer G.
GATA5 mutation homozygosity linked to a double outlet right ventricle phenotype in a Lebanese patient. Mol Genet Genomic Med. 20;4(2):160-71. doi: 10.1002/mgg3.190
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Refaat MM, Fahed AC, Hassanieh S, Hotait M, Arabi M, Skouri H, Seidman JG, Seidman CE, Bitar FF,Nemer G.
The Muscle-Bound Heart. Card Electrophysiol Clin. 8(1):223-31. doi: 10.1016/j.ccep.2015.10.034
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Abou-Hassan O, Fahed AC, Batrawi M, Arabi M, Refaat M, DePalm S, Seidman J, Seidman C, Bitar F, Nemer G.
Nkx2-5 Mutations in an Inbred Consanguineous Population: Genetic and Phenotypic Diversity. Sci Rep. Mar 6;5:8848. doi: 10.1038/srep08848, 2015
2015 -
Yang YQ, Gharibeh L, Li RG, Xin YF, Wang J, Liu ZM, Qiu XB, Xu YJ, Xu L, Qu XK, Liu X, Fang WY, Huang RT, Xue S, Nemer G.
GATA4 Loss-of-Function Mutations Underlie Familial Tetralogy of FALLOT. Hum Mutat. Sep 2. doi: 10.1002/humu.22434. [Epub ahead of print], 2013
2013 -
Azzam R, Hariri F, El-Hachem N, Kamar A, Dbaibo G, Nemer G,* Bitar F. Regulation of De Novo Ceramide Synthesis
The Role of Dihydroceramide Desaturase and Transcriptional Factors NFATC and Hand2 in the Hypoxic Mouse Heart. DNA Cell Biol. 2013 Jun;32(6):310-9
2013 -
AbdulSater Z, Yehya A,Beresian J, Salem E, Kamar A, Baydoun S, Shibbani K, Soubra A, Bitar F, and Nemer G.
Two heterozygous mutations in NFATC1 in a patient with tricuspid atresia. PLoS One. 7(11):e49532. doi: 10.1371/journal.pone.0049532. (2012)
2012 -
arhat T, Abdul-Sater Z, Obeid M, Arabi M, Diab K, Masri S, Al Haless Z, Nemer G.
Bitar F. Research in Congenital Heart Disease: A Comparative Bibliometric Analysis Between Developing and Developed Countries. Pediatr Cardiol. 34(2):375-82. (2012)
2012 -
Fahed A, Bitar F., Moubarak E., Azar S., Nemer G.
The Lebanese Allele at the LDLR in Normocholesterolemic People Merits Reconsideration of Genotype Phenotype Correlations in Familial Hypercholesterolemia. Endocrine. 42(2):445-8. (2012)
2012 -
Fahed A, Sleiman A, Farhat T, Nemer G.* Diet, DNA, and Disease
A Focus on the Eastern Mediterranean Region. Journal of Nutrition and Metabolism Volume 2012, Article ID 109037, 19 pages) (2012)
2012 -
El-Hachem N., Nemer G. *Identification of New GATA4-Small Molecule Inhibitors by Structure-Based Virtual Screening.
Bioorganic and Medicinal Chemistry 19(5):1734-42 (2011)
2011 -
Fahed AC, Safa RM, Haddad FF, Bitar FF, Andary RR, Arabi MT, Azar ST, Nemer G.
Homozygous familial hypercholesterolemia in Lebanon: A genotype/phenotype correlation. Mol Genet Metab. 102(2):181-8 (2011)
2011 -
Georges R , Nemer G.,* Lefebvre C, Nemer M.
Distinct Expression and Function of Alternatevily Spliced Tbx5 Isoforms in Cell Growth and Differentiation. Mol Cell Biol. 28(12):4052-67 (2008)
2008 -
Nemer G,* Fadlalah F, Usta J, Nemer M,Dbaibo G, Obeid M, and Bitar F.
A novel mutation in the GATA4 gene in patients with Tetralogy of Fallot. Human Mutation 27(3):293-4 (2006)
2006 -
Nemer G* and Nemer M
Cooperative interaction between GATA-5 and NF-ATc regulates endothelial-endocardial differentiation of cardiogenic cells. Development 129, 4045-4055 (2002)
2002 -
Bruneau BG, Nemer G*, Schmitt JP, Charron F, Robitaille L, Conner DA, Gessler M, Nemer M, Seidman CE, Seidman JG
A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and Disease. Cell 106(6), pp 709-721 (2001)
2001
تسجيل دخول بنر